{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:35:04Z","timestamp":1787009704102,"version":"build-2736575974"},"reference-count":74,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T00:00:00Z","timestamp":1730764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,11,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Background: Cyclophosphamide, an immunosuppressive alkylating agent, has been used against breast cancer, lymphoma and myeloid leukemia. Despite various therapeutic uses, its toxic impacts on multiple organs remains to be fully elucidated. Aim: This study aimed to investigate dose dependent toxic impact of cyclophosphamide on liver, kidney, brain and testis emphasizing serum and tissue biochemical and histological alterations. Materials and methods: Experimental design consisted of five groups of albino rats. Group 1\u20135 were administered vehicle for five consecutive days. On 6th day, group 1 received vehicle only and termed as control; group 2\u20135 received cyclophosphamide through intraperitoneal route at the rate of 50, 100, 150 and 200\u00a0mg\/kg dose, respectively. After 24\u00a0h of the last administration, rats were euthanised; serum and tissue biochemistry; histology, sperm count and its motility were performed. Results: Serological, biochemical and histological indices exhibited dose dependent deviations from their regular status as a marker of toxicity in liver, kidney, brain and testis. Tukey\u2019s HSD post hoc test revealed maximum damage in multiple organs with 200\u00a0mg\/kg dose of cyclophosphamide.<\/jats:p>","DOI":"10.1093\/toxres\/tfae201","type":"journal-article","created":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T07:30:09Z","timestamp":1734334209000},"source":"Crossref","is-referenced-by-count":19,"title":["Cyclophosphamide-induced multiple organ dysfunctions: unravelling of dose dependent toxic impact on biochemistry and histology"],"prefix":"10.1093","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-7047-1818","authenticated-orcid":false,"given":"Asim Amitabh","family":"Sahu","sequence":"first","affiliation":[{"name":"Toxicology and Pharmacology Laboratory, Department of Zoology, Guru Ghasidas University , Ratanpur Road, Koni-Bilaspur, Chhattisgarh 495009 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