{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T18:13:55Z","timestamp":1771870435852,"version":"3.50.1"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T00:00:00Z","timestamp":1769644800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"2024 TETFUND Institution Based Research (IBR) Intervention"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Environmental toxins such as sodium arsenite induce oxidative stress, disrupt redox homeostasis, and trigger oncogenic signaling, providing a model for studying natural redox modulators. This study investigated the protective effects of Tapinanthus globiferus fractions (butanol, methanol, and ethyl acetate) on sodium arsenite\u2013exposed Drosophila melanogaster. Biochemical, behavioral, and molecular assays were employed to assess oxidative stress markers, enzyme activities, locomotor performance, cell viability, and gene expression. Sodium arsenite exposure significantly decreased acetylcholinesterase activity, total thiols, glutathione (GSH), glutathione-S-transferase (GST), and nitric oxide, while increasing hydrogen peroxide, lipid peroxidation, protein carbonyls, and metabolic hyperactivity. These alterations were effectively ameliorated by T. globiferus fractions, with the methanol and butanol fractions producing the most consistent improvements (P\u2009&amp;lt;\u20090.05). Behavioral assessment revealed that sodium arsenite reduced negative geotaxis performance to 39% climbing ability, which improved to 55% following butanol fraction treatment. Molecular analysis demonstrated that sodium arsenite suppressed p53 and SOD1 expression while inducing Ras and CNcC overexpression. Treatment with T. globiferus fractions restored p53 and SOD1 expression, suppressed Ras overexpression, and normalized CNcC transcription factor levels. These findings provide the in vivo evidence that T. globiferus mitigates arsenic-induced oxidative stress and genetic dysregulation through coordinated biochemical and transcriptional modulation. The dual ability to restore redox homeostasis and reprogram oncogenic signaling underscores its potential as a natural redox therapeutic against toxin-induced and carcinogenesis-linked pathologies.<\/jats:p>","DOI":"10.1093\/toxres\/tfag013","type":"journal-article","created":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T12:26:45Z","timestamp":1770035205000},"source":"Crossref","is-referenced-by-count":0,"title":["<i>Tapinanthus globiferus<\/i>\n                    mitigates arsenic-induced oxidative stress and genetic dysregulation In vivo"],"prefix":"10.1093","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2536-0072","authenticated-orcid":false,"given":"Jane-Rose I","family":"Oche","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Faculty of Basic Medical Sciences, College of Health Sciences, University of Jos , Jos, Plateau State \u00a0","place":["Nigeria"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan D","family":"Dabak","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Basic Medical Sciences, College of Health Sciences, University of Jos , Jos, Plateau State \u00a0","place":["Nigeria"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Titilayo O","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Basic Medical Sciences, College of Health Sciences, University of Jos , Jos, Plateau State \u00a0","place":["Nigeria"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,2,23]]},"reference":[{"key":"2026022312232659100_ref1","doi-asserted-by":"publisher","first-page":"1331","DOI":"10.1007\/s10653-022-01334-5","article-title":"Groundwater arsenic contamination: impacts on human health and agriculture, ex situ treatment techniques and alleviation","volume":"45","author":"Patel","year":"2023","journal-title":"Environ Geochem Health"},{"key":"2026022312232659100_ref2","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1038\/s43017-024-00519-z","article-title":"Arsenic and other geogenic contaminants in global groundwater","volume":"5","author":"Mukherjee","year":"2024","journal-title":"Nature Reviews Earth & Environment"},{"key":"2026022312232659100_ref3","doi-asserted-by":"crossref","first-page":"3108","DOI":"10.2166\/wst.2023.190","article-title":"A mini-review on arsenic remediation techniques from water and future trends","volume":"87","author":"Mahamallik","year":"2023","journal-title":"Water Sci Technol"},{"key":"2026022312232659100_ref4","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.3390\/app11041926","article-title":"Arsenic contamination of groundwater and its implications for drinking water quality and human health in under-developed countries and remote communities\u2014a review","volume":"11","author":"Adeloju","year":"2021","journal-title":"Appl Sci"},{"key":"2026022312232659100_ref5","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1007\/s13596-022-00644-4","article-title":"Potential involvement of opioidergic, \u03b11-adrenergic and serotonergic pathways in the anti-nociceptive actions of Tapinanthus globiferus a. rich (Loranthaceae) in mice","volume":"23","author":"Musa","year":"2023","journal-title":"Adv Tradit Med"},{"key":"2026022312232659100_ref6","doi-asserted-by":"crossref","first-page":"96","DOI":"10.31254\/phyto.2019.8303","article-title":"Anti-inflammatory potential of Tapinanthus globiferus (Loranthaceae) leaves as an alternative treatment against arthritis","volume":"8","author":"Raceline","year":"2019","journal-title":"The Journal of Phytopharmacology"},{"key":"2026022312232659100_ref7","first-page":"47019","article-title":"Phytochemical screening of African mistletoes Tapinanthus globiferus (a. rich) Tieghem (loranthaceae) on some host species in Birnin-Kebbi, Nigeria","volume":"107","author":"Malami","year":"2017","journal-title":"Elixir Biosciences"},{"key":"2026022312232659100_ref8","doi-asserted-by":"crossref","first-page":"124","DOI":"10.15171\/PS.2019.19","article-title":"Phytochemical screening and anti-inflammatory studies of Tapinanthus globiferus (a. rich) Teigh. 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