{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T23:02:11Z","timestamp":1782428531857,"version":"3.54.5"},"reference-count":75,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2021,1,23]],"date-time":"2021-01-23T00:00:00Z","timestamp":1611360000000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institute of Health Research","doi-asserted-by":"crossref","award":["NSB 2019-2024"],"award-info":[{"award-number":["NSB 2019-2024"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000038","name":"Natural Science and Engineering Research Council of Canada","doi-asserted-by":"crossref","award":["RGPIN 2015"],"award-info":[{"award-number":["RGPIN 2015"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Epilepsy is a chronic neurological disorder characterized by spontaneous recurrent seizures (SRS) and comorbidities. Kindling through repetitive brief stimulation of a limbic structure is a commonly used model of temporal lobe epilepsy. Particularly, extended kindling over a period up to a few months can induce SRS, which may simulate slowly evolving epileptogenesis of temporal lobe epilepsy. Currently, electroencephalographic (EEG) features of SRS in rodent models of extended kindling remain to be detailed. We explored this using a mouse model of extended hippocampal kindling. Intracranial EEG recordings were made from the kindled hippocampus and unstimulated hippocampal, neocortical, piriform, entorhinal, or thalamic area in individual mice. Spontaneous EEG discharges with concurrent low-voltage fast onsets were observed from the two corresponding areas in nearly all SRS detected, irrespective of associated motor seizures. Examined in brain slices, epileptiform discharges were induced by alkaline artificial cerebrospinal fluid in the hippocampal CA3, piriform and entorhinal cortical areas of extended kindled mice but not control mice. Together, these in vivo and in vitro observations suggest that the epileptic activity involving a macroscopic network may generate concurrent discharges in forebrain areas and initiate SRS in hippocampally kindled mice.<\/jats:p>","DOI":"10.1093\/texcom\/tgab004","type":"journal-article","created":{"date-parts":[[2021,3,29]],"date-time":"2021-03-29T05:26:16Z","timestamp":1616995576000},"source":"Crossref","is-referenced-by-count":9,"title":["Electrographic Features of Spontaneous Recurrent Seizures in a Mouse Model of Extended Hippocampal Kindling"],"prefix":"10.1093","volume":"2","author":[{"given":"Haiyu","family":"Liu","sequence":"first","affiliation":[{"name":"Departments of Neurosurgery, The First Hospital of Jilin University, Changchun, Jilin 130021 China"},{"name":"Krembil Research Institute, University Health Network, Toronto, Ontario, Canada M5T 2S8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uilki","family":"Tufa","sequence":"additional","affiliation":[{"name":"Krembil Research Institute, University Health Network, Toronto, Ontario, Canada M5T 2S8"},{"name":"Department of Electrical and Computer Engineering, University of Toronto, Toronto, Ontario M5S 3H5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anya","family":"Zahra","sequence":"additional","affiliation":[{"name":"Krembil Research Institute, University Health Network, Toronto, Ontario, Canada M5T 2S8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Chow","sequence":"additional","affiliation":[{"name":"Krembil Research Institute, University Health Network, Toronto, Ontario, Canada M5T 2S8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nila","family":"Sivanenthiran","sequence":"additional","affiliation":[{"name":"Krembil Research Institute, University Health Network, Toronto, Ontario, Canada M5T 2S8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chloe","family":"Cheng","sequence":"additional","affiliation":[{"name":"Krembil Research Institute, University Health Network, Toronto, Ontario, Canada M5T 2S8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yapg","family":"Liu","sequence":"additional","affiliation":[{"name":"Krembil Research Institute, University Health Network, Toronto, Ontario, Canada M5T 2S8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phinehas","family":"Cheung","sequence":"additional","affiliation":[{"name":"Krembil Research Institute, University Health Network, Toronto, Ontario, Canada M5T 2S8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stellar","family":"Lim","sequence":"additional","affiliation":[{"name":"Krembil Research Institute, University Health Network, Toronto, Ontario, Canada M5T 2S8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaozhong","family":"Jin","sequence":"additional","affiliation":[{"name":"Krembil Research Institute, University Health Network, Toronto, Ontario, Canada M5T 2S8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Mao","sequence":"additional","affiliation":[{"name":"Krembil Research Institute, University Health Network, Toronto, Ontario, Canada M5T 2S8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqing","family":"Sun","sequence":"additional","affiliation":[{"name":"Krembil Research Institute, University Health Network, Toronto, Ontario, Canada M5T 2S8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiping","family":"Wu","sequence":"additional","affiliation":[{"name":"Krembil Research Institute, University Health Network, Toronto, Ontario, Canada M5T 2S8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Wennberg","sequence":"additional","affiliation":[{"name":"Krembil Research Institute, University Health Network, Toronto, Ontario, Canada M5T 2S8"},{"name":"Department of Medicine, University of Toronto, Toronto, Ontario M2K 1E2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berj","family":"Bardakjian","sequence":"additional","affiliation":[{"name":"Department of Electrical and Computer Engineering, University of Toronto, Toronto, Ontario M5S 3H5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter L","family":"Carlen","sequence":"additional","affiliation":[{"name":"Krembil Research Institute, University Health Network, Toronto, Ontario, Canada M5T 2S8"},{"name":"Department of Medicine, University of Toronto, Toronto, Ontario M2K 1E2, Canada"},{"name":"Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James H","family":"Eubanks","sequence":"additional","affiliation":[{"name":"Krembil Research Institute, University Health Network, Toronto, Ontario, Canada M5T 2S8"},{"name":"Department of Surgery, University of Toronto, Toronto, Ontario M5G 1X5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongmei","family":"Song","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery, The First Hospital of Jilin University, Changchun, Jilin 130021 China"},{"name":"Krembil Research Institute, University Health Network, Toronto, Ontario, Canada M5T 2S8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Krembil Research Institute, University Health Network, Toronto, Ontario, Canada M5T 2S8"},{"name":"Department of Medicine, University of Toronto, Toronto, Ontario M2K 1E2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,1,22]]},"reference":[{"key":"2021060422113004100_ref1","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/0306-4522(89)90424-7","article-title":"The three-dimensional organization of the hippocampal formation: a review of anatomical data","volume":"31","author":"Amaral","year":"1998","journal-title":"Neuroscience"},{"key":"2021060422113004100_ref2","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/B978-0-12-804066-9.00011-0","volume-title":"Models of seizures and epilepsy","author":"Aronica","year":"2017","edition":"2nd"},{"issue":"6","key":"2021060422113004100_ref3","doi-asserted-by":"crossref","first-page":"3229","DOI":"10.1152\/jn.01128.2015","article-title":"Specific imbalance of excitatory\/inhibitory signaling establishes seizure onset pattern in temporal lobe epilepsy","volume":"115","author":"Avoli","year":"2016","journal-title":"J Neurophysiol"},{"key":"2021060422113004100_ref4","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.3389\/fneur.2019.01132","article-title":"Assessing epileptogenicity using phase-locked high frequency oscillations: a systematic comparison of methods","volume":"10","author":"Bandarabadi","year":"2019","journal-title":"Front Neurol"},{"key":"2021060422113004100_ref5","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.yebeh.2014.07.012","article-title":"Extratemporal lobe circuits in temporal lobe epilepsy","volume":"38","author":"Bertram","year":"2014","journal-title":"Epilepsy Behav"},{"issue":"8","key":"2021060422113004100_ref6","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1046\/j.1528-1157.2001.042008967.x","article-title":"The midline thalamus: alterations and a potential role in limbic epilepsy","volume":"42","author":"Bertram","year":"2001","journal-title":"Epilepsia"},{"key":"2021060422113004100_ref7","doi-asserted-by":"crossref","first-page":"172","DOI":"10.3389\/fnbeh.2017.00172","article-title":"Continuous monitoring via tethered electroencephalography of spontaneous recurrent seizures in mice","volume":"11","author":"Bin","year":"2017","journal-title":"Front Behav Neurosci"},{"issue":"10","key":"2021060422113004100_ref8","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1111\/j.1528-1167.2005.00268.x","article-title":"Analysis of chronic seizure onsets after intrahippocampal kainic acid injection in freely moving rats","volume":"46","author":"Bragin","year":"2005","journal-title":"Epilepsia"},{"issue":"2\u20133","key":"2021060422113004100_ref9","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.eplepsyres.2004.08.008","article-title":"Epilepsy induced by extended amygdala-kindling in rats: lack of clear association between development of spontaneous seizures and neuronal damage","volume":"62","author":"Brandt","year":"2004","journal-title":"Epilepsy Res"},{"issue":"10","key":"2021060422113004100_ref10","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1002\/hipo.22488","article-title":"Hippocampal sharp wave-ripple: a cognitive biomarker for episodic memory and planning","volume":"25","author":"Buzs\u00e1ki","year":"2015","journal-title":"Hippocampus"},{"issue":"6","key":"2021060422113004100_ref11","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/nrn3241","article-title":"The origin of extracellular fields and currents\u2013EEG, ECoG, LFP and spikes","volume":"13","author":"Buzs\u00e1ki","year":"2012","journal-title":"Nat Rev Neurosci"},{"issue":"5","key":"2021060422113004100_ref12","doi-asserted-by":"crossref","first-page":"3106","DOI":"10.1523\/JNEUROSCI.14-05-03106.1994","article-title":"Neuronal loss induced in limbic pathways by kindling: evidence for induction of hippocampal sclerosis by repeated brief seizures","volume":"14","author":"Cavazos","year":"1994","journal-title":"J Neurosci"},{"issue":"3","key":"2021060422113004100_ref13","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1111\/epi.12918","article-title":"Mapping the coherence of ictal high frequency oscillations in human extratemporal lobe epilepsy","volume":"56","author":"Cotic","year":"2015","journal-title":"Epilepsia"},{"issue":"3","key":"2021060422113004100_ref14","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1111\/j.1528-1167.2009.02273.x","article-title":"Antiepileptic drugs abolish ictal but not interictal epileptiform discharges in vitro","volume":"51","author":"D'Antuono","year":"2010","journal-title":"Epilepsia"},{"key":"2021060422113004100_ref15","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.eplepsyres.2018.04.005","article-title":"Potassium dynamics and seizures: why is potassium ictogenic?","volume":"143","author":"Curtis","year":"2018","journal-title":"Epilepsy Res"},{"key":"2021060422113004100_ref16","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/B978-0-12-804066-9.00041-9","volume-title":"Models of seizures and epilepsy","author":"Dudek","year":"2017","edition":"2nd"},{"key":"2021060422113004100_ref17","doi-asserted-by":"crossref","first-page":"2863","DOI":"10.1093\/cercor\/bhr080","article-title":"Acute post-ischemic seizures are associated with increased mortality and brain damage in adult mice","volume":"21","author":"El-Hayek","year":"2011","journal-title":"Cereb Cortex"},{"key":"2021060422113004100_ref18","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0920-1211(96)00043-5","article-title":"Introduction to temporal lobe epilepsy","volume":"26","author":"Engel","year":"1996","journal-title":"Epilepsy Res"},{"key":"2021060422113004100_ref19","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.phrs.2016.02.013","article-title":"Challenges in the pharmacological management of epilepsy and its causes in the elderly","volume":"106","author":"Ferlazzo","year":"2016","journal-title":"Pharmacol Res"},{"key":"2021060422113004100_ref20","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/B978-012369454-6\/50074-1","volume-title":"The mouse in biomedical research","author":"Flurkey","year":"2007","edition":"2nd"},{"key":"2021060422113004100_ref21","volume-title":"The mouse brain in stereotaxic coordinates","author":"Franklin","year":"1997"},{"key":"2021060422113004100_ref22","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/B978-0-12-804066-9.00044-4","volume-title":"Models of seizures and epilepsy","author":"Gorter","year":"2017","edition":"2nd"},{"key":"2021060422113004100_ref23","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.jneumeth.2015.03.025","article-title":"Which insights have we gained from the kindling and post-status epilepticus models?","volume":"260","author":"Gorter","year":"2016","journal-title":"J Neurosci Methods"},{"issue":"2","key":"2021060422113004100_ref24","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/0014-4886(84)90223-1","article-title":"Relationships between triggered seizures, spontaneous seizures, and interictal spiking in the kindling model of epilepsy","volume":"84","author":"Gotman","year":"1984","journal-title":"Exp Neurol"},{"key":"2021060422113004100_ref25","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcaa182","article-title":"Delta-gamma phase-amplitude coupling as a biomarker of postictal generalized EEG suppression","author":"Grigorovsky","year":"2020","journal-title":"Brain Commun"},{"issue":"2","key":"2021060422113004100_ref26","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.jneumeth.2009.06.005","article-title":"Establishing a physiological environment for visualized in vitro brain slice recordings by increasing oxygen supply and modifying ACSF content","volume":"183","author":"H\u00e1jos","year":"2009","journal-title":"J Neurosci Methods"},{"key":"2021060422113004100_ref27","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/B978-0-12-804066-9.00042-0","volume-title":"Models of seizures and epilepsy","author":"Henshall","year":"2017","edition":"2nd"},{"issue":"3","key":"2021060422113004100_ref28","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1111\/j.1528-1157.1993.tb02580.x","article-title":"Evidence of secondary epileptogenesis in amygdaloid overkindled cats: electroclinical documentation of spontaneous seizures","volume":"34","author":"Hiyoshi","year":"1993","journal-title":"Epilepsia"},{"issue":"5","key":"2021060422113004100_ref29","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/nn.2790","article-title":"Glutamatergic pre-ictal discharges emerge at the transition to seizure in human epilepsy","volume":"14","author":"Huberfeld","year":"2011","journal-title":"Nat Neurosci"},{"issue":"11","key":"2021060422113004100_ref30","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.tins.2015.09.001","article-title":"Neural cross-frequency coupling: connecting architectures, mechanisms, and functions","volume":"38","author":"Hyafil","year":"2015","journal-title":"Trends Neurosci"},{"key":"2021060422113004100_ref31","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.neuroscience.2013.10.074","article-title":"Novel anticonvulsive effects of progesterone in a mouse model of hippocampal electrical kindling","volume":"257","author":"Jeffrey","year":"2014","journal-title":"Neuroscience"},{"issue":"Pt 2","key":"2021060422113004100_ref32","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1093\/brain\/awt348","article-title":"Physiological sharp wave-ripples and interictal events in vitro: what's the difference?","volume":"137","author":"Karl\u00f3cai","year":"2014","journal-title":"Brain"},{"key":"2021060422113004100_ref33","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/B978-0-12-804066-9.00043-2","volume-title":"Models of seizures and epilepsy","author":"Kelly","year":"2017","edition":"2nd"},{"issue":"38","key":"2021060422113004100_ref34","doi-asserted-by":"crossref","first-page":"13264","DOI":"10.1523\/JNEUROSCI.5086-11.2012","article-title":"Two seizure-onset types reveal specific patterns of high-frequency oscillations in a model of temporal lobe epilepsy","volume":"32","author":"L\u00e9vesque","year":"2012","journal-title":"J Neurosci"},{"issue":"1","key":"2021060422113004100_ref35","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1038\/s41598-018-19675-6","article-title":"Seizure development in the acute intrahippocampal epileptic focus","volume":"8","author":"Li","year":"2018","journal-title":"Sci Rep"},{"key":"2021060422113004100_ref36","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.3389\/fphar.2019.01077","article-title":"Impaired spatial learning and memory in middle-aged mice with kindling-induced spontaneous recurrent seizures","volume":"10","author":"Liu","year":"2019","journal-title":"Front Pharmacol"},{"key":"2021060422113004100_ref37","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.eplepsyres.2016.05.016","article-title":"Fit for purpose application of currently existing animal models in the discovery of novel epilepsy therapies","volume":"126","author":"L\u00f6scher","year":"2016","journal-title":"Epilepsy Res"},{"issue":"1\u20132","key":"2021060422113004100_ref39","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0006-8993(98)00606-4","article-title":"Self-sustaining status epilepticus after brief electrical stimulation of the perforant path","volume":"801","author":"Mazarati","year":"1998","journal-title":"Brain Res"},{"key":"2021060422113004100_ref40","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.neuroscience.2014.07.048","article-title":"Intracellular activities related to in vitro hippocampal sharp waves are altered in CA3 pyramidal neurons of aged mice","volume":"277","author":"Moradi-Chameh","year":"2014","journal-title":"Neuroscience"},{"issue":"1\u20132","key":"2021060422113004100_ref41","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0006-8993(98)00155-3","article-title":"Development of spontaneous seizures over extended electrical kindling. I. Electrographic, behavioral, and transfer kindling correlates","volume":"793","author":"Michael","year":"1998","journal-title":"Brain Res"},{"issue":"1","key":"2021060422113004100_ref42","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/0006-8993(94)01277-O","article-title":"Development of spontaneous seizures over extended electrical kindling. II. Persistence of dentate inhibitory suppression","volume":"670","author":"Milgram","year":"1995","journal-title":"Brain Res"},{"issue":"6","key":"2021060422113004100_ref43","doi-asserted-by":"crossref","first-page":"e5759","DOI":"10.1371\/journal.pone.0005759","article-title":"Does pilocarpine-induced epilepsy in adult rats require status epilepticus?","volume":"4","author":"Navarro Mora","year":"2009","journal-title":"PLoS One"},{"issue":"2","key":"2021060422113004100_ref45","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/0014-4886(78)90133-4","article-title":"Electrode placement and kindling-induced experimental epilepsy","volume":"58","author":"Pinel","year":"1978","journal-title":"Exp Neurol"},{"key":"2021060422113004100_ref46","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/0014-4886(78)90145-0","article-title":"Experimental epileptogenesis: kindling-induced epilepsy in rats","volume":"58","author":"Pinel","year":"1978","journal-title":"Exp Neurol"},{"key":"2021060422113004100_ref47","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/0013-4694(72)90177-0","article-title":"Modification of seizure activity by electrical stimulation. II. Motor seizure","volume":"32","author":"Racine","year":"1972","journal-title":"Electroencephalogr Clin Neurophysiol"},{"issue":"2\u20133","key":"2021060422113004100_ref48","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.eplepsyres.2010.01.009","article-title":"Ganaxolone suppression of behavioral and electrographic seizures in the mouse amygdala kindling model","volume":"89","author":"Reddy","year":"2010","journal-title":"Epilepsy Res"},{"issue":"2","key":"2021060422113004100_ref49","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1523\/JNEUROSCI.4488-10.2011","article-title":"Development and persistence of limbic epileptogenesis are impaired in mice lacking progesterone receptors","volume":"31","author":"Reddy","year":"2011","journal-title":"J Neurosci"},{"key":"2021060422113004100_ref50","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/978-94-007-7359-2_14","article-title":"Carbonic anhydrases and brain pH in the control of neuronal excitability","volume":"75","author":"Ruusuvuori","year":"2014","journal-title":"Subcell Biochem"},{"key":"2021060422113004100_ref51","doi-asserted-by":"publisher","first-page":"113373","DOI":"10.1016\/j.expneurol.2020.113373","article-title":"Increased epileptogenicity in a mouse model of neurofibromatosis type 1","volume":"331","author":"Sabetghadam","year":"2020","journal-title":"Exp Neurol"},{"issue":"7","key":"2021060422113004100_ref53","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.1523\/JNEUROSCI.23-07-02759.2003","article-title":"Spontaneous seizures and loss of axo-axonic and axo-somatic inhibition induced by repeated brief seizures in kindled rats","volume":"23","author":"Sayin","year":"2003","journal-title":"J Neurosci"},{"key":"2021060422113004100_ref54","doi-asserted-by":"crossref","first-page":"1759091419833502","DOI":"10.1177\/1759091419833502","article-title":"Astrocyte and neuronal Pannexin1 contribute distinctly to seizures","volume":"11","author":"Scemes","year":"2019","journal-title":"ASN Neuro"},{"key":"2021060422113004100_ref55","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1111\/j.1460-9568.2012.07993.x","article-title":"Hippocampal CA3 and CA2 have distinct bilateral innervation patterns to CA1 in rodents","volume":"35","author":"Shinohara","year":"2015","journal-title":"Eur J Neurosci"},{"key":"2021060422113004100_ref56","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0006-8993(90)90867-B","article-title":"The ontogeny of feline temporal lobe epilepsy: kindling a spontaneous seizure disorder in kittens","volume":"525","author":"Shouse","year":"1990","journal-title":"Brain Res"},{"key":"2021060422113004100_ref57","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1111\/j.1528-1157.1992.tb02183.x","article-title":"Ontogeny of feline temporal lobe epilepsy II: stability of spontaneous sleep epilepsy in amygdala-kindled kittens","volume":"33","author":"Shouse","year":"1992","journal-title":"Epilepsia"},{"issue":"2","key":"2021060422113004100_ref58","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.nbd.2011.04.017","article-title":"Excitatory amplification through divergent-convergent circuits: the role of the midline thalamus in limbic seizures","volume":"43","author":"Sloan","year":"2011","journal-title":"Neurobiol Dis"},{"key":"2021060422113004100_ref59","doi-asserted-by":"crossref","first-page":"278","DOI":"10.3389\/fncel.2018.00278","article-title":"Contributions of the hippocampal CA3 circuitry to acute seizures and hyperexcitability responses in mouse models of brain ischemia","volume":"12","author":"Song","year":"2018","journal-title":"Front Cell Neurosci"},{"key":"2021060422113004100_ref60","doi-asserted-by":"crossref","first-page":"451","DOI":"10.3389\/fphar.2018.00451","article-title":"Effects of antiepileptic drugs on spontaneous recurrent seizures in a novel model of extended hippocampal kindling in mice","volume":"9","author":"Song","year":"2018","journal-title":"Front Pharmacol"},{"key":"2021060422113004100_ref61","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.ibror.2017.08.001","article-title":"Susceptibility to hippocampal kindling seizures is increased in aging C57 black mice","volume":"3","author":"Stover","year":"2017","journal-title":"IBRO Rep"},{"key":"2021060422113004100_ref62","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/B978-0-12-804066-9.00055-9","volume-title":"Models of seizures and epilepsy","author":"Sutula","year":"2017","edition":"2nd"},{"issue":"6","key":"2021060422113004100_ref63","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1080\/87565641.2011.619241","article-title":"Coherence, phase differences, phase shift, and phase lock in EEG\/ERP analyses","volume":"37","author":"Thatcher","year":"2012","journal-title":"Dev Neuropsychol"},{"issue":"2","key":"2021060422113004100_ref64","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1152\/jn.00106.2010","article-title":"Measuring phase-amplitude coupling between neuronal oscillations of different frequencies","volume":"104","author":"Tort","year":"2010","journal-title":"J Neurophysiol"},{"issue":"1\u20132","key":"2021060422113004100_ref66","first-page":"49","article-title":"Functional and anatomic correlates of two frequently observed temporal lobe seizure-onset patterns","volume":"7","author":"Velasco","year":"2007","journal-title":"Neural Plast"},{"key":"2021060422113004100_ref67","doi-asserted-by":"crossref","first-page":"27","DOI":"10.3389\/fncir.2015.00027","article-title":"The piriform, perirhinal, and entorhinal cortex in seizure generation","volume":"9","author":"Vismer","year":"2015","journal-title":"Front Neural Circuits"},{"issue":"4","key":"2021060422113004100_ref68","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1017\/S031716710002062X","article-title":"Recurrent spontaneous seizure state induced by prefrontal kindling in Ssenegalese baboons, Papio papio","volume":"2","author":"Wada","year":"1975","journal-title":"Can J Neurol Sci"},{"key":"2021060422113004100_ref69","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1212\/WNL.26.3.273","article-title":"Spontaneous recurrent seizure state induced by daily electric amygdaloid stimulation in Senegalese baboons (Papiopapio)","volume":"26","author":"Wada","year":"1976","journal-title":"Neurologija"},{"key":"2021060422113004100_ref70","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1111\/j.1528-1157.1974.tb04022.x","article-title":"Persistent seizure susceptibility and recurrent spontaneous seizures in kindled cats","volume":"15","author":"Wada","year":"1974","journal-title":"Epilepsia"},{"key":"2021060422113004100_ref71","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/B978-0-12-804066-9.00040-7","volume-title":"Models of seizures and epilepsy","author":"Walker","year":"2017","edition":"2nd"},{"issue":"12","key":"2021060422113004100_ref72","doi-asserted-by":"crossref","first-page":"e0144113","DOI":"10.1371\/journal.pone.0144113","article-title":"Early-onset convulsive seizures induced by brain hypoxia-ischemia in aging mice: effects of anticonvulsive treatments","volume":"10","author":"Wang","year":"2015","journal-title":"PLoS One"},{"key":"2021060422113004100_ref73","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/0014-4886(79)90233-4","article-title":"Behavioral analysis of amygdala kindling in beagle dogs and the effects of clonazepam, diazepam, phenobarbital, diphenylhydantoin, and flunarizine on seizure manifestation","volume":"64","author":"Wauquier","year":"1979","journal-title":"Exp Neurol"},{"issue":"Pt 12","key":"2021060422113004100_ref74","doi-asserted-by":"crossref","first-page":"3796","DOI":"10.1093\/brain\/awt276","article-title":"Ictal high frequency oscillations distinguish two types of seizure territories in humans","volume":"136","author":"Weiss","year":"2013","journal-title":"Brain"},{"issue":"Pt 2","key":"2021060422113004100_ref75","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1113\/jphysiol.2006.114918","article-title":"Spontaneous rhythmic field potentials of isolated mouse hippocampal-subicular-entorhinal cortices in vitro","volume":"576","author":"Wu","year":"2006","journal-title":"J Physiol"},{"key":"2021060422113004100_ref76","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.1152\/jn.00806.2004","article-title":"Size does matter: generation of intrinsic network rhythms in thick mouse hippocampal slices","volume":"93","author":"Wu","year":"2005","journal-title":"J Neurophysiol"},{"key":"2021060422113004100_ref77","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.jneumeth.2008.03.001","article-title":"A glue-based, screw-free method for implantation of intra-cranial electrodes in young mice","volume":"171","author":"Wu","year":"2008","journal-title":"J Neurosci Methods"},{"key":"2021060422113004100_ref78","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.expneurol.2015.04.018","article-title":"Modeling early-onset post-ischemic seizures in aging mice","volume":"271","author":"Wu","year":"2015","journal-title":"Exp Neurol"},{"issue":"9","key":"2021060422113004100_ref79","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1016\/j.clinph.2017.05.020","article-title":"Temporal-spatial characteristics of phase-amplitude coupling in electrocorticogram for human temporal lobe epilepsy","volume":"128","author":"Zhang","year":"2017","journal-title":"Clin Neurophysiol"}],"container-title":["Cerebral Cortex Communications"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/cercorcomms\/article-pdf\/2\/1\/tgab004\/38487691\/tgab004.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/cercorcomms\/article-pdf\/2\/1\/tgab004\/38487691\/tgab004.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,5]],"date-time":"2021-06-05T00:39:10Z","timestamp":1622853550000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cercorcomms\/article\/doi\/10.1093\/texcom\/tgab004\/6106324"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,1]]},"references-count":75,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1,1]]}},"URL":"https:\/\/doi.org\/10.1093\/texcom\/tgab004","relation":{},"ISSN":["2632-7376"],"issn-type":[{"value":"2632-7376","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021]]},"published":{"date-parts":[[2021,1,1]]},"article-number":"tgab004"}}