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An overarching goal of personalized medicine is to identify individuals as risk for disease and tailor interventions based on genetic profiles of patients with diseases including cancer. BCS were recruited from Moffitt Cancer Center and University of South Florida\u2019s Breast Health Program and were randomized to either the 6-week MBSR(BC) program (n = 92) or Usual Care (n = 93). Measures of symptoms, demographic, and clinical history data were attained at baseline, 6 weeks, and 12 weeks. A total of 10 SNPs from eight genes known to be related to these symptoms were studied using genomic DNA extracted from blood. Our results were examined for effect sizes, consistency, and statistical significance (p &amp;lt; .05). Three SNPs (rs4680 in COMT, rs6314 in HTR2A, and rs429358 in APOE) emerged as having the strongest (though relatively weak) and most consistent effects in moderating the impact of the MBSR program on symptom outcomes. Although effects were generally weak, with only one effect withstanding multiple comparisons correction for statistical significance, this translational behavioral research may help start the identification of genetic profiles that moderate the impact of MBSR(BC). The ultimate goal of this study is the development of personalized treatment programs tailored to the genetic profile of each patient.<\/jats:p>","DOI":"10.1093\/tbm\/iby061","type":"journal-article","created":{"date-parts":[[2018,8,20]],"date-time":"2018-08-20T16:38:08Z","timestamp":1534783088000},"page":"693-702","source":"Crossref","is-referenced-by-count":13,"title":["Translational genomic research: the role of genetic polymorphisms in MBSR program among breast cancer survivors (MBSR[BC])"],"prefix":"10.1093","volume":"9","author":[{"given":"Jong Y","family":"Park","sequence":"first","affiliation":[{"name":"Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2700-2367","authenticated-orcid":false,"given":"Cecile A","family":"Lengacher","sequence":"first","affiliation":[{"name":"University of South Florida College of Nursing, Tampa, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard R","family":"Reich","sequence":"first","affiliation":[{"name":"Department of Cancer Epidemiology, H. 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