{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T11:36:07Z","timestamp":1784115367411,"version":"3.55.0"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,2,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Traumatic brain injury (TBI) is an insult to the brain from an external mechanical force, leading to temporary\/permanent secondary injuries, i.e. impairment of cognitive, physical, and psycho-social functions with altered consciousness. The leading mechanism responsible for neuronal damage following TBI is an increase in oxidative reactions initiated by free radicals generated by the injury along with various other mechanisms. Nerolidol is reported to have potent antioxidant and anti-neuroinflammatory properties. The present study was designed to explore the neuroprotective effect of nerolidol in weight-drop-induced TBI in rats. Animals were injured on the 1st day by dropping a free-falling weight of 200 gm from a height of 1\u00a0m through a guide pipe onto the exposed skull. After 14\u00a0days of injury, nerolidol (25, 50, and 100\u00a0mg\/kg, i.p.) treatment was given for the next 14\u00a0days. Locomotor activity and motor coordination were evaluated using an actophotometer and rotarod, respectively. Cognitive impairment was observed through the Morris Water Maze and Object Recognition Test. On the 29th day, animals were sacrificed, and their brains were collected for the biochemical estimation. The weight drop model significantly decreased locomotor activity, motor coordination, increased Acetylcholinesterase (AChE) activity, oxidative stress, and induced cognitive deficits in TBI rats. Nerolidol significantly improved locomotor activity, reversed motor incoordination and cognitive impairment, and reduced the AChE activity and oxidative\/nitrosative stress. The present study demonstrates the promising neuroprotective effects of nerolidol, which might improve the quality of life of TBI patients.<\/jats:p>","DOI":"10.1093\/toxres\/tfaa100","type":"journal-article","created":{"date-parts":[[2020,11,26]],"date-time":"2020-11-26T20:10:25Z","timestamp":1606421425000},"page":"40-50","source":"Crossref","is-referenced-by-count":22,"title":["Neuroprotective effect of nerolidol in traumatic brain injury associated behavioural comorbidities in rats"],"prefix":"10.1093","volume":"10","author":[{"given":"Amandeep","family":"Kaur","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences and Technology, Maharaja Ranjit Singh Punjab Technical University, Bathinda-151001 (Punjab), India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5972-8130","authenticated-orcid":false,"given":"Gagandeep","family":"Jaiswal","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences and Technology, Maharaja Ranjit Singh Punjab Technical University, Bathinda-151001 (Punjab), India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasdeep","family":"Brar","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences and Technology, Maharaja Ranjit Singh Punjab Technical University, Bathinda-151001 (Punjab), India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Puneet","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences and Technology, Maharaja Ranjit Singh Punjab Technical University, Bathinda-151001 (Punjab), India"},{"name":"Department of Pharmacology, Central University of Punjab, Bathinda-151001 (Punjab), India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,1,5]]},"reference":[{"key":"2021031514094554500_ref1","first-page":"97","article-title":"Neuroinflammatory responses to traumatic brain injury: etiology, clinical consequences, and therapeutic opportunities","volume":"11","author":"Lozano","year":"2015","journal-title":"Neuropsychiatr Dis Treat"},{"key":"2021031514094554500_ref2","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1097\/MAJ.0000000000000506","article-title":"Traumatic brain injury and mitochondrial dysfunction","volume":"350","author":"Hiebert","year":"2015","journal-title":"Am J Med Sci"},{"key":"2021031514094554500_ref3","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/978-1-4939-9465-6_4","article-title":"Neuroprotection in traumatic brain injury","volume-title":"The Handbook of Neuroprotection","author":"Jain","year":"2019"},{"key":"2021031514094554500_ref4","first-page":"0","article-title":"Traumatic brain injury","volume":"27","author":"P\u00edculo","year":"2018","journal-title":"Neurosurg Clin N Am"},{"key":"2021031514094554500_ref5","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.neuropharm.2018.06.005","article-title":"Secondary brain injury: predicting and preventing insults","volume":"145","author":"Lazaridis","year":"2019","journal-title":"Neuropharmacology"},{"key":"2021031514094554500_ref6","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.neuropharm.2018.08.005","article-title":"Newer pharmacological approaches for antioxidant neuroprotection in traumatic brain injury","volume":"145","author":"Hall","year":"2019","journal-title":"Neuropharmacology"},{"key":"2021031514094554500_ref7","first-page":"115","volume-title":"Handbook of clinical neurology","author":"Johnson","year":"2015"},{"key":"2021031514094554500_ref8","doi-asserted-by":"crossref","first-page":"192","DOI":"10.2174\/2211556007666180601100641","article-title":"Protective effect of agomelatine on traumatic brain injury induced cognitive deficit in rats: possible role of neurotransmitters","volume":"7","author":"Kaur","year":"2018","journal-title":"Curr Psychopharmacol"},{"key":"2021031514094554500_ref9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12868-016-0293-4","article-title":"Neuroprotective effect of nerolidol against neuroinflammation and oxidative stress induced by rotenone","volume":"17","author":"Javed","year":"2016","journal-title":"BMC Neurosci"},{"key":"2021031514094554500_ref10","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1080\/14786419.2014.918121","article-title":"Does antioxidant properties of the main component of essential oil reflect its antioxidant properties? 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