{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T19:38:42Z","timestamp":1740166722179,"version":"3.37.3"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2021,4,29]],"date-time":"2021-04-29T00:00:00Z","timestamp":1619654400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"National Science Foundation for Post-doctoral Scientists of China","award":["2019M653672"],"award-info":[{"award-number":["2019M653672"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81930096","81704088"],"award-info":[{"award-number":["81930096","81704088"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,6,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Imidazolidinyl urea (IU) is used as an antimicrobial preservative in cosmetic and pharmaceutical products. IU induces allergic contact dermatitis, however, the mechanism has not yet been elucidated. Mas-related G protein-coupled receptor-X2 (MRGPRX2) triggers drug-induced pseudo-allergic reactions. The aims of this study were to determine whether IU activated mast cells through MRGPRX2 to further trigger contact dermatitis. Wild-type (WT) and KitW-sh\/HNihrJaeBsmJNju (MUT) mice were treated with IU to observe its effects on local inflammation and mast cells degranulation in vivo. Laboratory of allergic disease 2 cells were used to detect calcium mobilization and release of inflammatory mediators in vitro. WT mice showed a severe local inflammatory response and contact dermatitis, whereas only slight inflammatory infiltration was observed in MUT mice. Thus, MRGPRX2 mediated the IU-induced activation of mast cells. However, histamine, a typical allergen, was not involved in this process. Tryptase expressed by mast cells was the major non-histaminergic inflammatory mediator of contact dermatitis. IU induced anaphylactic reaction via MRGPRX2 and further triggering non-histaminergic contact dermatitis, which explained why antihistamines are clinically ineffective against some chronic dermatitis.<\/jats:p>","DOI":"10.1093\/toxres\/tfab035","type":"journal-article","created":{"date-parts":[[2021,4,29]],"date-time":"2021-04-29T07:16:03Z","timestamp":1619680563000},"page":"467-475","source":"Crossref","is-referenced-by-count":1,"title":["Imidazolidinyl urea activates mast cells via MRGPRX2 to induce non-histaminergic allergy"],"prefix":"10.1093","volume":"10","author":[{"given":"Jiapan","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical analysis, School of Pharmacy, Xi\u2019an Jiaotong University, 76, Yanta west road, Xi\u2019an, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Delu","family":"Che","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Northwest Hospital, The Second Hospital Affiliated to Xi\u2019an Jiaotong University, 157, Xiwu road, Xi\u2019an, Shaanxi, China"},{"name":"Center for Dermatology Disease, Precision Medical Institute, East Yinxing Road, Xi\u2019an, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueshan","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Northwest Hospital, The Second Hospital Affiliated to Xi\u2019an Jiaotong University, 157, Xiwu road, Xi\u2019an, Shaanxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Northwest Hospital, The Second Hospital Affiliated to Xi\u2019an Jiaotong University, 157, Xiwu road, Xi\u2019an, Shaanxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huiling","family":"Jing","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Xi'an Hospital of Traditional Chinese Medicine, 69, Fengcheng 8th Road, Xi\u2019an, Shaanxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical analysis, School of Pharmacy, Xi\u2019an Jiaotong University, 76, Yanta west road, Xi\u2019an, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,4,29]]},"reference":[{"key":"2021070810591572700_ref1","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1600-0536.2009.01615.x","article-title":"Formaldehyde-releasers in cosmetics: relationship to formaldehyde contact allergy. 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