{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:34:39Z","timestamp":1787009679011,"version":"build-2736575974"},"reference-count":87,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T00:00:00Z","timestamp":1725235200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The tobacco epidemic signifies a major public health threat. Nicotine (NIC), a major active constituent in tobacco, impedes male fertility and semen quality. This work is implemented to explore the potential of selenium nanoparticles (SeNPs) and the newly fabricated SeNPs @vitamin C (SeNPs@VITC) nanocomposite in mitigating testicular toxicity induced by NIC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>The six groups of 48 adult Wistar rats were designed as follows: the control group injected intraperitoneally with normal saline, the SeNPs group treated orally with 2\u00a0mg\/kg of SeNPs, the SeNPs@VITC nanocomposite group treated orally with 2\u00a0mg\/kg of SeNPs@VITC nanocomposite, the NIC group injected intraperitoneally with 1.25\u00a0mL\/kg of NIC, the NIC+ SeNPs group received SeNPs plus NIC, and the NIC+ SeNPs@VITC nanocomposite group received SeNPs@VITC nanocomposite plus NIC. Treatments were administered over a 28-day period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>NIC treatment significantly caused poor sperm quality, decreased serum testosterone, increased follicle-stimulating hormone (FSH), luteinizing hormone (LH) concentrations, reduced hemoglobin levels, leukocytosis, disrupted testicular oxidant\/antioxidant balance, and disorganized testicular structure. The construction of the novel SeNPs@VITC nanocomposite, compared to NIC plus SeNPs alone, demonstrated a more potent ameliorative effect on NIC-induced reproductive toxicity in adult rats. The SeNPs@VITC nanocomposite significantly increased sperm count, reduced the percentage of sperm head abnormalities, lowered both serum FSH and LH concentrations, and improved the hemoglobin response.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Both SeNPs and SeNPs@VITC nanocomposite alleviated the testicular toxicity induced by NIC, but the SeNPs@VITC nanocomposite exhibited superior efficacy. The SeNPs@VITC nanocomposite could be employed to advance enhanced therapeutic strategies for addressing male infertility.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/toxres\/tfae154","type":"journal-article","created":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T16:34:22Z","timestamp":1726504462000},"source":"Crossref","is-referenced-by-count":3,"title":["Exploring the potential of selenium nanoparticles and fabricated selenium nanoparticles @vitamin C nanocomposite in mitigating nicotine-induced testicular toxicity in rats"],"prefix":"10.1093","volume":"13","author":[{"given":"Rana M M","family":"Refaat","sequence":"first","affiliation":[{"name":"Benha University Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, , Al Nadi Al Ryadi, Qism Benha, Al-Qalyubia Governorate, Benha 13518,","place":["Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atef E","family":"Fouda","sequence":"additional","affiliation":[{"name":"Benha University Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, , Al Nadi Al Ryadi, Qism Benha, Al-Qalyubia Governorate, Benha 13518,","place":["Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed A","family":"El-Shishtawy","sequence":"additional","affiliation":[{"name":"Benha University Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, , Al Nadi Al Ryadi, Qism Benha, Al-Qalyubia Governorate, Benha 13518,","place":["Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1198-3498","authenticated-orcid":false,"given":"Adarsh","family":"Kumar","sequence":"additional","affiliation":[{"name":"All India Institute of Medical Sciences (AIIMS) Department of Forensic Medicine and Toxicology, , AIIMS Campus, Ansari Nagar East, New Delhi,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7912-9979","authenticated-orcid":false,"given":"Nagi M","family":"El-Shafai","sequence":"additional","affiliation":[{"name":"Kafrelsheikh University Nanotechnology Center, Chemistry Department, Faculty of Science, , Qism Kafr El-Shaikh, Kafr Al Sheikh First, Kafr El-Sheikh Governorate, Kafrelsheikh 33516,","place":["Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8093-2769","authenticated-orcid":false,"given":"Eman M","family":"Faruk","sequence":"additional","affiliation":[{"name":"Umm Al-Qura University Anatomy Department, College of Medicine, , College of Medicine, Umm Al-Qura, University, Al Abidiyah, Makkah,","place":["Saudi Arabia"]},{"name":"Benha University Department of Histology and Cytology, Faculty of Medicine, , Al Nadi Al Ryadi, Qism Benha, Al-Qalyubia Governorate, Benha,","place":["Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6401-5514","authenticated-orcid":false,"given":"Ola E","family":"Nafea","sequence":"additional","affiliation":[{"name":"Zagazig University Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, , Zagazig Rd inside Zagazig University, Shaibet an Nakareyah, Al-Sharqia Governorate, Zagazig 44519,","place":["Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4234-0834","authenticated-orcid":false,"given":"Rabab F","family":"Hindawy","sequence":"additional","affiliation":[{"name":"Benha University Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, , Al Nadi Al Ryadi, Qism Benha, Al-Qalyubia Governorate, Benha 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