{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T13:05:30Z","timestamp":1765976730688,"version":"3.37.3"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>A broad spectrum carbamate fungicide called carbendazim (Carb) is used to combat a number of different fungal diseases. One of the extensively utilized medicinal plants in oriental countries is Coriandrum sativum.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Aim<\/jats:title>\n                  <jats:p>In the current study, the impact of C. sativum seeds extract (CSE) on albino rats\u2019 testicular toxicity caused by carbendazim was investigated.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Materials and methods<\/jats:title>\n                  <jats:p>A total of 50 male albino rats were classified into 5 groups [Gp1, Control Gp; Gp2, Coriandrum Gp (CSE); Gp 3, carbendazim Gp (Carb); Gp 4, Co treated CSE with Carb (CSE\u00a0+\u00a0Carb); Gp 5, Post treated Carb with CSE (Carb\u00a0+\u00a0CSE)].<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Carb induced elevation in serum LH. FSH, testicular malondialdehyde (MDA), testicular nitric oxide (NO) markers and testicular injury and it reduced serum testosterone, testicular glutathione (GSH), testicular catalase and PCNA. Treatments of Carb with CSE (CSE\u00a0+\u00a0Carb and\/or Carb\u00a0+\u00a0CSE) improved these parameters and reduced testicular toxicity with best results for Carb\u00a0+\u00a0CSE than CSE\u00a0+\u00a0Carb.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The above findings revealed that; Carb induced testicular toxicity and it supported the hypothesis that the antioxidant characteristics of one or more of CSE constituents can reduce the testicular toxicity of Carb.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/toxres\/tfad109","type":"journal-article","created":{"date-parts":[[2023,12,2]],"date-time":"2023-12-02T02:52:22Z","timestamp":1701485542000},"page":"1152-1158","source":"Crossref","is-referenced-by-count":2,"title":["Impact of <i>Coriandrum sativum<\/i> seeds extract on albino rats\u2019 testicular toxicity caused by carbendazim"],"prefix":"10.1093","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9722-3603","authenticated-orcid":false,"given":"Ehab","family":"Tousson","sequence":"first","affiliation":[{"name":"Department of Zoology , Faculty of Science, , Egypt"},{"name":"Tanta University , Faculty of Science, , Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Somaya Y","family":"Shalaby","sequence":"additional","affiliation":[{"name":"Department of Zoology , Faculty of Science, , Egypt"},{"name":"Menoufia University , Faculty of Science, , Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doaa M","family":"El-Gharbawy","sequence":"additional","affiliation":[{"name":"Forensic Medicine and Clinical Toxicology Department , Faculty of Medicine, , Egypt"},{"name":"Tanta University , Faculty of Medicine, , Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed A","family":"Akela","sequence":"additional","affiliation":[{"name":"Department of Biology , College of Science and Humanities in Al-Kharj, , Al-Kharj 11942 , Saudi Arabia"},{"name":"Prince Sattam bin Abdulaziz University , College of Science and Humanities in Al-Kharj, , Al-Kharj 11942 , Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Rabea","sequence":"additional","affiliation":[{"name":"Department of Zoology , Faculty of Science, , Egypt"},{"name":"Menoufia University , Faculty of Science, , Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eman H","family":"Kandil","sequence":"additional","affiliation":[{"name":"Department of Zoology , Faculty of Science, , Egypt"},{"name":"Menoufia University , Faculty of Science, , Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,12,1]]},"reference":[{"issue":"1","key":"2023122114493914800_ref1","first-page":"153","article-title":"Carbendazim induced histopathological changes in testis and epididymis and some enzymes activities in testis of Rattus rattus","volume":"12","author":"Gawande","year":"2009","journal-title":"J Exp Zool"},{"issue":"3","key":"2023122114493914800_ref2","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.yrtph.2014.05.016","article-title":"Reproductive and possible hormonal effects of carbendazim","volume":"69","author":"Rama","year":"2014","journal-title":"Regul Toxicol Pharmacol"},{"key":"2023122114493914800_ref3","doi-asserted-by":"crossref","first-page":"135231","DOI":"10.1016\/j.chemosphere.2022.135231","article-title":"Effectiveness, and mechanisms of the adsorption of carbendazim from wastewater onto commercial activated carbon","volume":"304","author":"Li","year":"2022","journal-title":"Chemosphere"},{"volume-title":"WHO environmental health criteria 148: Benomyl","year":"1993","key":"2023122114493914800_ref4"},{"issue":"12","key":"2023122114493914800_ref5","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1191\/096032701718890603","article-title":"Carbendazim-induced haematological, biochemical and histopathological changes to the liver and kidney of male rats","volume":"20","author":"Selmano\u011flu","year":"2001","journal-title":"Hum Exp Toxicol"},{"issue":"4","key":"2023122114493914800_ref6","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1191\/0960327102ht187oa","article-title":"Effects of carbendazim on rat thyroid, parathyroid, pituitary and adrenal glands and their hormones","volume":"21","author":"Barlas","year":"2002","journal-title":"Hum Exp Toxicol"},{"issue":"3","key":"2023122114493914800_ref7","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/s10311-016-0566-2","article-title":"Toxicity, monitoring and biodegradation of the fungicide carbendazim","volume":"14","author":"Singh","year":"2016","journal-title":"Environ Chem Lett"},{"issue":"11","key":"2023122114493914800_ref8","doi-asserted-by":"crossref","first-page":"6384","DOI":"10.1016\/j.sjbs.2021.07.014","article-title":"New phthalimide analog ameliorates CCl4 induced hepatic injury in mice via reducing ROS formation, inflammation, and apoptosis","volume":"28","author":"El-Aarag","year":"2021","journal-title":"Saudi J Biol Sci"},{"key":"2023122114493914800_ref9","doi-asserted-by":"crossref","first-page":"708785","DOI":"10.3389\/fphar.2021.708785","article-title":"Therapeutic impact of costus (Saussurea lappa) against Ehrlich solid tumor-induced cardiac toxicity and DNA damage in female mice","volume":"12","author":"Elgharabawy","year":"2021","journal-title":"Front Pharmacol"},{"issue":"5","key":"2023122114493914800_ref10","doi-asserted-by":"crossref","first-page":"3871","DOI":"10.1016\/j.sjbs.2022.03.016","article-title":"Ellagic acid regulates hyperglycemic state through modulation of pancreatic IL-6 and TNF- \u03b1 immunoexpression","volume":"29","author":"Elbandrawy","year":"2022","journal-title":"Saudi J Biol Sci"},{"issue":"1","key":"2023122114493914800_ref11","doi-asserted-by":"crossref","DOI":"10.1590\/s2175-97902018000117261","article-title":"Star anise extracts modulation of reproductive parameters, fertility potential and DNA fragmentation induced by growth promoter Equigan in rat testes","volume":"54","author":"Elmasry","year":"2018","journal-title":"Braz J Pharm Sci"},{"issue":"9","key":"2023122114493914800_ref12","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1002\/tox.22931","article-title":"Therapeutic effects of rocket seeds (Eruca sativa L.) against testicular toxicity and oxidative stress caused by silver nanoparticles injection in rats","volume":"35","author":"Altwaijry","year":"2020","journal-title":"Environ Toxicol"},{"key":"2023122114493914800_ref13","doi-asserted-by":"crossref","first-page":"110819","DOI":"10.1016\/j.biopha.2020.110819","article-title":"Evaluation of the testicular protection conferred by damiana (Turnera diffusa Willd.) against amitriptyline-induced testicular toxicity, DNA damage and apoptosis in rats","volume":"132","author":"Tousson","year":"2020","journal-title":"Biomed Pharmacother"},{"issue":"5","key":"2023122114493914800_ref14","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1177\/0748233712472523","article-title":"Protective role of L-carnitine and vitamin E on the testis of atherosclerotic rats","volume":"31","author":"Salama","year":"2015","journal-title":"Toxicol Ind Health"},{"issue":"17","key":"2023122114493914800_ref15","doi-asserted-by":"crossref","first-page":"17246","DOI":"10.1007\/s11356-016-6876-x","article-title":"Beneficial role of ascorbic and folic acids antioxidants against thyroxin-induced testicular dysfunction in hyperthyroid rats","volume":"23","author":"Beltagy","year":"2016","journal-title":"Environ Sci Pollut Res"},{"key":"2023122114493914800_ref16","doi-asserted-by":"crossref","first-page":"108908","DOI":"10.1016\/j.biopha.2019.108908","article-title":"Grape seeds proanthocyanidin extract ameliorates Ehrlich solid tumor induced renal tissue and DNA damage in mice","volume":"115","author":"Abd Eldaim","year":"2019","journal-title":"Biomed Pharmacother"},{"issue":"2","key":"2023122114493914800_ref17","doi-asserted-by":"crossref","first-page":"193","DOI":"10.3844\/ojbsci.2023.193.201","article-title":"Impact of coriander seeds extract against thyroidectomy induced testicular damage and DNA replication in male rats","volume":"23","author":"Alankooshi","year":"2023","journal-title":"OnLine J Biol Sci"},{"issue":"2","key":"2023122114493914800_ref18","doi-asserted-by":"crossref","first-page":"487","DOI":"10.3390\/molecules26020487","article-title":"Antioxidant, anti-inflammatory and antidiabetic proprieties of LC-MS\/MS identified polyphenols from coriander seeds","volume":"26","author":"Mechchate","year":"2021","journal-title":"Molecules"},{"issue":"7","key":"2023122114493914800_ref19","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1177\/0748233712462470","article-title":"Effect of coriander on thioacetamide-induced hepatotoxicity in rats","volume":"30","author":"Moustafa","year":"2014","journal-title":"Toxicol Ind Health"},{"issue":"7","key":"2023122114493914800_ref20","doi-asserted-by":"crossref","first-page":"17374","DOI":"10.1007\/s11356-022-23312-1","article-title":"Ameliorative role of chitosan nanoparticles against silver nanoparticle-induced reproductive toxicity in male albino rats","volume":"30","author":"Mahgoob","year":"2023","journal-title":"Environ Sci Pollut Res"},{"issue":"2","key":"2023122114493914800_ref21","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1172\/JCI105527","article-title":"Radioimmunoassay for luteinizing hormone in human plasma or serum: physiological studies","volume":"46","author":"Odell","year":"1981","journal-title":"J Clin Invest"},{"issue":"5","key":"2023122114493914800_ref22","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1210\/endo-95-5-1380","article-title":"The effect of sexual maturation of testicular sensitivity to LH stimulation of testosterone secretion in the intact rat","volume":"95","author":"Odell","year":"1974","journal-title":"Endocrinology"},{"issue":"1","key":"2023122114493914800_ref23","first-page":"59","article-title":"Protective effect of flavonides against the toxicity of vinblastine cyclophosphamide and paracetamol by inhibition of lipid\u2013peroxydation and increase of liver glutathione","volume":"7","author":"Mesbah","year":"2004","journal-title":"Haematol"},{"key":"2023122114493914800_ref24","doi-asserted-by":"crossref","first-page":"5162687","DOI":"10.1155\/2019\/5162687","article-title":"Antineoplastic activity and curative role of Avenanthramides against the growth of Ehrlich solid Tumors in mice","volume":"2019","author":"Aldubayan","year":"2019","journal-title":"Oxidative Med Cell Longev"},{"key":"2023122114493914800_ref25","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.fct.2014.06.029","article-title":"Ameliorating effect of chicory (Chichorium intybus L.) fruit extract against 4-tert-octylphenol induced liver injury and oxidative stress in male rats","volume":"72","author":"Saggu","year":"2014","journal-title":"Food Chem Toxicol"},{"issue":"6","key":"2023122114493914800_ref26","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/S1357-2725(96)00167-7","article-title":"Nitric oxide","volume":"29","author":"Robbins","year":"1997","journal-title":"Int J Biochem Cell Biol"},{"issue":"3","key":"2023122114493914800_ref27","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1177\/1933719111418126","article-title":"Histopathological and immunohistochemical changes in the testes of rabbits after injection with the growth promoter boldenone","volume":"19","author":"Tousson","year":"2012","journal-title":"Reprod Sci"},{"issue":"5","key":"2023122114493914800_ref28","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1080\/01926230701481931","article-title":"Dose-dependent effects of Sertoli cell toxicants 2,5-Hexanedione, carbendazim, and mono-(2-ethylhexyl) phthalate in adult rat testis","volume":"35","author":"Moffit","year":"2007","journal-title":"Toxicol Pathol"},{"issue":"11","key":"2023122114493914800_ref29","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1007\/s00204-007-0204-7","article-title":"Protective effect of vitamin E against carbendazim-induced testicular toxicity-histopathological evidences and reduced residue levels in testis and serum","volume":"81","author":"Rajeswary","year":"2007","journal-title":"Arch Toxicol"},{"key":"2023122114493914800_ref30","doi-asserted-by":"crossref","first-page":"102127","DOI":"10.1016\/j.tice.2023.102127","article-title":"Modulatory role of Coriandrum sativum (coriander) extract against diabetic complications on the gonads of female rats and their offspring","volume":"83","author":"Attaallah","year":"2023","journal-title":"Tissue Cell"},{"issue":"4","key":"2023122114493914800_ref31","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/S0040-8166(97)80033-X","article-title":"Further observations on carbendazim-induced abnormalities of spermatid morphology in rats","volume":"29","author":"Nakai","year":"1997","journal-title":"Tissue Cell"},{"issue":"2","key":"2023122114493914800_ref32","first-page":"208","article-title":"The protective effect of linseed oil against bcarbendazim induced testicular toxicity in rats","volume":"49","author":"Metwally","year":"2011","journal-title":"Eur J Sci Res"},{"issue":"20","key":"2023122114493914800_ref33","doi-asserted-by":"crossref","first-page":"24799","DOI":"10.1007\/s11356-020-09045-z","article-title":"Oxidative stress and mitochondrial dysfunction in organophosphate pesticide-induced neurotoxicity and its amelioration: a review","volume":"27","author":"Farkhondeh","year":"2020","journal-title":"Environ Sci Pollut Res"},{"issue":"10","key":"2023122114493914800_ref34","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1002\/tox.23606","article-title":"The potential curative role of Avena sativa extract against oxidative stress, DNA damage and apoptosis induced by acute hepatotoxicity of silver nanoparticles in rats","volume":"37","author":"Tousson","year":"2022","journal-title":"Environ Toxicol"},{"issue":"1","key":"2023122114493914800_ref35","doi-asserted-by":"crossref","first-page":"441","DOI":"10.13005\/bpj\/2625","article-title":"Curcumin alleviates thioacetamide-induced kidney toxicity in rats: enhancing antioxidant system, and attenuating oxidative stress, DNA damage, and inflammation","volume":"16","author":"Radwan","year":"2023","journal-title":"Biomed Pharmacol J"},{"key":"2023122114493914800_ref36","first-page":"108758","article-title":"Mediation of oxidative stress toxicity induced by pyrethroid pesticides in fish","volume":"234","author":"Yang","year":"2020","journal-title":"Comp Biochem Physiol C: Toxicol Pharmacol"},{"key":"2023122114493914800_ref37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2022\/5563759","article-title":"A common feature of pesticides: oxidative stress\u2014the role of oxidative stress in pesticide-induced toxicity","volume":"2022","author":"Sule","year":"2022","journal-title":"Oxidative Med Cell Longev"},{"issue":"15","key":"2023122114493914800_ref38","doi-asserted-by":"crossref","first-page":"45046","DOI":"10.1007\/s11356-023-25304-1","article-title":"Organochlorine pesticides induce thyroid tumors through oxidative stress; an in vivo and in silico study","volume":"30","author":"Salimi","year":"2023","journal-title":"Environ Sci Pollut Res"},{"issue":"1","key":"2023122114493914800_ref39","first-page":"9","article-title":"Amelioration of carbendaziminduced testicular dysfunction by vitamin E and pumpkin seed oil in rats","volume":"31","author":"Hamdy","year":"2010","journal-title":"J Drug Res"},{"issue":"3","key":"2023122114493914800_ref40","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1177\/0748233712456059","article-title":"Carbendazim-induced testicular damage and oxidative stress in albino rats: ameliorative effect of licorice aqueous extract","volume":"30","author":"Sakr","year":"2014","journal-title":"Toxicol Ind Health"},{"key":"2023122114493914800_ref41","doi-asserted-by":"crossref","first-page":"152808","DOI":"10.1016\/j.tox.2021.152808","article-title":"L-carnitine extenuates endocrine disruption, inflammatory burst and oxidative stress in carbendazim-challenged male rats via upregulation of testicular StAR and FABP9, and downregulation of P38-MAPK pathways","volume":"457","author":"Salem","year":"2021","journal-title":"Toxicology"},{"issue":"7","key":"2023122114493914800_ref42","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1292\/jvms.61.755","article-title":"Testicular damage after exposure to carbendazim depends on the number of patent efferent ductules","volume":"61","author":"Gotoh","year":"1999","journal-title":"J Vet Med Sci"},{"issue":"3","key":"2023122114493914800_ref43","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s12011-009-8553-0","article-title":"Prophylactic efficacy of Coriandrum sativum (coriander) on testis of lead-exposed mice","volume":"136","author":"Sharma","year":"2010","journal-title":"Biol Trace Elem Res"},{"issue":"1","key":"2023122114493914800_ref44","first-page":"31","article-title":"Prophylactic effects of vitamin E and coriander (Coriandrum sativum) extract on lead-induced testicular damage in Swiss albino mice","volume":"2","author":"Islam","year":"2019","journal-title":"J Adv Biotechnol Exp Ther"},{"key":"2023122114493914800_ref45","first-page":"344","article-title":"The inhibitory effect of aqueous extract of coriander (Coriandrum sativum L.) leaves on the activity of male reproductive system of albino mice","volume":"57","author":"Al-Rubaye","year":"2016","journal-title":"Iraqi J Sci"}],"container-title":["Toxicology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/toxres\/article-pdf\/12\/6\/1152\/54545358\/tfad109.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/toxres\/article-pdf\/12\/6\/1152\/54545358\/tfad109.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T14:50:26Z","timestamp":1703170226000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/toxres\/article\/12\/6\/1152\/7457336"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,1]]},"references-count":45,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2023,12,1]]},"published-print":{"date-parts":[[2023,12,17]]}},"URL":"https:\/\/doi.org\/10.1093\/toxres\/tfad109","relation":{},"ISSN":["2045-4538"],"issn-type":[{"type":"electronic","value":"2045-4538"}],"subject":[],"published-other":{"date-parts":[[2023,12]]},"published":{"date-parts":[[2023,12,1]]}}}