{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:18:47Z","timestamp":1753877927231,"version":"3.41.2"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T00:00:00Z","timestamp":1746144000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100013115","name":"Zhejiang Provincial Program for the Cultivation of High-Level Innovative Health Talents","doi-asserted-by":"publisher","award":["2020\u201318"],"award-info":[{"award-number":["2020\u201318"]}],"id":[{"id":"10.13039\/501100013115","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>With the widespread application of electromagnetic technology, electromagnetic fields (EMFs) emitted from various electric and electronic devices have significantly altered the electromagnetic environment. This has raised concerns about the potential health impacts of EMFs. Previous studies have indicated that EMFs may influence male infertility, with oxidative stress proposed as a key factor; however, the underlying mechanisms remain unclear. In this study, we aimed to determine whether EMFs enhance the impact of oxidative stress on male infertility. We investigated the effects of 50\u00a0Hz magnetic fields (MFs) on the sensitivity of mouse spermatogenic cell lines (GC-1 spg and GC-2 spd) to low-dose hydrogen peroxide (H2O2, 5 and 10\u00a0\u03bcM). Our findings revealed that pre-exposure to 2.0 mT 50\u00a0Hz MFs for 24\u00a0h increased the sensitivity of GC-2 spd cells to low-dose H2O2 in terms of \u03b3H2AX foci formation, a marker for DNA damage repair. However, no significant changes were observed in DNA fragmentation, cell viability, or cell cycle progression in either GC-1 spg or GC-2 spd cells. In conclusion, our results suggest that 50\u00a0Hz MFs do not significantly enhance the sensitivity of mouse spermatogenic cell lines to low-dose H2O2.<\/jats:p>","DOI":"10.1093\/toxres\/tfaf059","type":"journal-article","created":{"date-parts":[[2025,5,3]],"date-time":"2025-05-03T20:38:22Z","timestamp":1746304702000},"source":"Crossref","is-referenced-by-count":0,"title":["The effect of 50\u00a0Hz magnetic fields on cellular sensitivity of mouse spermatogenic cell lines to hydrogen peroxide"],"prefix":"10.1093","volume":"14","author":[{"given":"Xiaoxia","family":"Wei","sequence":"first","affiliation":[{"name":"Sir Run Run Shaw Hospital, Zhejiang University School of Medicine , 3 Qingchun East Road, Shangcheng District, Hangzhou 310016 ,","place":["China"]},{"name":"Bioelectromagnetics Laboratory, School of Public Health, Zhejiang University School of Medicine , 866 Yuhangtang Road, Xihu District, Hangzhou 310058 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Longtao","family":"Zhu","sequence":"additional","affiliation":[{"name":"Bioelectromagnetics Laboratory, School of Public Health, Zhejiang University School of Medicine , 866 Yuhangtang Road, Xihu District, Hangzhou 310058 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Zhu","sequence":"additional","affiliation":[{"name":"Bioelectromagnetics Laboratory, School of Public Health, Zhejiang University School of Medicine , 866 Yuhangtang Road, Xihu District, Hangzhou 310058 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyuan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Occupational Medicine and Environmental Toxicology, School of Public health, Nantong University , 9 Seyuan Road, Chongchuan District, Nantong 226019 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3495-5641","authenticated-orcid":false,"given":"Chuan","family":"Sun","sequence":"additional","affiliation":[{"name":"Zhejiang Key Laboratory of Geriatrics and Geriatrics Institute of Zhejiang Province, Zhejiang Hospital , 1229 Gudun Road, Xihu District, Hangzhou 310030 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangdi","family":"Chen","sequence":"additional","affiliation":[{"name":"Bioelectromagnetics Laboratory, School of Public Health, Zhejiang University School of Medicine , 866 Yuhangtang Road, Xihu District, Hangzhou 310058 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,5,3]]},"reference":[{"key":"2025050510564332200_ref1","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.pbiomolbio.2018.07.009","article-title":"Biological 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