{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T13:21:33Z","timestamp":1780838493626,"version":"3.54.1"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2020,11,28]],"date-time":"2020-11-28T00:00:00Z","timestamp":1606521600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,1,5]]},"abstract":"<jats:title>Abstarct<\/jats:title><jats:p>Polyherbal compound (Bronco-T) has been extensively used as a traditional medicine for various therapies. However, very few report studies on anti-inflammatory and lung regeneration properties are evidenced. In the present study, we evaluated the beneficial actions and anti-inflammatory properties of polyherbal medicine, Bronco-T, exhibited by treating the lungs of rats exposed to formaldehyde to evaluate the beneficial properties. For this study, we divided into five groups\u2019: i.e. Group-I served as a control and the other four groups such as II, III, IV, and V are experimental. All animals maintained by regular feed and water ad libitum during the study. Formaldehyde vapors exposure at a single period of time (1\u00a0hour) daily (40%formaldehyde at room temperature) for 21\u00a0days period exposed all groups. The Bronco-T extracts about 50\u00a0mg\/kg BW administered to experimental groups and group IV rats treated with 500\u03bc grams\/Kg BW salbutamol. To understand the impact of formaldehyde exposure on the beneficial effects of Bronco-T, we evaluated hematological parameters, bronchoalveolar lavage (BAL), histamine levels, and histological alterations of lung architecture. Formaldehyde-induced adverse effects in lung and increased histamine levels in BAL compared to Bronco-T-treated rats act as a preventive immunological role in blood toxicity and recovery of lung architecture in Bronco-T-treated rats. This study showed the evaluation of antihistamine levels through HPLC analysis. Bronco-T has antioxidant and anti-histamine properties as the widest therapeutic window, and we continue to evaluate the pharmacological evaluations needed in our further studies.<\/jats:p>","DOI":"10.1093\/toxres\/tfaa083","type":"journal-article","created":{"date-parts":[[2020,10,15]],"date-time":"2020-10-15T19:38:51Z","timestamp":1602790731000},"page":"798-807","source":"Crossref","is-referenced-by-count":4,"title":["Beneficial effects of polyherbal formulation (Bronco-T) on formaldehyde-induced lung toxicity in male Wistar rats"],"prefix":"10.1093","volume":"9","author":[{"given":"Payani","family":"Sholapuri","sequence":"first","affiliation":[{"name":"Department of Zoology, SVU College of Sciences, Sri Venkateswara University, Tirupati 517 502, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venkataramaiah","family":"Chintha","sequence":"additional","affiliation":[{"name":"Department of Zoology, SVU College of Sciences, Sri Venkateswara University, Tirupati 517 502, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhaskar","family":"Matcha","sequence":"additional","affiliation":[{"name":"Department of Zoology, SVU College of Sciences, Sri Venkateswara University, Tirupati 517 502, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JangampalliAdi","family":"Pradeepkiran","sequence":"additional","affiliation":[{"name":"Department of Zoology, SVU College of Sciences, Sri Venkateswara University, Tirupati 517 502, Andhra Pradesh, India"},{"name":"Department of Internal Medicine, Texas Tech University of Health Science Centre, Lubbock 79413, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,11,28]]},"reference":[{"key":"2021010603301651100_ref1","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1002\/(SICI)1097-0274(199803)33:3<274::AID-AJIM9>3.0.CO;2-W","article-title":"Airway response to formaldehyde inhalation in asthmatic subjects with suspected respiratory formaldehyde sensitization","volume":"33","author":"Krakowiak","year":"1998","journal-title":"Am J Ind Med"},{"key":"2021010603301651100_ref2","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1111\/j.1365-2222.2003.01826.x","article-title":"Potentiation of allergic bronchoconstriction by repeated exposure to formaldehyde in Guinea-pigs in vivo","volume":"33","author":"Kita","year":"2003","journal-title":"Clin Exp Allergy"},{"key":"2021010603301651100_ref3","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1289\/ehp.7830","article-title":"Latex-induced occupational asthma in a surgical pathologist","volume":"113","author":"Green-Mckenzie","year":"2005","journal-title":"Environ. 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