{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T15:25:01Z","timestamp":1791473101461,"version":"4.3.4"},"reference-count":73,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T00:00:00Z","timestamp":1648684800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Researchers Support Project","award":["TURSP-2020\/09"],"award-info":[{"award-number":["TURSP-2020\/09"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,4,28]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study examined if wheat germ oil (WGO) has gastroprotective impacts against ethanol-induced gastric ulcer in rats. Rats were assigned into control, WGO, ethanol, omeprazole + ethanol, and WGO\u00a0+\u00a0ethanol. WGO prevented gastric ulceration and damage induced by ethanol, the same effect induced by omeprazole, a widely known medication used for gastric ulcer treatment. WGO reduced gastric ulcer index, nitric oxide, and malondialdehyde levels in the stomach. WGO boosted the expression of nuclear factor erythroid 2-related factor 2 (Nrf2), heme oxygenase-1 (HO-1), Bcl2, and the antioxidants. WGO showed inflammatory and anti-inflammatory impacts through the control of interleukin (IL)-1\u03b2, Tumor necrosis factor alpha (TNF-\u03b1), and IL-10 that were altered in ethanol-administered rats. Ethanol up-regulated caspase-3 and nuclear factor-kappa B (NF-kB) expression and showed histopathological changes such as necrosis and mucosal degeneration that were mitigated by pre-administration of WGO. Moreover, WGO decreased gastric immunoreactivity of NF-kB and increased transforming growth factor beta-1 (TGF-\u03b21) that were associated with upregulation of Nrf2, heme oxygenase-1 (HO-1), and antioxidant expression and production. In conclusion, WGO reduced ethanol-induced stomach toxicity by regulating genes involved in oxidative stress, inflammation, and apoptotic\/antiapoptotic pathways.<\/jats:p>","DOI":"10.1093\/toxres\/tfac012","type":"journal-article","created":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T20:09:36Z","timestamp":1646165376000},"page":"325-338","source":"Crossref","is-referenced-by-count":13,"title":["The ameliorative impacts of wheat germ oil against ethanol-induced gastric ulcers: involvement of anti-inflammatory, antiapoptotic, and antioxidant activities"],"prefix":"10.1093","volume":"11","author":[{"given":"Rabab Shaban","family":"El-shafey","sequence":"first","affiliation":[{"name":"Department of Forensic Medicine & Clinical Toxicology, Faculty of Medicine, Benha University, Benha 13511, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samar H","family":"Baloza","sequence":"additional","affiliation":[{"name":"Genetic and Genetic Engineering, Animal Wealth Development Department, Faculty of Veterinary Medicine, Benha University, Benha 13736, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina Abdelhady","family":"Mohammed","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry and Molecular Biology, College of Medicine, Benha University, Benha 13511, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hend Elsayed","family":"Nasr","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry and Molecular Biology, College of Medicine, Benha University, Benha 13511, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed Mohamed","family":"Soliman","sequence":"additional","affiliation":[{"name":"Clinical Laboratory Sciences Department, Turabah University College, Taif University, PO Box 11099, Taif 21944, Taif, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heba I","family":"Ghamry","sequence":"additional","affiliation":[{"name":"Department of Home Economics, College of Home Economics, King Khalid University, P.O. 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