{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T02:40:23Z","timestamp":1788835223237,"version":"build-2803163510"},"reference-count":57,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,12,30]],"date-time":"2023-12-30T00:00:00Z","timestamp":1703894400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Scientific Research Projects Coordination Unit of Usak University","award":["BABK\/2017\/SB001"],"award-info":[{"award-number":["BABK\/2017\/SB001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>It is seen that cyclophosphamide, which is used in treating many diseases, especially cancer, causes toxicity in studies, and its metabolites induce oxidative stress. This study aimed to investigate the protective effects of resveratrol and Coenzyme Q10, known for their antioxidant properties, separately and together, against oxidative stress induced by cyclophosphamide. In this study, 35 Wistar albino male rats were divided into five groups. Groups; Control group, cyclophosphamide (CP) group (CP as 75\u00a0mg\u00a0kg\u00a0i.p. on day 14), coenzyme Q10 (CoQ10)\u00a0+\u00a0CP group (20\u00a0mg\/kg\u00a0i.p. CoQ10\u00a0+\u00a075\u00a0mg\u00a0kg\u00a0i.p. CP), resveratrol (Res)\u00a0+\u00a0CP group (20\u00a0mg\/kg\u00a0i.p. Res\u00a0+\u00a075\u00a0mg\/kg\u00a0i.p. CP), CoQ10\u00a0+\u00a0Res\u00a0+\u00a0CP group (20\u00a0mg\/kg i.p Res\u00a0+\u00a020\u00a0mg\/kg i.p CoQ10 and 75\u00a0mg\/kg i.p.CP). At the end of the experiment, the cholesterol, creatinine and urea levels of the group given CP increased, while a decrease was observed in the groups given Res and CoQ10. Malondialdehyde level was high, glutathione level, superoxide dismutase and catalase activities were decreased in the blood and all tissues (liver, kidney, brain, heart and testis) of the CP given group. DNA damage and histopathological changes were also observed. In contrast, Res and CoQ10, both separately and together, reversed the CP-induced altered level and enzyme activities and ameliorated DNA damage and histopathological changes. In this study, the effects of Res and CoQ10 against CP toxicity were examined both separately and together.<\/jats:p>","DOI":"10.1093\/toxres\/tfad123","type":"journal-article","created":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T06:25:30Z","timestamp":1704176730000},"source":"Crossref","is-referenced-by-count":13,"title":["Investigation of protective effect of resveratrol and coenzyme Q10 against cyclophosphamide-induced lipid peroxidation, oxidative stress and DNA damage in rats"],"prefix":"10.1093","volume":"13","author":[{"given":"Erten","family":"Akbel","sequence":"first","affiliation":[{"name":"Usak Health Training School, Usak University , 64200, U\u015fak , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0198-629X","authenticated-orcid":false,"given":"Ismail","family":"Kucukkurt","sequence":"additional","affiliation":[{"name":"Department of Biochemistry , Faculty of Veterinary Medicine, , 03200, Afyonkarahisar , Turkey"},{"name":"Afyon Kocatepe University , Faculty of Veterinary Medicine, , 03200, Afyonkarahisar , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sinan","family":"Ince","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology , Faculty of Veterinary Medicine, , 03200, Afyonkarahisar , Turkey"},{"name":"Afyon Kocatepe University , Faculty of Veterinary Medicine, , 03200, Afyonkarahisar , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasan Huseyin","family":"Demirel","sequence":"additional","affiliation":[{"name":"Bayat Vocational School, Afyon Kocatepe University , 03780, Afyonkarahisar , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damla Arslan","family":"Acaroz","sequence":"additional","affiliation":[{"name":"Department of Biochemistry , Faculty of Veterinary Medicine, , 03200, Afyonkarahisar , Turkey"},{"name":"Afyon Kocatepe University , Faculty of Veterinary Medicine, 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