{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T19:39:20Z","timestamp":1793907560418,"version":"4.8.0"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"4","funder":[{"name":"Afyon Kocatepe University Scientific Research Council of Turkey"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>In the present study, we investigated the protective effect of magnolin (MAG) against oxidative stress induced by cyclophosphamide (CP) and its role in the Nrf2\/HO-1 signaling pathway. Rats were administered MAG (1\u00a0mg\/kg, i.p.) for 14\u00a0days and CP (75\u00a0mg\/kg, i.p.) on the 14th day. CP administration increased tissue damage, as evidenced by elevated levels of transaminases (aspartate and alanine), alkaline phosphatase, and renal parameters (blood urea nitrogen and creatinine). Additionally, 8-hydroxy-2\u2032-deoxyguanosine and malondialdehyde levels were increased, whereas glutathione levels, along with catalase and superoxide dismutase activities, decreased in CP-treated rats. CP also down-regulated the expression of Bcl-2, HO-1, Nrf2, and NQO-1, while up-regulating Bax, Cas-3, TNF-\u03b1, Cox-2, iNOS, IL-6, IL-1\u03b2, and NF\u03baB in liver and kidney tissues. In addition, CP treatment caused histopathological changes in heart, lung, liver, kidney, brain, and testis tissues. Treatment with MAG improved biochemical and oxidative stress parameters and prevented histopathological changes in CP-treated rats. Moreover, MAG suppressed the expression of inflammatory cytokines and apoptosis markers. In conclusion, MAG effectively prevented CP-induced toxicity by reducing oxidative stress, inflammation, and apoptosis, with its protective efficacy associated with the up-regulation of Nrf2\/HO-1 signaling.<\/jats:p>","DOI":"10.1093\/toxres\/tfae129","type":"journal-article","created":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T19:32:20Z","timestamp":1723145540000},"source":"Crossref","is-referenced-by-count":28,"title":["Magnolin alleviates cyclophosphamide-induced oxidative stress, inflammation, and apoptosis via\n                    <i>Nrf2\/HO-1<\/i>\n                    signaling pathway"],"prefix":"10.1093","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1915-9797","authenticated-orcid":false,"given":"Sinan","family":"Ince","sequence":"first","affiliation":[{"name":"Faculty of Veterinary Medicine , Department of Pharmacology and Toxicology, , 03200 Afyonkarahisar , Turkey"},{"name":"Afyon Kocatepe University , Department of Pharmacology and Toxicology, , 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