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A typical representative compound of PAHs, 7,12-Dimethylbenz[a]anthracene (DMBA), was used to induce rat breast cancer. The results showed that therapeutic concentration of VPA (50 and 100\u00a0mg\/kg) delayed the occurrence of tumors, reduced tumor formation rate and attenuated tumors growth, and have a protective effect on normal tissues. The macrophage-mediated inflammatory response was found to be associated with the observed effect of VPA. In addition, we screened and validated a possible gene, Sema3c, which was involved in DMBA-induced breast cancer development and can be inhibited by VPA.<\/jats:p>","DOI":"10.1093\/toxres\/tfaa069","type":"journal-article","created":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T19:13:52Z","timestamp":1599074032000},"page":"609-621","source":"Crossref","is-referenced-by-count":3,"title":["The intervention of valproic acid on the tumorigenesis induced by an environmental carcinogen of PAHs"],"prefix":"10.1093","volume":"9","author":[{"given":"Junxuan","family":"Peng","sequence":"first","affiliation":[{"name":"Department of Occupational Health and Occupational Medicine, School of Public Health, Cheeloo College of Medicine, Shandong University, 44 Wenhua Xi Road, Shandong, Jinan, 250012, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zuchao","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Occupational Health and Occupational Medicine, School of Public Health, Cheeloo College of Medicine, Shandong University, 44 Wenhua Xi Road, Shandong, Jinan, 250012, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruixue","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Occupational Health and Occupational Medicine, School of Public Health, Cheeloo College of Medicine, Shandong University, 44 Wenhua Xi Road, Shandong, Jinan, 250012, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiahao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Occupational Health and Occupational Medicine, School of Public Health, Cheeloo College of Medicine, Shandong University, 44 Wenhua Xi Road, Shandong, Jinan, 250012, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guochao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Occupational Health and Occupational Medicine, School of Public 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