{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T02:00:35Z","timestamp":1789610435909,"version":"build-2803163510"},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Neuroscience Research Center of Kerman University of Medical Sciences","award":["99000458"],"award-info":[{"award-number":["99000458"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This study was designed to adjust effective chemotherapy doses of cabazitaxel (CBZ) on cognitive behaviors, inflammatory cytokines and oxidative stress parameters, and survival rate in C6-induced GBM of rats. Male Sprague\u2013Dawley rats bearing intra-caudate nucleus (CN) C6 inoculation were randomly divided into nine groups as follows: sham, tumor, Temozolomide (TMZ) vehicle, TMZ, CBZ vehicle, CBZ at doses of 0.5, 1, 2 and 4\u00a0mg\/kg. Behavioral tests survival rate, histopathology, immunohistochemistry, oxidative stress, and inflammatory cytokines were evaluated. All drug treatments reduced the volume and number of tumor cells dose-dependently and CBZ4 was able to cause the greatest reduction. The %Survival rate of animals using CBZ1 significantly increased compared to other treatment groups. CBZ1 reduced anxiety-like behaviors and increased the balance of the animal with GBM. CBZ1 and CBZ2 groups improved C6-induced learning disabilities. Treatments could ameliorate tumor-induced dysregulation of oxidative stress. TNF-\u03b1\/IL-10 decreased in the CBZ1 group compared to other treatment groups, which may indicate an improvement in inflammatory balance. Our findings demonstrate that the administration of CBZ at a dosage of 1\u00a0mg\/kg exerts advantageous impacts on both the survival rate and neurocognitive performance of rats within the GBM model. However, our results showed that CBZ may have toxic effects, especially in a dose of 4\u00a0mg\/kg.<\/jats:p>","DOI":"10.1093\/toxres\/tfaf048","type":"journal-article","created":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T16:36:13Z","timestamp":1743611773000},"source":"Crossref","is-referenced-by-count":9,"title":["Therapeutic efficacy to dose-dependent toxicity of Cabazitaxel in C6-induced glioblastoma model of rats"],"prefix":"10.1093","volume":"14","author":[{"given":"Zahra","family":"Mohammadzadeh","sequence":"first","affiliation":[{"name":"Department of Physiology and Pharmacology, Afzalipour School of Medicine, Kerman University of Medical Sciences , Haft-Bagh Highway, P. O. 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Box 76169 13439, Kerman ,","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amirhossein","family":"Moslemizadeh","sequence":"additional","affiliation":[{"name":"Department of Immunology, Tehran University of Medical Sciences , Dameshgh St., Vali-e Asr Ave., P. O. Box 14167 53955, Tehran ,","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sina","family":"Delshad","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, Faculty of Veterinary Medicine, Shahid Bahonar University of Kerman , Imam Khomeni Highway, P. O. Box 76169 13439, Kerman ,","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanaz","family":"Faramarz","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Kerman University of Medical Sciences , Haft-Bagh Highway, P. O. 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