{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:24:49Z","timestamp":1773707089473,"version":"3.50.1"},"reference-count":53,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T00:00:00Z","timestamp":1695168000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Provincial and Ministerial Major Project of China","award":["552021CR0030"],"award-info":[{"award-number":["552021CR0030"]}]},{"name":"Provincial and Ministerial Major Project of China","award":["110202102011"],"award-info":[{"award-number":["110202102011"]}]},{"name":"Provincial and Ministerial Major Project of China","award":["2019420000340623"],"award-info":[{"award-number":["2019420000340623"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,10,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Researches have shown that chronic inhalation of cigarette smoke (CS) disrupts male reproductive system, but it is unclear about the mechanisms behind reproductive damages by tobacco toxicants in male rats. This study was designed to explore the effects of heated tobacco products (HTP) aerosols and CS exposure on the testicular health of rats.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Materials and Methods<\/jats:title>\n                  <jats:p>Experiments were performed on male SD rats exposed to filtered air, HTP aerosols at 10 \u03bcg\/L, 23 \u03bcg\/L, and 50 \u03bcg\/L nicotine-equivalent contents, and also CS at 23 \u03bcg\/L nicotine-equivalent content for 90 days in five exposure groups (coded as sham, HTP_10, HTP_23, HTP_50 and Cig_23). The expression of serum testosterone, testicular tissue inflammatory cytokines (IL-1\u03b2, IL-6, IL-10, TNF-\u03b1), reactive oxygen species (ROS), superoxide dismutase (SOD) and malondialdehyde (MDA), NLRP3 inflammasome-related mRNAs and proteins (NLRP3, ASC, and Caspase-1), the degree of pyroptosis and histopathology were investigated.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The results demonstrated that HTP_50 and Cig_23 caused varying degrees of oxidative damage to rat testis, resulting in a decrease of sperm quantity and serum testosterone contents, an increase in the deformity rate, expression levels of proinflammatory cytokines, and NLRP3 inflammasome-related mRNA, and an increase in the NLRP3, ASC, and Caspase-1-immunopositive cells, pyroptosis cell indices, and histopathological damage in the testes of rats. Responses from the HTP_10 and HTP_23 groups were less than those found in the above two exposure groups.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>These findings indicate that HTP_50 and Cig_23 induced oxidative stress in rat testes, induced inflammation and pyroptosis through the ROS\/NLRP3\/Caspase-1 pathway, and destroyed the integrity of thetesticular tissue structure.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/toxres\/tfad085","type":"journal-article","created":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T19:32:09Z","timestamp":1695411129000},"page":"902-912","source":"Crossref","is-referenced-by-count":12,"title":["Testicular tissue response following a 90-day subchronic exposure to HTP aerosols and cigarette smoke in rats"],"prefix":"10.1093","volume":"12","author":[{"given":"Hongjuan","family":"Wang","sequence":"first","affiliation":[{"name":"Beijing 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