{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T19:50:27Z","timestamp":1789588227555,"version":"build-2803163510"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T00:00:00Z","timestamp":1735603200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Ovarian cancer (OC) is a significant cause of cancer-related mortality among women. This study explores the efficacy of Achillea millefolium L. (A. millefolium) extract, known for its phytoestrogenic properties, in treating OC through hormonal and metabolic modulation. Using a Wistar rat model, OC was induced with 7,12-dimethylbenz(a)anthracene (DMBA), and the effects of A. millefolium, both alone and in combination with paclitaxel (PTX), were evaluated. The study involved five groups of ten rats each: normal, OC, and those receiving 100\u00a0mg\/kg of A. millefolium with or without PTX. Key hormonal levels, oxidative stress markers, and inflammatory cytokines were measured. Additionally, ovarian tissues were analyzed for malondialdehyde and ferric reducing ability of plasma, while gene and protein expressions related to apoptosis were assessed. Results showed that A. millefolium, particularly when combined with PTX, reduced the luteinizing hormone\/follicle-stimulating hormone ratio, increased antioxidant enzyme activity, and upregulated apoptosis-related pathways, leading to higher p53 expression and fewer Ki-67 positive cells. These findings suggest A. millefolium\u2019s potential as a complementary therapy for women with OC, particularly those with ovulation disorders.<\/jats:p>","DOI":"10.1093\/toxres\/tfae235","type":"journal-article","created":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T10:49:16Z","timestamp":1736333356000},"source":"Crossref","is-referenced-by-count":2,"title":["Therapeutic potential of <i>Achillea millefolium<\/i> L. extract on 7,12-dimethylbenz(a)anthracene (DMBA) -induced ovary cancer in Wistar rats: a biochemical, molecular and histopathological approach"],"prefix":"10.1093","volume":"14","author":[{"given":"Linsen","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Clinical laboratory, Yantaishan Hospital , No. 91 Jiefang Road, Yantai, Shandong 264000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiu","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of obstetrical, The Affiliated Jiangning Hospital of Nanjing Medical University , No. 168, Gushan Road, Nanjing, Jiangsu 211100 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8815-3409","authenticated-orcid":false,"given":"Qingmei","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Jinggangshan University Clinical School of Medicine , No. 28 Xueyuan Road, Ji'an, Jiangxi 343000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,1,8]]},"reference":[{"key":"2025010912023995100_ref1","first-page":"561","article-title":"Ovarian cancer: an overview","volume":"91","author":"Penny","year":"2020","journal-title":"Radiol Technol"},{"key":"2025010912023995100_ref2","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1002\/humu.24158","article-title":"Whole-exome sequencing of non-BRCA1\/BRCA2 mutation carrier cases at high-risk for hereditary breast\/ovarian cancer","volume":"42","author":"Felicio","year":"2021","journal-title":"Hum Mutat"},{"key":"2025010912023995100_ref3","doi-asserted-by":"publisher","first-page":"112000","DOI":"10.1016\/j.biopha.2021.112000","article-title":"Liposomal paclitaxel induces apoptosis, cell death, inhibition of migration capacity and antitumoral activity in ovarian cancer","volume":"142","author":"Faria","year":"2021","journal-title":"Biomed Pharmacother"},{"key":"2025010912023995100_ref4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3892\/or.2021.8174","article-title":"Hormone therapy for ovarian cancer: emphasis on mechanisms and applications","volume":"46","author":"Li","year":"2021","journal-title":"Oncol Rep"},{"key":"2025010912023995100_ref5","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1002\/rmb2.12262","article-title":"Animal models of polycystic ovary syndrome: a review of hormone-induced rodent models focused on hypothalamus-pituitary-ovary axis and neuropeptides","volume":"18","author":"Osuka","year":"2019","journal-title":"Reprod Med Biol"},{"key":"2025010912023995100_ref6","doi-asserted-by":"publisher","first-page":"22","DOI":"10.4103\/jcrt.JCRT_862_16","article-title":"Oxidative stress and its role in cancer","volume":"17","author":"Jelic","year":"2021","journal-title":"J Cancer Res Ther"},{"key":"2025010912023995100_ref7","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1016\/j.apsusc.2019.05.099","article-title":"Zinc oxide nanoparticles induce oxidative and proteotoxic stress in ovarian cancer cells and trigger apoptosis independent of p53-mutation status","volume":"487","author":"Padmanabhan","year":"2019","journal-title":"Appl Surf Sci"},{"key":"2025010912023995100_ref8","doi-asserted-by":"publisher","first-page":"3035","DOI":"10.3390\/cancers13123035","article-title":"Inhibition of CDK4\/6 as therapeutic approach for ovarian cancer patients: current evidences and future perspectives","volume":"13","author":"Dall\u2019Acqua","year":"2021","journal-title":"Cancers"},{"key":"2025010912023995100_ref9","doi-asserted-by":"publisher","first-page":"113647","DOI":"10.1016\/j.phytochem.2023.113647","article-title":"Guaianolides from Achillea millefolium L. and their anti-inflammatory activity","volume":"210","author":"Li","year":"2023","journal-title":"Phytochemistry"},{"key":"2025010912023995100_ref10","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1080\/10412905.2022.2104392","article-title":"Beneficial effects of Achillea millefolium on skin injuries; a literature review","volume":"34","author":"Dalili","year":"2022","journal-title":"J Essent Oil Res"},{"key":"2025010912023995100_ref11","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.3390\/ph15091060","article-title":"Achillea fragrantissima (Forssk.) sch. 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