{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T15:12:54Z","timestamp":1791213174687,"version":"4.1.0"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2021,4,12]],"date-time":"2021-04-12T00:00:00Z","timestamp":1618185600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"National Natural Science Foundation Project","award":["51672004"],"award-info":[{"award-number":["51672004"]}]},{"name":"Anhui Natural Science Foundation Project","award":["1608085MH176"],"award-info":[{"award-number":["1608085MH176"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,6,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Di(2-ethylhexyl) phthalate (DEHP), as an endocrine disruptor, is often used as a plasticizer in various polyvinyl chloride plastic products and medical consumables. Epidemiological studies have shown that long-term large intake of DEHP may be a risk factor for liver dysfunction. Long-term exposure to DEHP is associated with liver disease and aggravates the progression of chronic liver injury. However, the effects of DEHP on hepatocellular carcinoma (HCC) are rarely studied. In this study, we sought to determine the effects of DEHP on HCC induced by carbon tetrachloride combined with diethylnitrosamine, and further study its molecular mechanism. It was found that DEHP exposure significantly promotes tumor immune escape and activates signaling pathways involved in related protein expression of tumor immune escape, including PD-L1, JAK2, and STAT3. In addition, the trends observed in the HepG2 cells assay are consistent with vivo conditions. In summary, DEHP may play a tumor-promoting role in HCC mice and IFN-\u03b3 stimulated HepG2 cells, which may be related to the JAK2\/STAT3 signaling pathway.<\/jats:p>","DOI":"10.1093\/toxres\/tfab018","type":"journal-article","created":{"date-parts":[[2021,4,11]],"date-time":"2021-04-11T20:06:29Z","timestamp":1618171589000},"page":"376-388","source":"Crossref","is-referenced-by-count":19,"title":["Promotion effects of DEHP on hepatocellular carcinoma models: up-regulation of PD-L1 by activating the JAK2\/STAT3 pathway"],"prefix":"10.1093","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6453-3189","authenticated-orcid":false,"given":"Qiang","family":"Xu","sequence":"first","affiliation":[{"name":"Key Laboratory of Anti-inflammatory and Immune Medicine of Education Ministry, Anhui Collaborative Innovation Center of Anti-inflammatory and Immune Medicine, Institute of Clinical Pharmacology of Anhui Medical University, No. 81 Meishan Road, Hefei, Anhui 230032, 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University, No. 81 Meishan Road, Hefei, Anhui 230032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Life Sciences and Medicine, Anhui Provincial Key Laboratory of Tumor Immunotherapy and Nutrition Therapy, The First Affiliated Hospital of USTC, University of Science and Technology of China, No 17 Lujiang Road, Hefei, Anhui 230001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Ping","family":"Xu","sequence":"additional","affiliation":[{"name":"Division of Life Sciences and Medicine, Anhui Provincial Key Laboratory of Tumor Immunotherapy and Nutrition Therapy, The First Affiliated Hospital of USTC, University of Science and Technology of China, No 17 Lujiang Road, Hefei, Anhui 230001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wei","sequence":"additional","affiliation":[{"name":"Key Laboratory of 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