{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T04:34:29Z","timestamp":1782448469464,"version":"3.54.5"},"reference-count":62,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,7,5]],"date-time":"2025-07-05T00:00:00Z","timestamp":1751673600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Afyon Kocatepe University Scientific Research Projects Commission","award":["22.FENB\u0130L.16"],"award-info":[{"award-number":["22.FENB\u0130L.16"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>In this study, zinc oxide nanoparticles (ZnONPs) were synthesized by green synthesis technique using the extract obtained from Sideritis akmanii plant and the obtained ZnONPs were characterized by Ultraviolet\u2013Visible Spectrophotometry (UV\u2013VIS), X-Ray Diffraction (XRD) spectrophotometer, Scanning Electron Microscopy (SEM) and Fourier Transform Infrared Spectroscopy (FT-IR) techniques. Cytotoxic effects of both ZnONPs and Sideritis akmanii plant extract on A549 cells were investigated by MMT assay and genotoxic effects by Comet assay method. It was observed that the cytotoxic activity of ZnONP doses was higher than Sideritis akmanii plant extracts. In the comet test, the highest DNA damage (62.25\u2009\u00b1\u200910.15) was observed in the 10\u00a0mg\/mL ZnONP application at 48\u00a0h of application, DNA damage did not exceed the negative control group at 3 different plant extract doses. Moreover, the genotoxic effects of 4 different concentrations of ZnONPs (0.1, 1, 5, 10\u00a0mM) were evaluated on Drosophila melonagaster with the SMART test. The results obtained as a result of ZnONP application were found to be close to the control group and it was determined that no statistically significant genotoxic effect was observed. The antimicrobial activity of ZnONPs on Escherichia coli (ATCC 25922), Staphylococcus aureus (ATCC 29213), Salmonella enteritidis (ATCC 13076), Klebsiella pneumoniae (ATCC 700603) and Candida albicans (ATCC 90028) microorganisms was analyzed using disk diffusion method. According to the antimicrobial and antifungal activity data, it was determined that the synthesized ZnONPs were effective on all microorganism strains used in the study and the inhibition zone diameters ranged from 8 to 13.67\u00a0mm.<\/jats:p>","DOI":"10.1093\/toxres\/tfaf115","type":"journal-article","created":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T18:07:16Z","timestamp":1755022036000},"source":"Crossref","is-referenced-by-count":2,"title":["Biosynthesis of zinc oxide nanoparticles using Sideritis akmanii plant and evaluation of its biological activity"],"prefix":"10.1093","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7815-5366","authenticated-orcid":false,"given":"Arzu","family":"\u00d6zkara","sequence":"first","affiliation":[{"name":"Faculty of Arts and Sciences, Department of Molecular Biology and Genetics, Afyon Kocatepe University , Afyonkarahisar ,","place":["Turkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5427-9260","authenticated-orcid":false,"given":"Do\u011fukan","family":"\u0130\u015flek","sequence":"additional","affiliation":[{"name":"Afyon Kocatepe University, Institute of Science ,","place":["Turkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,8,6]]},"reference":[{"key":"2025081214071276800_ref1","doi-asserted-by":"publisher","first-page":"105656","DOI":"10.1016\/j.mimet.2019.105656","article-title":"Algae-based metallic nanoparticles: synthesis, characterization and applications","volume":"163","author":"Khanna","year":"2019","journal-title":"J Microbiol Methods"},{"key":"2025081214071276800_ref2","doi-asserted-by":"publisher","first-page":"102853","DOI":"10.1016\/j.jddst.2021.102853","article-title":"Bioengineered zinc oxide nanoparticles: chemical, green, biological fabrication methods and its potential biomedical applications","volume":"66","author":"Dutta","year":"2021","journal-title":"J Drug Deliv Sci Technol"},{"key":"2025081214071276800_ref3","doi-asserted-by":"publisher","first-page":"e11795","DOI":"10.1016\/j.heliyon.2022.e11795","article-title":"Application of nanotechnology in food: processing, preservation, packaging and safety assessment","volume":"8","author":"Biswas","year":"2022","journal-title":"Heliyon."},{"key":"2025081214071276800_ref4","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.spmi.2014.11.021","article-title":"Effect of microwave power on energy gap of ZnO nanoparticles synthesized by microwaving through aqueous solutions","volume":"78","author":"Promnopas","year":"2015","journal-title":"Superlattice Microst"},{"key":"2025081214071276800_ref5","doi-asserted-by":"publisher","first-page":"2931","DOI":"10.1016\/j.jmrt.2022.08.028","article-title":"Synthesis, characterization, and preliminary in vitro antibacterial evaluation of ZnO nanoparticles derived from soursop (Annona muricata L.) leaf extract as a green reducing agent","volume":"20","author":"Selvanathan","year":"2022","journal-title":"J Mat Res Technol"},{"key":"2025081214071276800_ref6","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1002\/bio.3180","article-title":"Synthesis of ZnO nanoparticles using a hydrothermal method and a study its optical activity","volume":"32","author":"Bharti","year":"2017","journal-title":"Luminescence."},{"key":"2025081214071276800_ref7","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.jphotobiol.2013.01.004","article-title":"Controllable synthesis of ZnO nanoparticles and their morphology-dependent antibacterial and optical properties","volume":"120","author":"Talebiana","year":"2013","journal-title":"J Photochem Photobiol B"},{"key":"2025081214071276800_ref8","doi-asserted-by":"publisher","first-page":"5973","DOI":"10.1166\/jnn.2009.1290","article-title":"Synthesis of ZnO nanoparticles by solvothermal method and their ammonia sensing properties","volume":"9","author":"Ghoshal","year":"2009","journal-title":"J Nanosci Nanotechnol"},{"key":"2025081214071276800_ref9","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/j.matdes.2015.07.087","article-title":"Basic zinc carbonate as a precursor in the solvothermal synthesis of nano-zinc oxide","volume":"86","author":"An\u017elovar","year":"2015","journal-title":"Mater Des"},{"key":"2025081214071276800_ref10","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1186\/2228-5326-3-30","article-title":"Synthesis, characterization and optical properties of zinc oxide nanoparticles. Int","volume":"3","author":"Kumar","year":"2013","journal-title":"Nano Lett"},{"key":"2025081214071276800_ref11","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.mee.2014.05.029","article-title":"Effects of temperature on the optical and electrical properties of ZnO nanoparticles synthesized by sol\u2013gel method","volume":"128","author":"Omria","year":"2014","journal-title":"Microelectron Eng"},{"key":"2025081214071276800_ref12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2014\/716210","article-title":"Direct precipitation and characterization of ZnO nanoparticles","volume":"2014","author":"Moharram","year":"2014","journal-title":"J Nanomater"},{"key":"2025081214071276800_ref13","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.jallcom.2011.11.118","article-title":"Aqueous starch as a stabilizer in zinc oxide nanoparticle synthesis via laser ablation","volume":"516","author":"Jajarmi","year":"2012","journal-title":"J Alloys Compd"},{"key":"2025081214071276800_ref14","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1016\/j.ultsonch.2007.11.003","article-title":"Growth mechanism and optical property of ZnO nanoparticles synthesized by sonochemical method","volume":"15","author":"Yadav","year":"2008","journal-title":"Ultrason Sonochem"},{"key":"2025081214071276800_ref15","first-page":"25","article-title":"Biosynthesis of silver nanoparticle by eco-friendly method","volume":"1","author":"Karnani","year":"2013","journal-title":"Ind J Nanosci"},{"key":"2025081214071276800_ref16","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.msec.2014.04.025","article-title":"Novel green synthetic strategy to prepare ZnO nanocrystals using rambutan (Nephelium lappaceum L.) peel extract and its antibacterial applications","volume":"41","author":"Yuvakkumar","year":"2014","journal-title":"Mat Sci Engineer C"},{"key":"2025081214071276800_ref17","doi-asserted-by":"publisher","first-page":"100848","DOI":"10.1016\/j.bbrep.2020.100848","article-title":"Green synthesis of silver nanoparticles using Ocimum canum and their anti-bacterial activity","volume":"24","author":"Tailor","year":"2020","journal-title":"Biochem Biophys Rep"},{"key":"2025081214071276800_ref18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s12034-018-1568-4","article-title":"Green synthesis of zinc oxide nanoparticles using aqueous extract of Garcinia mangostana fruit pericarp and their photocatalytic activity","volume":"41","author":"Aminuzzaman","year":"2018","journal-title":"Bull Mater Sci"},{"key":"2025081214071276800_ref19","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.3390\/biology10111075","article-title":"Green synthesis of zinc oxide nanoparticles using salvia officinalis leaf extract and their photocatalytic and antifungal activities","volume":"10","author":"Abomuti","year":"2021","journal-title":"Biology"},{"key":"2025081214071276800_ref20","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.jcis.2016.03.021","article-title":"Aloe vera extract functionalized zinc oxide nanoparticles as nanoantibiotics against multi-drug resistant clinical bacterial isolates","volume":"472","author":"Ali","year":"2016","journal-title":"J Colloid Interface Sci"},{"key":"2025081214071276800_ref21","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1016\/j.molstruc.2016.07.029","article-title":"Biosynthesis of ZnO nanoparticles using rambutan (Nephelium lappaceumL.) peel extract and their photocatalytic activity on methyl orange dye","volume":"1125","author":"Karnan","year":"2016","journal-title":"J Mol Struct"},{"key":"2025081214071276800_ref22","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1590\/s1984-82502016000400023","article-title":"Application of biosynthesized ZnO nanoparticles on an electrochemical H 2 O 2 biosensor","volume":"52","author":"Zheng","year":"2016","journal-title":"Braz J Pharm Sci"},{"key":"2025081214071276800_ref23","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1016\/j.sjbs.2015.05.016","article-title":"Biosynthesis and antibacterial activity of ZnO nanoparticles using Trifolium pratense flower extract","volume":"23","author":"Dobrucka","year":"2016","journal-title":"Saudi J Biol Sci"},{"key":"2025081214071276800_ref24","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/j.msec.2015.09.089","article-title":"Biofabrication of zinc oxide nanoparticles using fruit extract of Rosa canina and their toxic potential against bacteria: a mechanistic approach","volume":"59","author":"Jafarirad","year":"2016","journal-title":"Mater Sci Eng C"},{"key":"2025081214071276800_ref25","doi-asserted-by":"publisher","first-page":"1191","DOI":"10.31202\/ecjse.729462","article-title":"Green synthesis of zinc oxide nanoparticles using Zingiber officinale root extract and their applications in glucose biosensor","volume":"7","author":"D\u00f6nmez","year":"2020","journal-title":"El-Cezeri."},{"key":"2025081214071276800_ref26","doi-asserted-by":"publisher","first-page":"1639","DOI":"10.1016\/j.apt.2015.09.008","article-title":"Bio-approach: plant mediated synthesis of ZnO nanoparticles and their catalytic reduction of methylene blue and antimicrobial activity","volume":"26","author":"Elumalai","year":"2015","journal-title":"Adv Powder Technol"},{"key":"2025081214071276800_ref27","doi-asserted-by":"publisher","first-page":"106840","DOI":"10.1016\/j.microc.2021.106840","article-title":"Review on platinum nanoparticles: synthesis, characterization, and applications","volume":"171","author":"Khan","year":"2021","journal-title":"Microchem J"},{"key":"2025081214071276800_ref28","first-page":"221","article-title":"Three new species (Labiatae) from Turkey","volume":"5","author":"Duman","year":"1995","journal-title":"Flora Medit"},{"key":"2025081214071276800_ref29","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1002\/em.2860060206","article-title":"Somatic mutation and recombination test in Drosophila melanogaster","volume":"6","author":"Graf","year":"1984","journal-title":"Environ Mut"},{"key":"2025081214071276800_ref30","doi-asserted-by":"publisher","first-page":"111621","DOI":"10.1016\/j.jphotobiol.2019.111621","article-title":"Photocatalytic degradation of Rhodamine B by zinc oxide nanoparticles synthesized using the leaf extract of Cyanometra ramiflora","volume":"199","author":"Varadavenkatesan","year":"2019","journal-title":"J Photochem Photobiol Biol"},{"key":"2025081214071276800_ref31","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.jpcs.2018.12.005","article-title":"Green synthesis, characterization and antifungal and photocatalytic activity of Pithecellobium dulce peel\u2013mediated ZnO nanoparticles","volume":"127","author":"Madhumitha","year":"2019","journal-title":"J Phys Chem Solids"},{"key":"2025081214071276800_ref32","volume-title":"Ku\u015fburnu \u00e7ekirde\u011fi \u00f6z\u00fct\u00fcnden ye\u015fil sentez ile \u00e7inko oksit nanopartik\u00fcl sentezi ve karakterizasyonu. Istanbul University, Cerrahpa\u015fa graduate education institute, Master's thesis","author":"Bozkurt","year":"2022"},{"key":"2025081214071276800_ref33","doi-asserted-by":"publisher","first-page":"100426","DOI":"10.1016\/j.scp.2021.100426","article-title":"Aktumsek a (2021) green synthesis of silver nanoparticles using aqueous extracts of three Sideritis species from Turkey and evaluations bioactivity potentials","volume":"21","author":"Ceylan","year":"2021","journal-title":"Sustain Chem Pharm"},{"key":"2025081214071276800_ref34","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.scitotenv.2015.06.091","article-title":"Characterization of green zero-valent iron nanoparticles produced with tree leaf extracts","volume":"533","author":"Machado","year":"2015","journal-title":"Sci Total Environ"},{"key":"2025081214071276800_ref35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1063\/1.4945168","volume-title":"AIP conference proceedings","author":"Parveen","year":"2016"},{"key":"2025081214071276800_ref36","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1016\/j.reffit.2017.03.002","article-title":"A review on green synthesis of zinc oxide nanoparticles\u2013an eco-friendly approach","volume":"3","author":"Agarwal","year":"2017","journal-title":"Resource-Efficient Technol"},{"key":"2025081214071276800_ref37","doi-asserted-by":"publisher","first-page":"76","DOI":"10.4274\/tjps.galenos.2021.86422","article-title":"Essential oil content, antioxidative characteristics and enzyme inhibitory activity of Sideritis akmanii Ayta\u00e7, Ekici & D\u00f6nmez","volume":"19","author":"Aksoy","year":"2022","journal-title":"Turk J Pharm Sci"},{"key":"2025081214071276800_ref38","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1007\/s13201-021-01370-z","article-title":"A critical review of synthesis parameters affecting the properties of zinc oxide nanoparticle and its application in wastewater treatment","volume":"11","author":"Shaba","year":"2021","journal-title":"Appl Water Sci"},{"key":"2025081214071276800_ref39","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.enzmictec.2018.06.009","article-title":"Biosynthesis of zinc oxide nanoparticles using Mangifera indica leaves and evaluation of their antioxidant and cytotoxic properties in lung cancer (A549) cells","volume":"117","author":"Rajeshkumar","year":"2018","journal-title":"Enzym Microb Technol"},{"key":"2025081214071276800_ref40","doi-asserted-by":"publisher","first-page":"100179","DOI":"10.1016\/j.scp.2019.100179","article-title":"Anticancer and apoptotic activity of biologically synthesized zinc oxide nanoparticles against human colon cancer HCT-116 cell line in vitro study","volume":"14","author":"Majeed","year":"2019","journal-title":"Sustain Chem Pharm"},{"key":"2025081214071276800_ref41","doi-asserted-by":"publisher","first-page":"110831","DOI":"10.1016\/j.molliq.2019.04.108","article-title":"Ye\u015fil Juglans regia L. yaprak ekstresi kullan\u0131larak ve kimyasal y\u00f6ntemlerle sentezlenen \u00e7inko oksit nanopar\u00e7ac\u0131klar\u0131n\u0131n farkl\u0131 \u00f6zelliklerinin kar\u015f\u0131la\u015ft\u0131r\u0131lmas\u0131","volume":"286","author":"Darvishi","year":"2019","journal-title":"J Mol Liq"},{"key":"2025081214071276800_ref42","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.mssp.2018.03.017","article-title":"Materials science in semiconductor processing green synthesis of zinc oxide nanoparticles using Atalantia monophylla leaf extracts: characterization and antimicrobial analysis","volume":"82","author":"Vijayakumar","year":"2018","journal-title":"Mater Sci Semicond Process"},{"key":"2025081214071276800_ref43","doi-asserted-by":"publisher","first-page":"100532","DOI":"10.1016\/j.nanoso.2020.100532","article-title":"Mechanism of formation, characterization and cytotoxicity of green synthesized zinc oxide nanoparticles obtained from Ilex paraguariensis leaves extract","volume":"24","author":"Bandeira","year":"2020","journal-title":"Nano-Struct Nano-Obj"},{"key":"2025081214071276800_ref44","doi-asserted-by":"publisher","first-page":"111897","DOI":"10.1016\/j.envres.2021.111897","article-title":"Green synthesis, characterization and bioactivity of biogenic zinc oxide nanoparticles","volume":"204","author":"G\u00fcr","year":"2022","journal-title":"Environ Res"},{"key":"2025081214071276800_ref45","doi-asserted-by":"publisher","first-page":"198","DOI":"10.35472\/jsat.v5i1.372","article-title":"Green synthesis ZnO nanoparticles using rinds extract of sapindus rarak DC","volume":"5","author":"Yanti","year":"2021","journal-title":"J Sci Applicative Technol"},{"key":"2025081214071276800_ref46","doi-asserted-by":"publisher","first-page":"100695","DOI":"10.1016\/j.jics.2022.100695","article-title":"Green synthesis of ZnO nanoparticles using Acalypha indica leaf extract and their photocatalyst degradation and antibacterial activity","volume":"99","author":"Kamarajan","year":"2022","journal-title":"J Indian Chem Soc"},{"key":"2025081214071276800_ref47","doi-asserted-by":"publisher","first-page":"103577","DOI":"10.1016\/j.jddst.2022.103577","article-title":"Green synthesized zinc oxide nanoparticles from Cinnamomum verum bark extract inhibited cell growth and induced caspase-mediated apoptosis in oral cancer KB cells","volume":"74","author":"Shanmugam","year":"2022","journal-title":"J Drug Del Sci Technol"},{"key":"2025081214071276800_ref48","doi-asserted-by":"publisher","first-page":"125541","DOI":"10.1016\/j.matchemphys.2021.125541","article-title":"Anticancer and photocatalytic activities of zinc oxide nanorods synthesized from Manilkara littoralis leaf extract","volume":"277","author":"Ali","year":"2022","journal-title":"Mat Chem Phys"},{"key":"2025081214071276800_ref49","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.1007\/s42452-019-1058-3","article-title":"Effect of induced defects on the properties of ZnO nanocrystals: surfactant role and spectroscopic analysis","volume":"1","author":"Thongam","year":"2019","journal-title":"SN Appl Sci"},{"key":"2025081214071276800_ref50","doi-asserted-by":"publisher","first-page":"101925","DOI":"10.1016\/j.jddst.2020.101925","article-title":"Synthesis, characterization and cytotoxicity of zinc oxide nanoparticles by green synthesis method","volume":"60","author":"Patr\u00f3n-Romero","year":"2020","journal-title":"J Drug Del SciTechnol"},{"key":"2025081214071276800_ref51","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1007\/s10965-023-03461-8","article-title":"ZnO-containing nanocomposites produced from Mentha pulegium L. of a new HEMA-based methacrylate copolymer: improvement the thermal and antimicrobial effect","volume":"30","author":"Erol","year":"2023","journal-title":"J Polym Res"},{"key":"2025081214071276800_ref52","doi-asserted-by":"publisher","first-page":"2367","DOI":"10.1007\/s11164-016-2766-6","article-title":"Synthesis and characterization of zinc oxide nanoparticles using marine Streptomyces sp. with its investigations on anticancer and antibacterial activity","volume":"43","author":"Balraj","year":"2017","journal-title":"Res Chem Intermediat"},{"key":"2025081214071276800_ref53","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/j.mset.2019.12.004","article-title":"Capparis zeylanica mediated bio-synthesized ZnO nanoparticles as antimicrobial, photocatalytic and anti-cancer applications","volume":"3","author":"Nilavukkarasi","year":"2020","journal-title":"Mater Sci Energy Technol"},{"key":"2025081214071276800_ref54","doi-asserted-by":"publisher","first-page":"19","DOI":"10.18678\/dtfd.482351","article-title":"Enginar yapra\u011f\u0131 Sulu ekstrakt\u0131 kullan\u0131larak \u00e7inko oksit nanopartik\u00fcllerinin ye\u015fil sentezi, karakterizasyonu, anti-bakteriyel ve sitotoksik etkileri","volume":"21","author":"Erdo\u011fan","year":"2019","journal-title":"Duzce Med J"},{"key":"2025081214071276800_ref55","doi-asserted-by":"publisher","first-page":"e00595","DOI":"10.1016\/j.btre.2021.e00595","article-title":"Green synthesis of zinc oxide nanoparticles using leaf extracts of Raphanus sativus var. Longipinnatus and evaluation of their anticancer property in A549 cell lines","volume":"29","author":"Umamaheswari","year":"2021","journal-title":"Biotechnol Rep"},{"key":"2025081214071276800_ref56","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1007\/s10495-012-0705-6","article-title":"Zinc oxide nanoparticles induce oxidative DNA damage and ROS-triggered mitochondria mediated apoptosis in human liver cells (HepG2)","volume":"17","author":"Sharma","year":"2012","journal-title":"Apoptosis"},{"key":"2025081214071276800_ref57","doi-asserted-by":"publisher","first-page":"983","DOI":"10.2147\/IJN.S42028","article-title":"Induction of oxidative stress, DNA damage, and apoptosis in a malignant human skin melanoma cell line after exposure to zinc oxide nanoparticles","volume":"8","author":"Alarifi","year":"2013","journal-title":"Int J Nanomedicine"},{"key":"2025081214071276800_ref58","doi-asserted-by":"publisher","first-page":"104412","DOI":"10.1016\/j.etap.2024.104412","article-title":"In vivo assessment of the toxic impact of exposure to magnetic iron oxide nanoparticles (IONPs) using Drosophila melanogaster","volume":"107","author":"G\u00fcne\u015f","year":"2024","journal-title":"Environ Toxicol Pharmacol"},{"key":"2025081214071276800_ref59","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1177\/0748233717722907","article-title":"Genotoxic evaluation of different sizes of iron oxide nanoparticles and ionic form by SMART, allium and comet assay","volume":"33","author":"Kaygisiz","year":"2017","journal-title":"Toxicol Ind Health"},{"key":"2025081214071276800_ref60","doi-asserted-by":"publisher","first-page":"100230","DOI":"10.1016\/j.ceja.2021.100230","article-title":"Antonopoulou M assessment of the genotoxic potential of three novel composite nanomaterials using human lymphocytes and the fruit fly Drosophila melanogaster as model systems","volume":"9","author":"Efthimiou","year":"2022","journal-title":"Chem Eng J Adv"},{"key":"2025081214071276800_ref61","doi-asserted-by":"publisher","first-page":"104739","DOI":"10.1016\/j.mssp.2019.104739","article-title":"Periconium sp.(endophytic fungi) extract mediated sol-gel synthesis of ZnO nanoparticles for antimicrobial and antioxidant applications","volume":"105","author":"Ganesan","year":"2020","journal-title":"Mater Sci Semicond Process"},{"key":"2025081214071276800_ref62","doi-asserted-by":"publisher","first-page":"8519","DOI":"10.2147\/IJN.S271743","article-title":"Mycogenic synthesis of extracellular zinc oxide nanoparticles from Xylaria acuta and its nanoantibiotic potential","volume":"Volume 15","author":"Sumanth","year":"2020","journal-title":"Int J Nanomedicine"}],"container-title":["Toxicology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/toxres\/article-pdf\/14\/4\/tfaf115\/63968422\/tfaf115.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/toxres\/article-pdf\/14\/4\/tfaf115\/63968422\/tfaf115.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T18:07:18Z","timestamp":1755022038000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/toxres\/article\/doi\/10.1093\/toxres\/tfaf115\/8223317"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,5]]},"references-count":62,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,7,5]]}},"URL":"https:\/\/doi.org\/10.1093\/toxres\/tfaf115","relation":{},"ISSN":["2045-4538"],"issn-type":[{"value":"2045-4538","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,8]]},"published":{"date-parts":[[2025,7,5]]},"article-number":"tfaf115"}}