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Previously, we tested the antiparasitic activity of a number of imidazo[1,2-a]pyridine derivatives (IMPYs) on metronidazole-resistant strains of Entamoeba Hystolitica (HM1:IMSS), and Trichomonas Vaginalis (GT3). Their anti-inflammatory activity was also evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The present work is a part of a project whose aim is to find new alternatives to standard treatments for these maladies, and to address the current concern of emerging resistant parasite strains. Here we report a non-clinical study focused on exploratory toxicology assays of seven IMPYs that showed the best antiparasitic and\/or anti-inflammatory properties.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Acute, and subacute toxicity tests were carried out. After 14-day oral treatment, liver and kidney functionality assays in combination with chemometric methods were implemented to detect hepatic and\/or kidney damage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Some compounds produced off-target effects. Vehicle effects were also detected. However, no signs of hepatic or renal toxicity were observed for any IMPY.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These compounds can continue non-clinical evaluations, and if possible, clinical trials as new candidates to treat trichomoniasis and amoebiasis, and inflammatory diseases. Further studies are also needed to fully elucidate a proposed dual effect that may exert these molecules against trichomoniasis and amoebiasis, which may also signify a novel mechanism of action to treat these infections.<\/jats:p><\/jats:sec>","DOI":"10.1093\/toxres\/tfac046","type":"journal-article","created":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T07:49:02Z","timestamp":1660117742000},"page":"730-742","source":"Crossref","is-referenced-by-count":4,"title":["Exploratory toxicology studies of 2,3-substituted imidazo[1,2-<i>a<\/i>]pyridines with antiparasitic and anti-inflammatory properties"],"prefix":"10.1093","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8669-7571","authenticated-orcid":false,"given":"Jos\u00e9 Iv\u00e1n","family":"Serrano-Contreras","sequence":"first","affiliation":[{"name":"Departamento de Qu\u00edmica Org\u00e1nica , Escuela Nacional de Ciencias Biol\u00f3gicas, , Ciudad de M\u00e9xico, M\u00e9xico"},{"name":"Instituto Polit\u00e9cnico Nacional, Prolongaci\u00f3n de Carpio y Plan de Ayala s\/n, Col. 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Wilfrido Massieu 399, Unidad Profesional Adolfo L\u00f3pez Mateos, Col. Nueva Industrial Vallejo, C.P. 07738, Delegaci\u00f3n Gustavo A. Madero , Escuela Nacional de Ciencias Biol\u00f3gicas, , Ciudad de M\u00e9xico, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0132-3149","authenticated-orcid":false,"given":"Yazm\u00edn Karina","family":"M\u00e1rquez-Flores","sequence":"additional","affiliation":[{"name":"Departamento de Farmacia , Escuela Nacional de Ciencias Biol\u00f3gicas, , Ciudad de M\u00e9xico, M\u00e9xico"},{"name":"Instituto Polit\u00e9cnico Nacional, Av. Wilfrido Massieu 399, Unidad Profesional Adolfo L\u00f3pez Mateos, Col. Nueva Industrial Vallejo, C.P. 07738, Delegaci\u00f3n Gustavo A. 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