{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T11:40:22Z","timestamp":1783338022147,"version":"3.54.6"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2018,12,3]],"date-time":"2018-12-03T00:00:00Z","timestamp":1543795200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["K12HS022989"],"award-info":[{"award-number":["K12HS022989"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000133","name":"Agency for Healthcare Research and Quality","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000133","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["T32-MH18921"],"award-info":[{"award-number":["T32-MH18921"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,2,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Sickle cell disease (SCD) is a severe hemoglobinopathy characterized by acute and chronic pain. Sufferers of the disease, most of whom are underrepresented minorities, are at increased risk for mental health disorders. The purpose of this study is to test the acceptability and implementation of a computerized cognitive behavioral therapy (cCBT) intervention, Beating the Blues, to improve depression, anxiety, and pain in patients with SCD. Adults with SCD and significant symptoms of depression (Patient Health Questionnaire [PHQ-9] score \u2265 10) or anxiety (Generalized Anxiety Disorder Scale [GAD-7] score \u2265 10) were eligible to participate and be randomized to either receive eight sessions of cCBT with care coach support or treatment as usual. Participants reported daily pain and mood symptoms using a mobile diary app. Depression, anxiety, and pain symptoms were assessed at 1, 3, and 6 months. Thirty patients were enrolled: 18 to cCBT, and 12 to control. The cCBT intervention was feasible to implement in clinical settings and acceptable to participants. Patients in the cCBT arm reported a marginally greater decrease in depression at 6 months (\u22123.82, SE = 1.30) than those in the control group (\u22120.50, SE = 1.60; p = .06). There were no significant effects of treatment on anxiety; however, cCBT was associated with improved daily pain reported via a mobile diary app (p = .014). cCBT, delivered via mobile device, is a feasible strategy to provide mental health care to adults living with SCD. cCBT was acceptable to the target population; was able to be implemented in real-world, nonideal conditions; and has the potential to improve patient-reported outcomes.<\/jats:p>","DOI":"10.1093\/tbm\/iby107","type":"journal-article","created":{"date-parts":[[2018,12,3]],"date-time":"2018-12-03T04:23:42Z","timestamp":1543811022000},"page":"58-67","source":"Crossref","is-referenced-by-count":24,"title":["Feasibility of implementing mobile technology-delivered mental health treatment in routine adult sickle cell disease care"],"prefix":"10.1093","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5662-5806","authenticated-orcid":false,"given":"Charles R","family":"Jonassaint","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaeryon","family":"Kang","sequence":"first","affiliation":[{"name":"Department of Biostatistics, University of Pittsburgh, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kemar V","family":"Prussien","sequence":"first","affiliation":[{"name":"Department of Psychology and Human Development, Vanderbilt University, Nashville, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet","family":"Yarboi","sequence":"first","affiliation":[{"name":"Department of Psychology and Human Development, Vanderbilt University, Nashville, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maureen S","family":"Sanger","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J Deanna","family":"Wilson","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"De Castro","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nirmish","family":"Shah","sequence":"first","affiliation":[{"name":"Department of Medicine, Duke University, Durham, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urmimala","family":"Sarkar","sequence":"first","affiliation":[{"name":"UCSF Center for Vulnerable Populations, Zuckerberg San Francisco General Hospital, University of California, San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,12,3]]},"reference":[{"key":"2020061521432492900_CIT0001","doi-asserted-by":"crossref","first-page":"S512","DOI":"10.1016\/j.amepre.2009.12.022","article-title":"Population estimates of sickle cell disease in the U.S","volume":"38","author":"Hassell","year":"2010","journal-title":"Am J Prev Med"},{"issue":"1","key":"2020061521432492900_CIT0002","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1002\/ajh.21570","article-title":"The number of people with sickle-cell disease in the United States: National and state estimates","volume":"85","author":"Brousseau","year":"2010","journal-title":"Am J Hematol"},{"issue":"4","key":"2020061521432492900_CIT0003","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1097\/NCM.0000000000000260","article-title":"Barriers to care for persons with sickle cell disease: The case manager\u2019s opportunity to improve patient outcomes","volume":"23","author":"Brennan-Cook","year":"2018","journal-title":"Prof Case Manag"},{"issue":"4","key":"2020061521432492900_CIT0004","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.ajem.2012.11.005","article-title":"The impact of race and disease on sickle cell patient wait times in the emergency department","volume":"31","author":"Haywood","year":"2013","journal-title":"Am J Emerg Med"},{"key":"2020061521432492900_CIT0005","first-page":"1739","article-title":"NIH and national foundation expenditures for sickle cell disease and cystic fibrosis are associated with PubMed publications and FDA approvals","volume":"122","author":"Strouse","year":"2013","journal-title":"Blood"},{"issue":"3","key":"2020061521432492900_CIT0006","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1207\/s15327558ijbm1203_6","article-title":"A brief review of the pathophysiology, associated pain, and psychosocial issues in sickle cell disease","volume":"12","author":"Edwards","year":"2005","journal-title":"Int J Behav Med"},{"issue":"23","key":"2020061521432492900_CIT0007","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1056\/NEJM199406093302303","article-title":"Mortality in sickle cell disease: Life expectancy and risk factors for early death","volume":"330","author":"Platt","year":"1994","journal-title":"N Engl J Med"},{"issue":"6","key":"2020061521432492900_CIT0008","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1111\/j.1365-2141.2005.05500.x","article-title":"Psychological complications in sickle cell disease","volume":"129","author":"Anie","year":"2005","journal-title":"Br J Haematol"},{"issue":"1","key":"2020061521432492900_CIT0009","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/bjh.14023","article-title":"A systematic review of the association between depression and health care utilization in children and adults with sickle cell disease","volume":"174","author":"Jonassaint","year":"2016","journal-title":"Br J Haematol"},{"issue":"2","key":"2020061521432492900_CIT0010","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1097\/PSY.0b013e31815ff5c5","article-title":"Depression and anxiety in adults with sickle cell disease: The PiSCES project","volume":"70","author":"Levenson","year":"2008","journal-title":"Psychosom Med"},{"issue":"2","key":"2020061521432492900_CIT0011","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1001\/archpsyc.59.2.115","article-title":"Revised prevalence estimates of mental disorders in the United States: Using a clinical significance criterion to reconcile 2 surveys\u2019 estimates","volume":"59","author":"Narrow","year":"2002","journal-title":"Arch Gen Psychiatry"},{"issue":"1","key":"2020061521432492900_CIT0012","doi-asserted-by":"crossref","first-page":"18","DOI":"10.2105\/AJPH.77.1.18","article-title":"Psychiatric diagnoses of medical service users: Evidence from the epidemiologic catchment area program","volume":"77","author":"Kessler","year":"1987","journal-title":"Am J Public Health"},{"issue":"23","key":"2020061521432492900_CIT0013","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1182\/bloodadvances.2017006940","article-title":"Depression, quality of life, and medical resource utilization in sickle cell disease","volume":"1","author":"Adam","year":"2017","journal-title":"Blood Adv"},{"issue":"4","key":"2020061521432492900_CIT0014","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1300\/J010v38n04_04","article-title":"Integrating the health and mental health needs of the chronically ill: A group for individuals with depression and sickle cell disease","volume":"38","author":"Comer","year":"2004","journal-title":"Soc Work Health Care"},{"issue":"7","key":"2020061521432492900_CIT0015","first-page":"533","article-title":"Depression in sickle cell disease","volume":"95","author":"Hasan","year":"2003","journal-title":"J Natl Med Assoc"},{"key":"2020061521432492900_CIT0016","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/1477-7525-3-50","article-title":"Health related quality of life in sickle cell patients: The PiSCES project","volume":"3","author":"McClish","year":"2005","journal-title":"Health Qual Life Outcomes"},{"issue":"5","key":"2020061521432492900_CIT0017","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1097\/TP.0000000000000901","article-title":"Depression and anxiety as risk factors for morbidity and mortality after organ transplantation: A systematic review and meta-analysis","volume":"100","author":"Dew","year":"2015","journal-title":"Transplantation"},{"issue":"11","key":"2020061521432492900_CIT0018","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1017\/S0033291709992285","article-title":"Depression and cancer mortality: A meta-analysis","volume":"40","author":"Pinquart","year":"2010","journal-title":"Psychol Med"},{"issue":"10","key":"2020061521432492900_CIT0019","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s11886-016-0771-4","article-title":"Psychosocial factors in diabetes and cardiovascular risk","volume":"18","author":"Hackett","year":"2016","journal-title":"Curr Cardiol Rep"},{"issue":"11","key":"2020061521432492900_CIT0020","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1016\/S0027-9684(15)30737-9","article-title":"Psychosocial treatments in pain management of sickle cell disease","volume":"102","author":"Edwards","year":"2010","journal-title":"J Natl Med Assoc"},{"issue":"1","key":"2020061521432492900_CIT0021","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.cpr.2005.07.003","article-title":"The empirical status of cognitive-behavioral therapy: A review of meta-analyses","volume":"26","author":"Butler","year":"2006","journal-title":"Clin Psychol Rev"},{"key":"2020061521432492900_CIT0022","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1471-244X-14-5","article-title":"Cognitive behavioural therapy for the treatment of depression in people with multiple sclerosis: A systematic review and meta-analysis","volume":"14","author":"Hind","year":"2014","journal-title":"BMC Psychiatry"},{"issue":"3","key":"2020061521432492900_CIT0023","doi-asserted-by":"crossref","first-page":"625","DOI":"10.2337\/dc13-0816","article-title":"A randomized controlled trial of cognitive behavioral therapy for adherence and depression (CBT-AD) in patients with uncontrolled type 2 diabetes","volume":"37","author":"Safren","year":"2014","journal-title":"Diabetes Care"},{"issue":"1","key":"2020061521432492900_CIT0024","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1037\/a0012715","article-title":"A randomized controlled trial of cognitive behavioral therapy for adherence and depression (CBT-AD) in HIV-infected individuals","volume":"28","author":"Safren","year":"2009","journal-title":"Health Psychol"},{"issue":"3","key":"2020061521432492900_CIT0025","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.biopsych.2005.05.001","article-title":"Mood disorders in the medically ill: Scientific review and recommendations","volume":"58","author":"Evans","year":"2005","journal-title":"Biol Psychiatry"},{"key":"2020061521432492900_CIT0026","first-page":"CD001916","article-title":"Psychological therapies for sickle cell disease and pain","volume":"2","author":"Anie","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"issue":"8","key":"2020061521432492900_CIT0027","doi-asserted-by":"crossref","first-page":"e266","DOI":"10.2196\/jmir.7573","article-title":"How do ehealth programs for adolescents with depression work? A realist review of persuasive system design components in internet-based psychological therapies","volume":"19","author":"Wozney","year":"2017","journal-title":"J Med Internet Res"},{"key":"2020061521432492900_CIT0028","volume-title":"Computerized Cognitive Behavioral Therapy for depression and Anxiety. Review of Technology Appraisal 51","author":"(NICE) NIfHaCE","year":"2006"},{"issue":"3","key":"2020061521432492900_CIT0029","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1002\/pnp.163","article-title":"Computerised cognitive behavioural therapy and its uses","volume":"14","author":"Kaltenthaler","year":"2010","journal-title":"Prog Neurol Psychiatry"},{"issue":"7","key":"2020061521432492900_CIT0030","doi-asserted-by":"crossref","first-page":"e695","DOI":"10.4088\/JCP.13r08894","article-title":"A meta-analysis of computerized cognitive-behavioral therapy for the treatment of DSM-5 anxiety disorders","volume":"75","author":"Adelman","year":"2014","journal-title":"J Clin Psychiatry"},{"issue":"10","key":"2020061521432492900_CIT0031","doi-asserted-by":"crossref","first-page":"e13196","DOI":"10.1371\/journal.pone.0013196","article-title":"Computer therapy for the anxiety and depressive disorders is effective, acceptable and practical health care: A meta-analysis","volume":"5","author":"Andrews","year":"2010","journal-title":"PLoS One"},{"issue":"1","key":"2020061521432492900_CIT0032","doi-asserted-by":"crossref","first-page":"e84323","DOI":"10.1371\/journal.pone.0084323","article-title":"Qualitative meta-synthesis of user experience of computerised therapy for depression and anxiety","volume":"9","author":"Knowles","year":"2014","journal-title":"PLoS One"},{"issue":"2","key":"2020061521432492900_CIT0033","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1097\/MPH.0000000000001018","article-title":"Feasibility and acceptability of internet-delivered cognitive behavioral therapy for chronic pain in adolescents with sickle cell disease and their parents","volume":"40","author":"Palermo","year":"2018","journal-title":"J Pediatr Hematol Oncol"},{"issue":"9","key":"2020061521432492900_CIT0034","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1046\/j.1525-1497.2001.016009606.x","article-title":"The PHQ-9: Validity of a brief depression severity measure","volume":"16","author":"Kroenke","year":"2001","journal-title":"J Gen Intern Med"},{"issue":"10","key":"2020061521432492900_CIT0035","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1001\/archinte.166.10.1092","article-title":"A brief measure for assessing generalized anxiety disorder: The GAD-7","volume":"166","author":"Spitzer","year":"2006","journal-title":"Arch Intern Med"},{"issue":"5","key":"2020061521432492900_CIT0036","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1097\/00002508-200409000-00005","article-title":"Validity of the brief pain inventory for use in documenting the outcomes of patients with noncancer pain","volume":"20","author":"Keller","year":"2004","journal-title":"Clin J Pain"},{"issue":"2","key":"2020061521432492900_CIT0037","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3109\/03630269.2014.880716","article-title":"Patients welcome the sickle cell disease mobile application to record symptoms via technology (SMART)","volume":"38","author":"Shah","year":"2014","journal-title":"Hemoglobin"},{"issue":"3","key":"2020061521432492900_CIT0038","doi-asserted-by":"crossref","first-page":"162","DOI":"10.3109\/03630269.2015.1025141","article-title":"Usability and feasibility of an mhealth intervention for monitoring and managing pain symptoms in sickle cell disease: The sickle cell disease mobile application to record symptoms via technology (SMART)","volume":"39","author":"Jonassaint","year":"2015","journal-title":"Hemoglobin"},{"issue":"7434","key":"2020061521432492900_CIT0039","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1136\/bmj.37945.566632.EE","article-title":"Delivering interventions for depression by using the internet: Randomised controlled trial","volume":"328","author":"Christensen","year":"2004","journal-title":"BMJ"},{"issue":"2","key":"2020061521432492900_CIT0040","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1017\/S0033291702007225","article-title":"Computerized, interactive, multimedia cognitive-behavioural program for anxiety and depression in general practice","volume":"33","author":"Proudfoot","year":"2003","journal-title":"Psychol Med"},{"issue":"2","key":"2020061521432492900_CIT0041","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1177\/1094428106291059","article-title":"Estimating effect sizes from pretest-posttest-control group designs","volume":"11","author":"Morris","year":"2008","journal-title":"Organ Res Methods"},{"key":"2020061521432492900_CIT0042","volume-title":"The Behaviour Change Wheel: A Guide to Designing Interventions","author":"Michie","year":"2014"},{"issue":"3","key":"2020061521432492900_CIT0043","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1348\/135910799168588","article-title":"Cognitive-behaviour therapy for the management of sickle cell disease pain: An evaluation of a community-based intervention","volume":"4","author":"Thomas","year":"1999","journal-title":"Br J Health Psychol"},{"issue":"1","key":"2020061521432492900_CIT0044","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1056\/NEJM199107043250103","article-title":"Pain in sickle cell disease: Rates and risk factors","volume":"325","author":"Platt","year":"1991","journal-title":"N Engl J Med"},{"issue":"7","key":"2020061521432492900_CIT0045","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1093\/jpepsy\/jsn122","article-title":"Attrition in randomized controlled trials for pediatric chronic conditions","volume":"34","author":"Karlson","year":"2009","journal-title":"J Pediatr Psychol"},{"issue":"4","key":"2020061521432492900_CIT0046","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1037\/h0091863","article-title":"The efficacy of a pilot family psychoeducational intervention for pediatric sickle cell disease (SCD)","volume":"18","author":"Kaslow","year":"2000","journal-title":"Fam Syst Health"},{"issue":"4","key":"2020061521432492900_CIT0047","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1017\/S135246580200406X","article-title":"Self-help manual-assisted cognitive behavioural therapy for sickle cell disease","volume":"30","author":"Anie","year":"2002","journal-title":"Behav Cogn Psychother"},{"key":"2020061521432492900_CIT0048","doi-asserted-by":"crossref","DOI":"10.1093\/med:psych\/9780199763979.001.0001","volume-title":"Cognitive-Behavioral Therapy for Chronic Pain in Children and Adolescents","author":"Palermo","year":"2012","edition":"1st ed"},{"issue":"5","key":"2020061521432492900_CIT0049","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1093\/jpepsy\/jsx141","article-title":"Cognitive function, coping, and depressive symptoms in children and adolescents with sickle cell disease","volume":"43","author":"Prussien","year":"2018","journal-title":"J Pediatr Psychol"}],"container-title":["Translational Behavioral Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/tbm\/article-pdf\/10\/1\/58\/33391518\/iby107.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/tbm\/article-pdf\/10\/1\/58\/33391518\/iby107.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,12]],"date-time":"2024-07-12T23:12:22Z","timestamp":1720825942000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/tbm\/article\/10\/1\/58\/5227420"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,3]]},"references-count":49,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2018,12,3]]},"published-print":{"date-parts":[[2020,2,3]]}},"URL":"https:\/\/doi.org\/10.1093\/tbm\/iby107","relation":{},"ISSN":["1869-6716","1613-9860"],"issn-type":[{"value":"1869-6716","type":"print"},{"value":"1613-9860","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,2]]},"published":{"date-parts":[[2018,12,3]]}}}