{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T02:21:57Z","timestamp":1790130117879,"version":"4.0.1"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31972942"],"award-info":[{"award-number":["31972942"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Lead (Pb) is a nonessential heavy metal, which can cause many health problems. Isochlorogenic acid A (ICAA), a phenolic acid present in tea, fruits, vegetables, coffee, plant-based food products, and various medicinal plants, exerts multiple effects, including anti-oxidant, antiviral, anti-inflammatory and antifibrotic functions. Thus, the purpose of our study was to determine if ICAA could prevent Pb-induced hepatotoxicity in ICR mice. An evaluation was performed on oxidative stress, inflammation and fibrosis, and related signaling. The results indicate that ICAA attenuates Pb-induced abnormal liver function. ICAA reduced liver fibrosis, inflammation and oxidative stress caused by Pb. ICAA abated Pb-induced fibrosis and decreased inflammatory cytokines interleukin-1\u03b2 (IL-1\u03b2) and tumor necrosis factor-alpha (TNF-\u03b1). ICAA abrogated reductions in activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx). Masson staining revealed that ICAA reduced collagen fiber deposition in Pb-induced fibrotic livers. Western blot and immunohistochemistry analyses showed ICAA increased phosphorylated AMP-activated protein kinase (p-AMPK) expression. ICAA also reduced the expression of collagen I, \u03b1-smooth muscle actin (\u03b1-SMA), phosphorylated extracellular signal-regulated kinase (p-ERK), phosphorylated c-jun N-terminal kinase (p-JNK), p-p38, phosphorylated signal transducer and phosphorylated activator of transcription 3 (p-STAT3), transforming growth factor \u03b21 (TGF-\u03b21), and p-Smad2\/3 in livers of mice. Overall, ICAA ameliorates Pb-induced hepatitis and fibrosis by inhibiting the AMPK\/MAPKs\/NF-\u03baB and STAT3\/TGF-\u03b21\/Smad2\/3 pathways.<\/jats:p>","DOI":"10.1093\/toxres\/tfae072","type":"journal-article","created":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T23:58:32Z","timestamp":1714694312000},"source":"Crossref","is-referenced-by-count":13,"title":["Lead-induced liver fibrosis and inflammation in mice by the AMPK\/MAPKs\/NF-\u03baB and STAT3\/TGF-\u03b21\/Smad2\/3 pathways: the role of Isochlorogenic acid a"],"prefix":"10.1093","volume":"13","author":[{"given":"Jun-Tao","family":"Guo","sequence":"first","affiliation":[{"name":"School of Life Science, Jiangsu Normal University , No. 101, Shanghai Road, Tongshan New Area, 221116, Xuzhou City, Jiangsu Province , PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han-Yu","family":"Li","sequence":"additional","affiliation":[{"name":"School of Life Science, Jiangsu Normal University , No. 101, Shanghai Road, Tongshan New Area, 221116, Xuzhou City, Jiangsu Province , PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Cheng","sequence":"additional","affiliation":[{"name":"School of Life Science, Jiangsu Normal University , No. 101, Shanghai Road, Tongshan New Area, 221116, Xuzhou City, Jiangsu Province , PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Xue","family":"Shi","sequence":"additional","affiliation":[{"name":"School of Life Science, Jiangsu Normal University , No. 101, Shanghai Road, Tongshan New Area, 221116, Xuzhou City, Jiangsu Province , PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Nan","family":"Ruan","sequence":"additional","affiliation":[{"name":"School of Life Science, Jiangsu Normal University , No. 101, Shanghai Road, Tongshan New Area, 221116, Xuzhou City, Jiangsu Province , PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Li","sequence":"additional","affiliation":[{"name":"School of Life Science, Jiangsu Normal University , No. 101, Shanghai Road, Tongshan New Area, 221116, Xuzhou City, Jiangsu Province , PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7343-3884","authenticated-orcid":false,"given":"Chan-Min","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Life Science, Jiangsu Normal University , No. 101, Shanghai Road, Tongshan New Area, 221116, Xuzhou City, Jiangsu Province , PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,5,9]]},"reference":[{"issue":"11","key":"2024050915191099500_ref1","first-page":"703","article-title":"Curcumin ameliorates lead-induced hepatotoxicity by suppressing oxidative stress and inflammation, and modulating Akt\/GSK-3\u03b2 signaling 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