{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T05:52:05Z","timestamp":1775281925702,"version":"3.50.1"},"reference-count":55,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2020,9,16]],"date-time":"2020-09-16T00:00:00Z","timestamp":1600214400000},"content-version":"vor","delay-in-days":259,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Whitehall Foundation Research"},{"DOI":"10.13039\/100007289","name":"Purdue Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01 MH116500"],"award-info":[{"award-number":["R01 MH116500"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,8,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Serotonin (5-hydroxytryptamine) is crucial for the proper development of neuronal circuits early in life and their refinement throughout adulthood. Its signaling is tightly regulated by the serotonin transporter (SERT), alterations of which were implicated in various neurological and psychiatric disorders. Animal models lacking a functional SERT variant display diverse phenotypes, including increased anxiety, social communication deficits, and altered cortical development. However, it remains unclear how SERT disruption affects sensory processing and experience-dependent learning in adulthood. It has been previously shown that perceptual experience leads to the development of visual familiarity-evoked theta oscillations in mouse V1. Here, we discovered that familiarity-evoked theta oscillations were longer and less stimulus specific in SERT knockout (KO) compared with wild-type (WT) mice. Interestingly, while the overall visual response properties were similar in naive mice, orientation and spatial frequency processing were significantly impaired in SERT KO compared with WT or SERT heterozygous mice following perceptual experience. Our findings shed more light on the mechanism of familiarity-evoked oscillations and highlight the importance of serotonin signaling in perceptual learning.<\/jats:p>","DOI":"10.1093\/texcom\/tgaa066","type":"journal-article","created":{"date-parts":[[2020,9,16]],"date-time":"2020-09-16T13:35:38Z","timestamp":1600263338000},"source":"Crossref","is-referenced-by-count":2,"title":["Cortical Tuning is Impaired After Perceptual Experience in Primary Visual Cortex of Serotonin Transporter-Deficient Mice"],"prefix":"10.1093","volume":"1","author":[{"given":"Alexandr","family":"Pak","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, IN 47907, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8224-9296","authenticated-orcid":false,"given":"Alexander A","family":"Chubykin","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, IN 47907, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,9,16]]},"reference":[{"key":"2021051810485567300_ref1","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1152\/jn.1982.48.1.217","article-title":"Striate cortex of monkey and cat: contrast response function","volume":"48","author":"Albrecht","year":"1982","journal-title":"J Neurophysiol."},{"key":"2021051810485567300_ref2","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1126\/science.1101678","article-title":"Early-life blockade of the 5-HT transporter alters emotional behavior in adult mice","volume":"306","author":"Ansorge","year":"2004","journal-title":"Science."},{"key":"2021051810485567300_ref3","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1124\/mol.53.4.649","article-title":"Altered brain serotonin homeostasis and locomotor 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