{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:34:50Z","timestamp":1787009690335,"version":"build-2736575974"},"reference-count":70,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2023,2,9]],"date-time":"2023-02-09T00:00:00Z","timestamp":1675900800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Tunisian Ministry of Higher Education, Scientific Research and Technology"},{"name":"Laboratory of Biotechnology and Biomonitoring of the Environment and Oasis Ecosystems"},{"name":"Faculty of Sciences of Gafsa, University of Gafsa, Tunisia"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,4,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The objectives of the current study were to evaluate the Punica granatum root bark extract\u2019s (PGE) antioxidant and gastroprotective activities against ethanol-induced gastric ulcers in Wistar rats and to elucidate the putative mechanism of action using in silico analysis. The PGE phytochemical study shows high levels of phenolics, flavonoids, tannins, and polysaccharides. In vitro, the PGE was more effective at scavenging hydroxyl radicals than quercetin and had lower ferric reducing activity than catechin. In vivo, it was revealed that pretreatment of ethanol-ulcerated rats with PGE at oral doses of 100, 200, and 400\u00a0mg\/kg b.w. offered a dose-dependent shield against ethanol-induced ulcers when compared to Omeprazole (20\u00a0mg\/kg b.w.) by preventing the development of deep ulcer lesions, lowering gastric juice output and pH rises, boosting gastric mucus production and antioxidant enzyme levels, and attenuating malondialdehyde and myeloperoxidase contents. Moreover, the liquid chromatography\u2013mass spectrometry analysis of PGE identified 5 phenolic acids and 4 flavonoids, which revealed an in silico high oral bioavailability, drug-likenesses, and good binding affinities and thus inhibitory effects on the gastric H+, K+-ATPase enzyme. PGE may have synergistic antioxidant, anti-inflammatory, and H+, K+-proton pump inhibitory actions that contribute to its antiulcer efficacy.<\/jats:p>","DOI":"10.1093\/toxres\/tfad006","type":"journal-article","created":{"date-parts":[[2023,1,28]],"date-time":"2023-01-28T02:39:13Z","timestamp":1674873553000},"page":"189-200","source":"Crossref","is-referenced-by-count":4,"title":["LC\u2013ESI\u2013MS phenolic contents assessment, antioxidant, and protective ability of\n                    <i>Punica granatum<\/i>\n                    root bark extract against ethanol-induced gastric ulcer in rats:\n                    <i>in silico<\/i>\n                    H+, K+-ATPase inhibitory pathway study"],"prefix":"10.1093","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4881-1035","authenticated-orcid":false,"given":"Hichem","family":"Alimi","sequence":"first","affiliation":[{"name":"Laboratory of Biotechnology and Biomonitoring of the Environment and Oasis Ecosystems , Faculty of Sciences of Gafsa, , 2112 Gafsa , Tunisia"},{"name":"University of Gafsa , Faculty of Sciences of Gafsa, , 2112 Gafsa , Tunisia"},{"name":"Laboratory of Integrated Physiology , Faculty of Science of Bizerte, , 7021 Jarzouna, Bizerte , Tunisia"},{"name":"University of Carthage Tunisia , Faculty of Science of Bizerte, , 7021 Jarzouna, Bizerte , Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faten Haj","family":"Mabrouk","sequence":"additional","affiliation":[{"name":"Laboratory of Biotechnology and Biomonitoring of the Environment and Oasis Ecosystems , Faculty of Sciences of Gafsa, , 2112 Gafsa , Tunisia"},{"name":"University of Gafsa , Faculty of Sciences of Gafsa, , 2112 Gafsa , Tunisia"},{"name":"Laboratory of Integrated Physiology , Faculty of Science of Bizerte, , 7021 Jarzouna, Bizerte , Tunisia"},{"name":"University of Carthage Tunisia , Faculty of Science of Bizerte, , 7021 Jarzouna, Bizerte , Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nacim","family":"Zouari","sequence":"additional","affiliation":[{"name":"Unit of Functional Physiology and Valorization of Bio-Resources , University of Jendouba, , 9000 B\u00e9ja , Tunisia"},{"name":"Higher Institute of Biotechnology of B\u00e9ja , University of Jendouba, , 9000 B\u00e9ja , Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8980-3712","authenticated-orcid":false,"given":"Mohsen","family":"Sakly","sequence":"additional","affiliation":[{"name":"Laboratory of Integrated Physiology , Faculty of Science of Bizerte, , 7021 Jarzouna, Bizerte , Tunisia"},{"name":"University of Carthage Tunisia , Faculty of Science of Bizerte, , 7021 Jarzouna, Bizerte , Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kh\u00e9mais Ben","family":"Rhouma","sequence":"additional","affiliation":[{"name":"Laboratory of Integrated Physiology , Faculty of Science of Bizerte, , 7021 Jarzouna, Bizerte , Tunisia"},{"name":"University of Carthage Tunisia , Faculty of Science of Bizerte, , 7021 Jarzouna, Bizerte , Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,2,9]]},"reference":[{"key":"2023042811482715800_ref1","doi-asserted-by":"crossref","first-page":"114115","DOI":"10.1016\/j.jep.2021.114115","article-title":"Anti-ulcerogenic effect of methanolic extract of Elaeagnus conferta Roxb. seeds in Wistar rats","volume":"275","author":"Gupta","year":"2021","journal-title":"J Ethnopharmacol"},{"key":"2023042811482715800_ref2","doi-asserted-by":"crossref","first-page":"114626","DOI":"10.1016\/j.jep.2021.114626","article-title":"Effectiveness of the fruit of Rosa odorata sweet var. gigantea (Coll. et Hemsl.) 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