{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:34:50Z","timestamp":1787009690159,"version":"build-2736575974"},"reference-count":125,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Toxic agents can adversely impact the male reproductive system mainly via activating oxidative stress affecting the seminiferous epithelia, spermatogenesis, sperms, and the testis. Toxic agents lead to the excessive generation of reactive oxygen species (ROS), such as hydroxyl radicals, hydrogen peroxide, and superoxide anions. ROS exert a cytotoxic effect and oxidative damage to nucleic acids, proteins, and membrane lipids. Hesperidin is a pharmacologically active phytoflavone abundantly occurring in citrus fruits, such as oranges and lemons. It has shown various pharmacological properties such as antioxidant, anti-inflammatory, anti-carcinogenic, analgesic, antiviral, anti-coagulant, hypolipidemic, and hypoglycemic effects. Hesperidin has been found to exert protective effects against natural and chemical toxins-induced organ toxicity. Considerable evidence has implicated the testicular protective effects of hesperidin against the toxicological properties of pharmaceutical drugs as well as biological and chemical agents, and in the present review, we discussed, for the first time, the reported studies. The resultant data indicate that hesperidin can exert testicular protective effects through antioxidant properties.<\/jats:p>","DOI":"10.1093\/toxres\/tfae078","type":"journal-article","created":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T00:26:00Z","timestamp":1715905560000},"source":"Crossref","is-referenced-by-count":6,"title":["Testicular protective effects of hesperidin against chemical and biological toxicants"],"prefix":"10.1093","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9527-1687","authenticated-orcid":false,"given":"Linyin","family":"Yan","sequence":"first","affiliation":[{"name":"Hainan Vocational University of Science and Technology , No. 18, Qiongshan Avenue, Meilan District, Haikou City, Hainan 570100 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Orthopedic Biomedical and Device Innovation , School of Health Science and Engineering, , 516 Jungong Rd., Shanghai 200093 , China"},{"name":"University of Shanghai for Science and Technology , School of Health Science and Engineering, , 516 Jungong Rd., Shanghai 200093 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Decai","family":"Dai","sequence":"additional","affiliation":[{"name":"Hainan Vocational University of Science and Technology , No. 18, Qiongshan Avenue, Meilan District, Haikou City, Hainan 570100 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Hainan Vocational University of Science and Technology , No. 18, Qiongshan Avenue, Meilan District, Haikou City, Hainan 570100 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanqiang","family":"Li","sequence":"additional","affiliation":[{"name":"Hainan Vocational University of Science and Technology , No. 18, Qiongshan Avenue, Meilan District, Haikou City, Hainan 570100 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Xiao","sequence":"additional","affiliation":[{"name":"Wuhan Aimin Pharmaceutical Co., LTD , No. 10, Entrepreneurship Avenue, Gedian Economic and Technological Development Zone, Ezhou City, Wuhan, Hubei , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,5,23]]},"reference":[{"issue":"1","key":"2024052405441316900_ref1","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s40360-023-00709-3","article-title":"Determination of biochemical and histopathological changes on testicular and epididymis tissues induced by exposure to insecticide Imidacloprid during postnatal development in rats","volume":"24","author":"Sardar","year":"2023","journal-title":"BMC Pharmacol Toxicol"},{"issue":"4","key":"2024052405441316900_ref2","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1007\/s12011-022-03280-w","article-title":"Silica nanoparticle\u2013induced reproductive toxicity in male albino rats via testicular apoptosis and oxidative stress","volume":"201","author":"Azouz","year":"2023","journal-title":"Biol Trace Elem Res"},{"issue":"05","key":"2024052405441316900_ref3","doi-asserted-by":"crossref","first-page":"60","DOI":"10.36348\/sijb.2023.v06i05.002","article-title":"Hydroethanolic leaf extract of Erythrina Senegalensis attenuates diclofenac sodium-induced testicular and Epididymal perturbation in male Wistar rats","volume":"6","author":"Ezihe","year":"2023","journal-title":"Sch Int J Biochem"},{"key":"2024052405441316900_ref4","first-page":"527","article-title":"Comparison of reproductive hormone levels in male and female camels (Camelus dromedarius) during rutting and non-rutting seasons and their relation with some minerals and antioxidant status","volume":"20","author":"Sami","year":"2022","journal-title":"Caspian J Environ Sci"},{"issue":"2","key":"2024052405441316900_ref5","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s11259-022-10022-9","article-title":"An updated insight on testicular hemodynamics: environmental, physiological, and technical perspectives in farm and companion animals","volume":"47","author":"Samir","year":"2023","journal-title":"Vet Res Commun"},{"issue":"2","key":"2024052405441316900_ref6","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1152\/physrev.1982.62.2.624","article-title":"Physiological significance of fluid secretion in the testis and blood-testis barrier","volume":"62","author":"Waites","year":"1982","journal-title":"Physiol Rev"},{"key":"2024052405441316900_ref7","doi-asserted-by":"crossref","DOI":"10.1530\/endoabs.90.OC5.2","volume-title":"The association between hormonal control during infancy and testicular adrenal rest tumor development in males with congenital adrenal hyperplasia","author":"Schroder","year":"2023"},{"key":"2024052405441316900_ref8","first-page":"830","volume-title":"Handbook of Toxicologic pathology; 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