{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T16:21:42Z","timestamp":1781713302650,"version":"3.54.5"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Korea government","award":["NRF-2023R1A2C1007657"],"award-info":[{"award-number":["NRF-2023R1A2C1007657"]}]},{"name":"Digital Infrastructure Building Project for Monitoring, Surveying and Evaluating the Environmental Health Program","award":["2021003330007"],"award-info":[{"award-number":["2021003330007"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Benzo(a)pyrene (B(a)P), a polycyclic aromatic hydrocarbon (PAH), is a known endocrine disruptor linked to various environmentally induced diseases. While recent studies have explored its role in short- and long-term disease development, there is limited research on B(a)P\u2019s cytotoxic effects across different cell types. This study aims to evaluate the cytotoxicity of B(a)P exposure in several human cell lines under controlled conditions. We employed flow cytometry (FACS) for quantitative cytotoxicity analysis at the single-cell level. Our findings revealed that B(a)P exhibited minimal cytotoxicity in lung and liver cells, but potent toxicity in breast cells. Notably, B(a)P-induced cytotoxicity in breast cells was associated with increased cleaved caspase-3 expression, leading to cell death. This process was further linked to cell cycle arrest, as indicated by altered cyclin B1 expression in a B(a)P-dependent manner, resulting in reduced cell viability. In summary, these results suggest that breast cells are particularly sensitive to B(a)P-induced cytotoxicity, which is driven by apoptosis and cell cycle disruption.<\/jats:p>","DOI":"10.1093\/toxres\/tfaf053","type":"journal-article","created":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T09:12:41Z","timestamp":1744621961000},"source":"Crossref","is-referenced-by-count":1,"title":["Benzo(a)pyrene triggers cytotoxicity by disrupting cell cycle dynamics and activating Caspase-3-mediated apoptosis in multiple human cell lines"],"prefix":"10.1093","volume":"14","author":[{"given":"Chul-Hong","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Life Science, Chung-Ang University , Heukseok-ro 84, Seoul 06974 ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geun-Seup","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Life Science, Chung-Ang University , Heukseok-ro 84, Seoul 06974 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