{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T18:45:38Z","timestamp":1780685138077,"version":"3.54.1"},"reference-count":67,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T00:00:00Z","timestamp":1730764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,11,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>About 80% of patients receiving chemotherapeutics suffer from side effects related to the gastrointestinal tract. Irinotecan (CPT-11) is a chemotherapeutic agent usually used in treating solid tumors. Quercetin (QRT), a bioflavonoid, is an antioxidant and scavenger reactive oxygen species scavenger.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>The current study explored the possible protective effects of QRT against mucosal tongue injury caused by CPT-11.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The study included four equal groups: group 1\/control, group 2\/QRT, group 3\/CPT-11, and group 4\/CPT-11\u00a0+\u00a0QRT.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>CPT-11-induced tongue injury in the form of non-healed ulcers, absent lingual papillae, mononuclear cells infiltration, marked deposition of collagen fibers, and overexpression of CD86 and tumor necrosis factor- \u03b1 (TNF-\u03b1). The increased malondialdehyde levels, decreased superoxide dismutase and total antioxidant capacity revealed that there was an oxidative stress. Also, there was a decreased countenance of Ki-67 and Bcl-2 and an increased countenance of NF-\u03baB. The QRT-treated group showed complete ulcer healing, with histological features almost like the control group, along with minimal collagen fiber deposition, decreased reactivity to CD86 and TNF-\u03b1 and improvement of oxidative stress status and the molecular study results as well.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>QRT possess protective properties against CPT-11-triggered tongue injury.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/toxres\/tfae214","type":"journal-article","created":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T06:43:06Z","timestamp":1734504186000},"source":"Crossref","is-referenced-by-count":1,"title":["Protective effects of quercetin against tongue injury and oxidative stress triggered by irinotecan: a histopathological, biochemical and molecular study"],"prefix":"10.1093","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8093-2769","authenticated-orcid":false,"given":"Eman Mohamed","family":"Faruk","sequence":"first","affiliation":[{"name":"Anatomy Department, College of Medicine, Umm Al-Qura University , Al Abidiyah, Makkah ,","place":["Saudi Arabia"]},{"name":"Department of Histology and Cell Biology, Faculty of Medicine, Benha University , Al Nadi Al Ryadi, Qism Benha 13518, Benha , Al-Qalyubia Governorate,","place":["Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0011-9389","authenticated-orcid":false,"given":"Fatma","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Zagazig University , Zagazig Rd inside Zagazig University, Shaibet an Nakareyah, Zagazig 44519, Al-Sharqia Governorate,","place":["Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1551-2035","authenticated-orcid":false,"given":"Mahmoud M","family":"Hassan","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, Benha University , Al Nadi Al Ryadi, Qism Benha, Al-Qalyubia Governorate, Benha 13518, Benha ,","place":["Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2990-3288","authenticated-orcid":false,"given":"Kamal M","family":"Kamal","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Embryology, Faculty of Medicine, Benha University , Al Nadi Al Ryadi, Qism Benha, Al-Qalyubia Governorate, Benha 13518, Benha ,","place":["Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2677-9318","authenticated-orcid":false,"given":"Dina Allam Abdelmaksoud","family":"Hassan","sequence":"additional","affiliation":[{"name":"Department of Histology and Cell Biology, Faculty of medicine for girls, Al-Azhar University , Cairo 11651,","place":["Cairo, Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5815-051X","authenticated-orcid":false,"given":"Ayat Abu-elnasr","family":"Awwad","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Faculty of Medicine, Al-Azhar University , Cairo 11751 ,","place":["Cairo, Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1402-2251","authenticated-orcid":false,"given":"Neama Mahmoud","family":"Taha","sequence":"additional","affiliation":[{"name":"Department of Physiology, Umm Al-Qura University , Al Abidiyah, Makkah ,","place":["Saudi 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