{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T06:38:45Z","timestamp":1775198325125,"version":"3.50.1"},"reference-count":116,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T00:00:00Z","timestamp":1725235200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100004320","name":"Shiraz University of Medical Sciences","doi-asserted-by":"publisher","award":["98-01-05-19487"],"award-info":[{"award-number":["98-01-05-19487"]}],"id":[{"id":"10.13039\/501100004320","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>The number of new diagnosed cancer cases and cancer deaths are increasing worldwide. Perfluorinated compounds (PFCs) are synthetic chemicals, which are possible inducers of cancer in human and laboratory animals. Studies showed that PFCs induce breast, prostate, kidney, liver and pancreas cancer by inducing genes being involved in carcinogenic pathways.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methodology<\/jats:title>\n                  <jats:p>This study reviews the association between PFCs induced up-regulation\/down-regulation of genes and signaling pathways that are important in promoting different types of cancer. To obtain chemical-gene interactions, an advanced search was performed in the Comparative Toxicogenomics Database platform.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Five most prevalent cancers were studied and the maps of their signaling pathways were drawn, and colored borders indicate significantly differentially expressed genes if there had been reports of alterations in expression in the presence of PFCs.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>In general, PFCs are capable of inducing cancer in human via altering PPAR\u03b1 and PI3K pathways, evading apoptosis, inducing sustained angiogenesis, alterations in proliferation and blocking differentiation. However, more epidemiological data and mechanistic studies are needed to better understand the carcinogenic effects of PFCs in human.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/toxres\/tfae151","type":"journal-article","created":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T07:54:28Z","timestamp":1727164468000},"source":"Crossref","is-referenced-by-count":4,"title":["A toxicogenomics-based identification of potential mechanisms and signaling pathways involved in PFCs-induced cancer in human"],"prefix":"10.1093","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8833-662X","authenticated-orcid":false,"given":"Zahra","family":"Dehghani","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology, School of Pharmacy, Shiraz University of Medical Sciences , Rokn Abad, Karafarin St., 7146864685, Shiraz, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7675-4146","authenticated-orcid":false,"given":"Sara","family":"Ranjbar","sequence":"additional","affiliation":[{"name":"Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences , Rokn Abad, Karafarin St., 7146864685, Shiraz, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0489-6433","authenticated-orcid":false,"given":"Farbod","family":"Shahabinezhad","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, School of Pharmacy, Shiraz University of Medical Sciences , Rokn Abad, Karafarin St., 7146864685, Shiraz, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8930-2708","authenticated-orcid":false,"given":"Pooria","family":"Sabouri","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, School of Pharmacy, Shiraz University of Medical Sciences , Rokn Abad, Karafarin St., 7146864685, Shiraz, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2203-6322","authenticated-orcid":false,"given":"Afshin Mohammadi","family":"Bardbori","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, School of Pharmacy, Shiraz University of Medical Sciences , Rokn Abad, Karafarin St., 7146864685, Shiraz, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,9,24]]},"reference":[{"issue":"3","key":"2024092407541518300_ref1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2020","journal-title":"CA Cancer J Clin"},{"issue":"1","key":"2024092407541518300_ref2","doi-asserted-by":"crossref","first-page":"54","DOI":"10.5306\/wjco.v7.i1.54","article-title":"Historical review of the causes of cancer","volume":"7","author":"Blackadar","year":"2016","journal-title":"World J Clin Oncol"},{"issue":"2","key":"2024092407541518300_ref3","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.mrgentox.2006.02.015","article-title":"Human cancer from environmental pollutants: the epidemiological evidence","volume":"608","author":"Boffetta","year":"2006","journal-title":"Mutat Res"},{"key":"2024092407541518300_ref4","volume-title":"Predictive biomarkers in oncology: applications in precision medicine","author":"Badve","year":"2018"},{"issue":"18","key":"2024092407541518300_ref5","doi-asserted-by":"crossref","first-page":"3864","DOI":"10.1021\/es991359u","article-title":"Perfluorinated surfactants and the environmental implications of their use in fire-fighting foams","volume":"34","author":"Moody","year":"2000","journal-title":"Environ Sci Technol"},{"issue":"4","key":"2024092407541518300_ref6","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1021\/es070895g","article-title":"Are PFCAs bioaccumulative? 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