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Flubromazepam\u2014a designer benzodiazepine\u2014is a long-acting gamma-aminobutyric acid subtype A receptor agonist. There is currently a lack of scientific evidence regarding the potential for flubromazepam dependence or other adverse effects. This study aimed to evaluate the dependence potential, and cardiotoxicity via confirmation of the QT and RR intervals which are the factors on the electrical properties of the heart of flubromazepam in rodents. Using a conditioned place preference test, we discovered that mice treated intraperitoneally with flubromazepam (0.1\u00a0mg\/kg) exhibited a significant preference for the flubromazepam-paired compartment, suggesting a potential for flubromazepam dependence. In addition, we observed several cardiotoxic effects of flubromazepam; 100-\u03bcM flubromazepam reduced cell viability, increased RR intervals but not QT intervals in the electrocardiography measurements, and considerably inhibited potassium channels in a human ether-\u00e0-go-go-related gene assay. Collectively, these findings suggest that flubromazepam may have adverse effects on psychological and cardiovascular health, laying the foundation for further efforts to list flubromazepam as a controlled substance at both national and international levels.<\/jats:p>","DOI":"10.1093\/toxres\/tfac039","type":"journal-article","created":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T21:37:18Z","timestamp":1657229838000},"page":"644-653","source":"Crossref","is-referenced-by-count":2,"title":["The designer benzodiazepine, flubromazepam, induces reward-enhancing and cardiotoxic effects in rodents"],"prefix":"10.1093","volume":"11","author":[{"given":"Eunchong","family":"Hong","sequence":"first","affiliation":[{"name":"College of Pharmacy , Chungbuk National University, 194-31 Osongsaengmyeong 1-ro, Osong-eup, Heungdeok-gu, Cheongju-si, Chungcheongbuk-do 28160, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sun 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