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Studies have shown that TBT targets the reproductive tract, impairing ovarian folliculogenesis, and uterine morphophysiology. In this investigation, we assessed whether subchronic and low dose of TBT exposure results in abnormal ovarian follicular reserve and other irregularities in female mice. TBT was administered to female mice (500\u2009ng\/kg\/day for 12\u2009days via gavage), and reproductive tract morphophysiology was assessed. We further assessed reproductive tract inflammation and oxidative stress. Improper functioning of the reproductive tract in TBT mice was observed. Specifically, irregular estrous cyclicity and abnormal ovarian morphology coupled with reduction in primordial and primary follicle numbers was observed, suggesting ovarian reserve depletion. In addition, improper follicular development and a reduction in antral follicles, corpora lutea, and total healthy ovarian follicles together with an increase in cystic follicles were apparent. Evidence of uterine atrophy, reduction in endometrial gland number, and inflammation and oxidative stress were seen in TBT mice. Further, strong negative correlations were observed between testosterone levels and primordial, primary, and total healthy ovarian follicles. Thus, these data suggest that the subchronic and low dose of TBT exposure impaired ovarian follicular reserve, uterine gland number, and other reproductive features in female mice.<\/jats:p>","DOI":"10.1093\/toxsci\/kfaa045","type":"journal-article","created":{"date-parts":[[2020,3,26]],"date-time":"2020-03-26T20:14:14Z","timestamp":1585253654000},"page":"74-85","source":"Crossref","is-referenced-by-count":24,"title":["Subchronic and Low Dose of Tributyltin Exposure Leads to Reduced Ovarian Reserve, Reduced Uterine Gland Number, and Other Reproductive Irregularities in Female Mice"],"prefix":"10.1093","volume":"176","author":[{"given":"Isabela V","family":"Sarmento","sequence":"first","affiliation":[{"name":"Department of Morphology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Merlo","sequence":"first","affiliation":[{"name":"Department of Morphology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvana S","family":"Meyrelles","sequence":"first","affiliation":[{"name":"Department of Physiology, Federal University of Espirito Santo, Vitoria, ES, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisardo C","family":"Vasquez","sequence":"first","affiliation":[{"name":"Department of Physiology, Federal University of Espirito Santo, Vitoria, ES, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genoa R","family":"Warner","sequence":"first","affiliation":[{"name":"Department of Comparative Biosciences, University of Illinois, Urbana, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andressa","family":"Gonsioroski","sequence":"first","affiliation":[{"name":"Department of Comparative Biosciences, University of Illinois, Urbana, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathy","family":"De La Torre","sequence":"first","affiliation":[{"name":"Department of Comparative Biosciences, University of Illinois, Urbana, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daryl D","family":"Meling","sequence":"first","affiliation":[{"name":"Department of Comparative Biosciences, University of Illinois, Urbana, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jodi A","family":"Flaws","sequence":"first","affiliation":[{"name":"Department of Comparative Biosciences, University of Illinois, Urbana, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9349-4369","authenticated-orcid":false,"given":"Jones B","family":"Graceli","sequence":"first","affiliation":[{"name":"Department of Morphology"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,4,1]]},"reference":[{"key":"2020071306122821000_kfaa045-B1","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.reprotox.2018.05.002","article-title":"Perinatal BPA exposure and reproductive axis function in CD-1 mice","volume":"79","author":"Acevedo","year":"2018","journal-title":"Reprod. 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