{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T08:02:33Z","timestamp":1793347353745,"version":"4.5.0"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T00:00:00Z","timestamp":1725235200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"University Grant Commission"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Toxicological empirical research suggests that excessive utilization of paraquat, an herbicide, shows detrimental consequences on mammalian reproductive toxicity. The current study aims to study it as a reproductive toxin on the caprine testicular cells at 4- and 6-hour exposure duration. Paraquat treatment decreased the cell viability percentage and induced histological architectural alterations such as disruption of germinal epithelium, vacuolization, and pyknotic nuclei in the testis. The differential EB\/AO staining also revealed an increased incidence of apoptosis after paraquat treatment at both dosages, i.e. 10\u00a0mM and 100\u00a0mM. Paraquat also induces oxidative stress, as evident via increased Malondialdehyde levels (a byproduct of lipid peroxidation) and a decline in the antioxidant capacity (FRAP). However, co-administration of Vitamin E significantly reduced the paraquat-mediated decline in cell viability percentage, histological alterations, and apoptosis incidences and generated oxidative stress, indicating its antioxidative properties against paraquat exposure. This research concludes that Vitamin E co-administration considerably reduced the toxicity of paraquat elicited in testicles, suggesting that Vitamin E may have advantageous potential in preventing the male gonadotoxicity caused by paraquat use in agriculture.<\/jats:p>","DOI":"10.1093\/toxres\/tfae153","type":"journal-article","created":{"date-parts":[[2024,9,17]],"date-time":"2024-09-17T15:39:19Z","timestamp":1726587559000},"source":"Crossref","is-referenced-by-count":7,"title":["Effective attenuation of Paraquat induced oxidative stress and Genotoxicity in testicular germ cells by vitamin E in Caprines"],"prefix":"10.1093","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4333-6148","authenticated-orcid":false,"given":"Vishavjeet","family":"Rathee","sequence":"first","affiliation":[{"name":"Reproductive Physiology Laboratory , Department of Zoology, , Kurukshetra, Haryana 136119 India"},{"name":"Kurukshetra University , Department of Zoology, , Kurukshetra, Haryana 136119 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2859-7061","authenticated-orcid":false,"given":"Prerna","family":"Bikal","sequence":"additional","affiliation":[{"name":"Reproductive Physiology Laboratory , Department of Zoology, , Kurukshetra, Haryana 136119 India"},{"name":"Kurukshetra University , Department of Zoology, , Kurukshetra, Haryana 136119 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0095-8526","authenticated-orcid":false,"given":"Anshu","family":"Siwach","sequence":"additional","affiliation":[{"name":"Reproductive Physiology Laboratory , Department of Zoology, , Kurukshetra, Haryana 136119 India"},{"name":"Kurukshetra University , Department of Zoology, , Kurukshetra, Haryana 136119 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2183-3058","authenticated-orcid":false,"given":"Jitender Kumar","family":"Bhardwaj","sequence":"additional","affiliation":[{"name":"Reproductive Physiology Laboratory , Department of Zoology, , Kurukshetra, Haryana 136119 India"},{"name":"Kurukshetra University , Department of Zoology, , Kurukshetra, Haryana 136119 India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,9,24]]},"reference":[{"issue":"3","key":"2024092407533612200_ref1","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.3390\/ijerph18031112","article-title":"Agriculture development, pesticide application and its impact on the environment","volume":"18","author":"Tudi","year":"2021","journal-title":"Int J Environ Res Public Health"},{"issue":"3","key":"2024092407533612200_ref2","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.ejar.2020.08.007","article-title":"Pesticides pollution: classifications, human health impact, extraction and treatment techniques","volume":"46","author":"Hassaan","year":"2020","journal-title":"Egypt J Aquat Res"},{"issue":"11","key":"2024092407533612200_ref3","first-page":"1","article-title":"Worldwide pesticide usage and its impacts on ecosystem. 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