{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T03:24:04Z","timestamp":1792121044734,"version":"4.4.0"},"reference-count":127,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,9,7]],"date-time":"2025-09-07T00:00:00Z","timestamp":1757203200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The liver and kidneys are central to maintaining systemic homeostasis by removing endogenous and exogenous toxins. However, toxin accumulation can compromise these organs\u2019 detoxification capacity, leading to functional impairment and disease progression. Recent advances in nanotechnology have opened new avenues for enhancing detoxification strategies, particularly through the application of functionalized nanoparticles (NPs). Engineered NPs can selectively bind, sequester, or neutralize harmful compounds, while nano-adsorbents have shown promise in improving the efficiency of renal replacement therapies such as dialysis. Moreover, targeted nanocarriers enable site-specific drug delivery, minimizing off-target effects and enhancing therapeutic efficacy. This review explores the mechanistic interactions of NPs within hepatic and renal detoxification pathways, emphasizing their potential in managing hepatotoxicity and enhancing renal filtration. Highlighted case studies underscore the translational promise of NP-based interventions. Nevertheless, key challenges remain, including NP-induced immunogenicity, cytotoxicity, bioaccumulation, and regulatory hurdles. Future research should prioritize the optimization of NP biocompatibility, refinement of targeted delivery systems, and long-term safety evaluations. A deeper understanding of the nano\u2013bio interface is crucial for unlocking the full potential of nanotechnology in detoxification therapeutics. Addressing these challenges could usher in a new era of precision medicine for liver and kidney health.<\/jats:p>","DOI":"10.1093\/toxres\/tfaf137","type":"journal-article","created":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T11:48:39Z","timestamp":1756381719000},"source":"Crossref","is-referenced-by-count":5,"title":["Next- Gen Detox: Nanoparticles strategies for liver and kidney toxin removal"],"prefix":"10.1093","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5615-0142","authenticated-orcid":false,"given":"Muhammad","family":"Irfan","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Biotechnology, Hafiz Hayat Campus, Jalal Pur Jattan road, University of Gujrat , Gujrat 50700 ,","place":["Pakistan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5754-8626","authenticated-orcid":false,"given":"Rimsha","family":"Ansar","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biotechnology, Hafiz Hayat Campus, Jalal Pur Jattan road, University of Gujrat , Gujrat 50700 ,","place":["Pakistan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sehrish Bint","family":"Afzal","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biotechnology, Hafiz Hayat Campus, Jalal Pur Jattan road, University of Gujrat , Gujrat 50700 ,","place":["Pakistan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,10,23]]},"reference":[{"key":"2025102309182233600_ref1","doi-asserted-by":"publisher","first-page":"2209","DOI":"10.3390\/nu15092209","article-title":"Guided metabolic detoxification program supports phase II detoxification enzymes and antioxidant balance in healthy 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