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Toxicological assessment includes exposure scenario (e.g. environmental, occupational), route of exposure, toxicokinetics, and toxicodynamics. Broader considerations include pathology, risk assessment, regulation, and treatment after injury. This review aims to consolidate the most relevant and up-to-date research in these areas to provide an exhaustive toxicological profile of silica nanoparticles.<\/jats:p>","DOI":"10.1093\/toxres\/tfac038","type":"journal-article","created":{"date-parts":[[2022,7,18]],"date-time":"2022-07-18T15:29:44Z","timestamp":1658158184000},"page":"565-582","source":"Crossref","is-referenced-by-count":78,"title":["A toxicological profile of silica nanoparticles"],"prefix":"10.1093","volume":"11","author":[{"given":"James Y","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Environmental Science , Baylor University, One Bear Place # 97266, Waco, TX 76798-7266 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5529-4101","authenticated-orcid":false,"given":"Christie M","family":"Sayes","sequence":"additional","affiliation":[{"name":"Department of Environmental Science , Baylor University, One Bear Place # 97266, Waco, TX 76798-7266 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,7,16]]},"reference":[{"key":"2022083004375401000_ref1","author":"Williams","year":"2019"},{"key":"2022083004375401000_ref2","author":"EPA","year":"1996"},{"key":"2022083004375401000_ref3","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.disamonth.2007.09.020","article-title":"Silicosis: a review","volume":"53","author":"Greenberg","year":"2007","journal-title":"Dis Mon"},{"key":"2022083004375401000_ref4","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.fct.2017.05.054","article-title":"Nanoengineered silica: properties, applications and toxicity","volume":"109","author":"Mebert","year":"2017","journal-title":"Food Chem Toxicol"},{"issue":"9","key":"2022083004375401000_ref5","doi-asserted-by":"crossref","first-page":"2967","DOI":"10.1007\/s00204-017-1993-y","article-title":"Toxicology of silica nanoparticles: an 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