{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T03:19:03Z","timestamp":1788319143089,"version":"build-2803163510"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2023,7,3]],"date-time":"2023-07-03T00:00:00Z","timestamp":1688342400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,8,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The objective of the study was to assess the demographics, clinical parameters, and outcome of acute intoxications among adult patients admitted to a medical intensive care unit in southern Croatia.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Materials and Methods<\/jats:title>\n                  <jats:p>An observational retrospective study was conducted over a 1-year period. The subjects were patients admitted to the intensive care unit for acute poisoning.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In all, 81 subjects (32.1% females) aged 43.16\u00a0\u00b1\u00a014.77\u00a0years were admitted to the intensive care unit because of poisoning (14.97% of the total annual intensive care unit admissions). Psychiatric disorders were previously established in 76.5% participants, and 69.1% of all acute intoxications were classified as suicidal. Non-suicidal subjects differed from suicidal subjects in age (37.36\u00a0\u00b1\u00a09.71 vs. 45.75\u00a0\u00b1\u00a015.93\u00a0years; P\u00a0=\u00a00.009), in pCO2 (6.38\u00a0\u00b1\u00a01.78 vs. 5.50\u00a0\u00b1\u00a01.26\u00a0kPa; P\u00a0=\u00a00.020), in length-of-stay in intensive care unit (median 1.00, interquartile range 1.00 vs. median 2.00, interquartile range 2.00\u00a0days; P\u00a0=\u00a00.022), and in length-of-stay in hospital (median 2.00, interquartile range 2.00 vs. median 10.50, interquartile range 15.25\u00a0days; P\u00a0&amp;lt;\u00a00.001). Three (3.7%) patients died. Pharmaceutical psychoactive drug intoxications were the most common poisoning cases; of these, diazepam was the most frequent (16.8%), followed by ethanol (9.0%) and alprazolam (7.8%). Benzodiazepines\/hypnotics were the most common group (28.7%), followed by antipsychotics (13.2%). Intoxications with more than 1 poison accounted for the largest number of cases (67.9%). The number of toxins was significantly correlated with length-of-stay in the hospital (rho\u00a0=\u00a0\u22120.265; P\u00a0=\u00a00.008), systolic blood pressure (rho\u00a0=\u00a0\u22120.318; P\u00a0=\u00a00.002), and diastolic blood pressure (rho\u00a0=\u00a0\u22120.262; P\u00a0=\u00a00.009). The electrocardiogram was considered abnormal in 50.62% of the cases.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Acute intoxicants were most commonly caused by psychiatric pharmaceutical drugs. Multidrug exposure was a typical pattern of acute intoxication.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/toxres\/tfad054","type":"journal-article","created":{"date-parts":[[2023,6,22]],"date-time":"2023-06-22T23:37:25Z","timestamp":1687477045000},"page":"626-634","source":"Crossref","is-referenced-by-count":8,"title":["Clinical and demographic features with outcome predictors of adult patients with acute intoxication admitted to a medical intensive care unit in the Mediterranean part of Croatia"],"prefix":"10.1093","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9854-2611","authenticated-orcid":false,"given":"Vedran","family":"Kovacic","sequence":"first","affiliation":[{"name":"University Hospital of Split Internal Medicine Department, Division of Emergency and Intensive Medicine with Clinical Pharmacology and Toxicology, , 21000 Split , 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Split Internal Medicine Department, Division of Emergency and Intensive Medicine with Clinical Pharmacology and Toxicology, , 21000 Split , Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Maras","sequence":"additional","affiliation":[{"name":"University Hospital of Split Internal Medicine Department, Division of Emergency and Intensive Medicine with Clinical Pharmacology and Toxicology, , 21000 Split , Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jurica","family":"Nazlic","sequence":"additional","affiliation":[{"name":"University Hospital of Split Internal Medicine Department, Division of Emergency and Intensive Medicine with Clinical Pharmacology and Toxicology, , 21000 Split , 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