{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:58:14Z","timestamp":1760162294416,"version":"3.41.2"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Acute antipsychotic poisoning is correlated to a high prevalence of qt interval prolongation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Aim<\/jats:title>\n                  <jats:p>This study aimed to evaluate early qt interval prolongation predictors in acute antipsychotic-poisoned patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methodology<\/jats:title>\n                  <jats:p>This prospective cohort study enrolled 70 symptomatic patients with acute antipsychotic poisoning. Sociodemographic data, toxicological, clinical, investigation, and outcomes were collected and analyzed. The estimation of the corrected qt interval (QTc) was performed using Bazett\u2019s method. Primary outcome was normal or abnormal length of QTc interval. Secondary outcomes included duration of hospital stay, complete recovery and mortality. The corrected qt interval was analyzed by univariate and multivariate logistic regression analysis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Patients were divided into groups A (normal QTc interval up to 440\u00a0msec; 58.6% of cases) and B (prolonged QTc interval\u00a0\u2265\u00a0440\u00a0msec; 41.4% of cases). Patients in group B had significantly high incidences of quetiapine intake, bradycardia, hypotension, hypokalemia, and long duration of hospital stay. By multivariate analysis, quetiapine [Odd\u2019s ratio (OR): 39.674; Confidence Interval (C.I:3.426\u2013459.476)], bradycardia [OR: 22.664; C.I (2.534\u2013202.690)], and hypotension [OR: 16.263; (C.I: 2.168\u2013122.009)] were significantly correlated with prolonged QTc interval.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>In acute antipsychotic poisoning, quetiapine, bradycardia, and hypotension are early clinical predictors for prolonged QTc interval.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/toxres\/tfae038","type":"journal-article","created":{"date-parts":[[2024,3,17]],"date-time":"2024-03-17T06:53:38Z","timestamp":1710658418000},"source":"Crossref","is-referenced-by-count":2,"title":["Predictors for prolonged qt intervals in acute antipsychotic poisoned patients"],"prefix":"10.1093","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6953-1577","authenticated-orcid":false,"given":"Heba K","family":"Khalifa","sequence":"first","affiliation":[{"name":"Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine , Medical collages campus, 6 th Floor, Al-Geish Street, Tanta University, Tanta, Elgharbya, 31527, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0153-2119","authenticated-orcid":false,"given":"Nouran","family":"Mostafa Mansour","sequence":"additional","affiliation":[{"name":"Cardiology Department, Faculty of Medicine, Medical collages campus, Al-Geish Street, Tanta University , Tanta, Elgharbya, 31527, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4273-8030","authenticated-orcid":false,"given":"Alshaimma","family":"Elmansy","sequence":"additional","affiliation":[{"name":"Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine , Medical collages campus, 6 th Floor, Al-Geish Street, Tanta University, Tanta, Elgharbya, 31527, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,3,15]]},"reference":[{"issue":"1","key":"2024031706505568500_ref1","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1186\/s12888-018-1993-3","article-title":"Relative toxicity of mood stabilisers and antipsychotics: case fatality and fatal toxicity associated with self-poisoning","volume":"18","author":"Ferrey","year":"2018","journal-title":"BMC Psychiatry"},{"issue":"4","key":"2024031706505568500_ref2","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.cpem.2012.09.005","article-title":"Adverse effects and toxicity of the atypical antipsychotics: what is important for the pediatric emergency medicine practitioner","volume":"13","author":"Rasimas","year":"2012","journal-title":"Clin Pediatr Emerg 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