{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T18:13:55Z","timestamp":1771870435858,"version":"3.50.1"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T00:00:00Z","timestamp":1769644800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Invasive aspergillosis (IA) is a severe fungal infection with complex pathogenesis, and the role of ferroptosis, an iron-dependent regulated cell death, in IA remains largely unexplored. This study investigates the association between ferroptosis and IA using a bioinformatics approach. We analyzed the GSE78000 dataset to assess ferroptosis activity and identify differentially expressed genes (DEGs). Ferroptosis-related genes (FRGs) were curated from literature, and protein\u2013protein interaction (PPI) networks and functional enrichment analyses (GO and KEGG) were performed. Three machine learning algorithms (SVM, LASSO, and Random Forest) identified five core FRGs (KIF20A, PEBP1, HMOX1, MTF1, QSOX1), which exhibited excellent diagnostic potential (AUCs: 0.884\u20130.981). IA patients were categorized into two ferroptosis-related subtypes (C1 and C2), characterized by distinct molecular profiles and pathway enrichments, such as ribosome biogenesis and DNA replication. Immune cell infiltration analysis, using ssGSEA, revealed significant alterations in IA, with increased innate immune cells (macrophages, neutrophils) positively correlating with core FRG expression, while adaptive immune cells (B cells, T cells) were decreased. Our findings indicate that ferroptosis is critically involved in IA pathogenesis, with identified core FRGs serving as promising diagnostic biomarkers. The revealed heterogeneity among IA patients and the interaction between ferroptosis and the immune microenvironment provide new insights into the disease\u2019s molecular mechanisms and potential therapeutic targets for further investigation.<\/jats:p>","DOI":"10.1093\/toxres\/tfag009","type":"journal-article","created":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T12:43:14Z","timestamp":1769776994000},"source":"Crossref","is-referenced-by-count":0,"title":["Integrated bioinformatic analysis identifies ferroptosis-related biomarkers and subtypes in invasive aspergillosis"],"prefix":"10.1093","volume":"15","author":[{"given":"Lu","family":"Tang","sequence":"first","affiliation":[{"name":"The Department of Respiratory and Critical Care Medicine, Shangjinnanfu Hospital, West China Hospital, Sichuan University , No. 253 Shangjin Road, Gaoxin West District (Pidu Hongguang), Chengdu, Sichuan Province 611730 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luying","family":"Yang","sequence":"additional","affiliation":[{"name":"The Department of Respiratory and Critical Care Medicine, The First Veterans Hospital of Sichuan Province , No. 86, Rongjun Road, Xinfan Town, Xindu District, Chengdu City, Sichuan Province 611730 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8734-9375","authenticated-orcid":false,"given":"Weiwei","family":"Qian","sequence":"additional","affiliation":[{"name":"The Department of Emergency, Shangjinnanfu Hospital, West China Hospital, Sichuan University , 253 Shangjin Road, High-tech West District, Pidu District, Chengdu, Sichuan 611730 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,2,23]]},"reference":[{"key":"2026022312233052700_ref1","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.medcli.2024.01.045","article-title":"Invasive aspergillosis: a comprehensive review","volume":"163","author":"Machado","year":"2024","journal-title":"Medicina clinica"},{"key":"2026022312233052700_ref2","doi-asserted-by":"publisher","first-page":"e33","DOI":"10.1016\/j.idc.2025.01.002","article-title":"Invasive aspergillosis in the current era","volume":"39","author":"Herrera","year":"2025","journal-title":"Infect Dis Clin N Am"},{"key":"2026022312233052700_ref3","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1016\/j.idc.2021.03.008","article-title":"Aspergillosis: epidemiology, diagnosis, and treatment","volume":"35","author":"Cadena","year":"2021","journal-title":"Infect Dis Clin N Am"},{"key":"2026022312233052700_ref4","doi-asserted-by":"publisher","first-page":"896","DOI":"10.3201\/eid3105.241392","article-title":"Features of invasive aspergillosis caused by aspergillus flavus, France, 2012-2018","volume":"31","author":"Bertin-Biasutto","year":"2025","journal-title":"Emerg Infect Dis"},{"key":"2026022312233052700_ref5","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1097\/QCO.0000000000000381","article-title":"Immune responses to invasive aspergillosis: new understanding and therapeutic opportunities","volume":"30","author":"Hohl","year":"2017","journal-title":"Curr Opin Infect Dis"},{"key":"2026022312233052700_ref6","doi-asserted-by":"crossref","first-page":"17096","DOI":"10.1038\/s41598-017-17000-1","article-title":"Modulation of immune Signaling and metabolism highlights host and fungal transcriptional responses in mouse models of invasive pulmonary aspergillosis","volume":"7","author":"Kale","year":"2017","journal-title":"Sci Rep"},{"key":"2026022312233052700_ref7","doi-asserted-by":"publisher","first-page":"e1007229","DOI":"10.1371\/journal.ppat.1007229","article-title":"Macrophages inhibit aspergillus fumigatus germination and neutrophil-mediated fungal killing","volume":"14","author":"Rosowski","year":"2018","journal-title":"PLoS Pathog"},{"key":"2026022312233052700_ref8","doi-asserted-by":"publisher","first-page":"1272","DOI":"10.4049\/jimmunol.1501811","article-title":"Human neutrophils use different mechanisms to kill aspergillus fumigatus conidia and hyphae: evidence from phagocyte defects","volume":"196","author":"Gazendam","year":"2016","journal-title":"Journal of immunology"},{"key":"2026022312233052700_ref9","doi-asserted-by":"crossref","first-page":"2346","DOI":"10.3389\/fimmu.2018.02346","article-title":"Allergic bronchopulmonary aspergillosis-a luminal Hypereosinophilic disease with extracellular trap cell death","volume":"9","author":"Ueki","year":"2018","journal-title":"Front Immunol"},{"key":"2026022312233052700_ref10","first-page":"100298","article-title":"PANoptosis opens new treatment options for allergic bronchopulmonary aspergillosis. 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