{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T23:48:55Z","timestamp":1792540135510,"version":"4.5.0"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100003970","name":"Isfahan University of Medical Sciences","doi-asserted-by":"publisher","award":["3400606"],"award-info":[{"award-number":["3400606"]}],"id":[{"id":"10.13039\/501100003970","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Acetamiprid (ACE), is a popular neonicotinoid pesticide, that has a high affinity for mammalian nicotinic acetylcholine receptors (nAChRs). Therefore, ACE might induce depressive effects by perturbing the cholinergic system in mammalian. The aim of this study was to evaluate the effects of ACE exposure on depressive-like behaviors and grip strength (GS) in mice. Also the possible role of nAChR activation in depression was assessed by varenicline, and bupropion. Male Swiss mice (27\u00a0\u00b1\u00a02\u00a0g) were daily exposed to ACE by gavage (0.1, 1, 5\u00a0mg\/kg), behavioral tests took place after 3\u00a0h, 7\u00a0days and 15\u00a0days, the subacute ACE (0.1\u00a0mg\/kg) exposure was assessed after 30\u00a0days. Varenicline (0.5\u00a0mg\/kg) or bupropion (4\u00a0mg\/kg) were injected intraperitoneally 30\u00a0min prior exposure to (1\u00a0mg\/kg) ACE. The locomotor activity, forced swimming test (FST), and sucrose preference (SP) test were assessed. After a week ACE dose dependently increased the immobility time during FST, and after 15\u00a0days\u2019 depressive behavior was observed equally for ACE (0.1\u20135\u00a0mg\/kg). The subacute exposure (0.1\u00a0mg\/kg) significantly increased the immobility time, SP also declined that revealed anhedonia. These behavioral changes showed that ACE can initiate depressive effects. The changes in locomotor activity were not significant. GS significantly reduced following a week of exposure to ACE (1\u20135\u00a0mg\/kg) that indicated neurotoxicity. These effects were antagonized by bupropion or varenicline, thus ACE effect on nAChRs was essential in initiating the depressive behavior.<\/jats:p>\n                  <jats:p>Highlights ACE induced depressive behavior in mice dose dependently ACE exposure reduced mice grip strength ACE neurotoxicity was reversed by bupropion or varenicline nAChRs over activity is involved in ACE neurotoxicity in mice<\/jats:p>","DOI":"10.1093\/toxres\/tfad126","type":"journal-article","created":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T10:35:39Z","timestamp":1703241339000},"source":"Crossref","is-referenced-by-count":4,"title":["Bupropion and varenicline administration reversed depressive behavior induced by acetamiprid exposure in mice: the role of nAChRs in depression"],"prefix":"10.1093","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3150-5581","authenticated-orcid":false,"given":"Azadeh","family":"Mesripour","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology , School of Pharmacy and Pharmaceutical Sciences, , Hezarjerib boulevard, Isfahan 81746-73461 , Iran"},{"name":"Isfahan University of Medical Sciences , School of Pharmacy and Pharmaceutical Sciences, , Hezarjerib boulevard, Isfahan 81746-73461 , Iran"},{"name":"Isfahan Pharmaceutical Sciences Research Center, Isfahan University of Medical Sciences , Hezarjerib boulevard, Isfahan 81746-73461 , Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2551-5163","authenticated-orcid":false,"given":"Leila","family":"Soltani","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology , School of Pharmacy and Pharmaceutical Sciences, , Hezarjerib boulevard, Isfahan 81746-73461 , Iran"},{"name":"Isfahan University of Medical Sciences , School of Pharmacy and Pharmaceutical Sciences, , Hezarjerib boulevard, Isfahan 81746-73461 , Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3416-2596","authenticated-orcid":false,"given":"Mehdi","family":"Aliomrani","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology , School of Pharmacy and Pharmaceutical Sciences, , Hezarjerib boulevard, Isfahan 81746-73461 , Iran"},{"name":"Isfahan University of Medical Sciences , School of Pharmacy and Pharmaceutical Sciences, , Hezarjerib boulevard, Isfahan 81746-73461 , Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,1,16]]},"reference":[{"issue":"11","key":"2024011717150692800_ref1","doi-asserted-by":"crossref","first-page":"2340","DOI":"10.1016\/S2095-3119(15)61126-1","article-title":"Agricultural pesticide use and food safety: California\u2019s model","volume":"14","author":"Zhang","year":"2015","journal-title":"J Integr 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