{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T13:18:39Z","timestamp":1772111919104,"version":"3.50.1"},"reference-count":60,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T00:00:00Z","timestamp":1746144000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The main objective of this research was to investigate the therapeutic, anti-inflammatory, and histological effects of metformin and taurine, both alone and in combination, against thioacetamide (TAA)-induced hepatotoxicity in rats. The study included forty adult male Swiss albino rats, which were divided into five groups: Group I provided the control group. Group II (TAA group) rats received injections of TAA (200\u00a0mg\/kg b.wt \/3 times\/week, i.p.) for six weeks. Group III (TAA\u2009+\u2009metformin) rats received administration of metformin (200\u00a0mg\/kg\/day, p.o.) for five weeks. Group IV (TAA\u2009+\u2009taurine) rats received injections of taurine (100\u00a0mg\/kg\/day, i.p.) for five weeks, while Group V (TAA\u2009+\u2009metformin + taurine) rats received daily intraperitoneal injections and oral administration of the medication for five weeks. Inflammation and changes in liver function are hallmarks of TAA-induced hepatotoxicity. Our findings demonstrated that the greatly improved liver dysfunction might be attributed to the effects of metformin and taurine. Furthermore, a combination of metformin and taurine markedly inhibited inflammatory responses, as indicated by the decreased levels of the inflammatory cytokine IL-6. The biochemical results were confirmed by the histological analyses of the liver tissues. Post-treatments of metformin and taurine might have crucial potential and synergistic effects against TAA-induced hepatotoxicity.<\/jats:p>","DOI":"10.1093\/toxres\/tfaf076","type":"journal-article","created":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T07:01:43Z","timestamp":1749452503000},"source":"Crossref","is-referenced-by-count":2,"title":["The ameliorative effects of metformin and taurine against thioacetamide hepatotoxicity in rats"],"prefix":"10.1093","volume":"14","author":[{"given":"Sherouk S","family":"Badawy","sequence":"first","affiliation":[{"name":"Department of Chemistry, Faculty of Science, Mansoura University , Mansoura 35516 ,","place":["Egypt"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad M","family":"Mashaly","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science, Damietta University , New Damietta 34517 ,","place":["Egypt"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A 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