{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T09:51:23Z","timestamp":1792144283560,"version":"4.4.0"},"reference-count":74,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2020,5,11]],"date-time":"2020-05-11T00:00:00Z","timestamp":1589155200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001843","name":"SERB","doi-asserted-by":"publisher","award":["GAP359"],"award-info":[{"award-number":["GAP359"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001332","name":"CSIR","doi-asserted-by":"publisher","award":["BSC115"],"award-info":[{"award-number":["BSC115"]}],"id":[{"id":"10.13039\/501100001332","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Mitochondrial dysfunction is a common cause in pathophysiology of different neurodegenerative diseases. Elimination of dysfunctional and damaged mitochondria is a key requirement for maintaining homeostasis and bioenergetics of degenerating neurons. Using global microRNA (miRNA) profiling in a systemic rotenone model of Parkinson\u2019s disease, we have identified miR-146a as upmost-regulated miRNA, which is known as inflammation regulatory miRNA. Here, we report the role of activated nuclear factor kappa beta (NF-k\u03b2) in miR-146a-mediated downregulation of Parkin protein, which inhibits clearance of damaged mitochondria and induces neurodegeneration. Our studies have shown that 4-week rotenone exposure (2.5\u2009mg\/kg b.wt) induced oxidative imbalance-mediated NF-k\u03b2 activation in 1-year-old rat\u2019s brain. Activated NF-k\u03b2 binds in promoter region of miR-146a gene and induces its transcription, which downregulates levels of Parkin protein. Decreased amount of Parkin protein results in accumulation of damaged and dysfunctional mitochondria, which further promotes the generation of reactive oxygen species in degenerating neurons. In conclusion, our studies have identified direct role of NF-k\u03b2-mediated upregulation of miR-146a in regulating mitophagy through inhibition of the Parkin gene.<\/jats:p>","DOI":"10.1093\/toxsci\/kfaa066","type":"journal-article","created":{"date-parts":[[2020,5,5]],"date-time":"2020-05-05T19:19:27Z","timestamp":1588706367000},"page":"433-445","source":"Crossref","is-referenced-by-count":57,"title":["Coordinated Action of miR-146a and Parkin Gene Regulate Rotenone-induced Neurodegeneration"],"prefix":"10.1093","volume":"176","author":[{"given":"Abhishek","family":"Jauhari","sequence":"first","affiliation":[{"name":"Systems Toxicology and Health Risk Assessment Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Lucknow 226001, Uttar Pradesh, India"},{"name":"Academy of Scientific and Innovative Research (AcSIR), CSIR-IITR Campus, New Delhi, India"},{"name":"Department of Neurological Surgery, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanisha","family":"Singh","sequence":"additional","affiliation":[{"name":"Systems Toxicology and Health Risk Assessment Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Lucknow 226001, Uttar Pradesh, India"},{"name":"Department of Neurological Surgery, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saumya","family":"Mishra","sequence":"additional","affiliation":[{"name":"Systems Toxicology and Health Risk Assessment Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Lucknow 226001, Uttar Pradesh, India"},{"name":"Academy of Scientific and Innovative Research (AcSIR), CSIR-IITR Campus, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jai","family":"Shankar","sequence":"additional","affiliation":[{"name":"Systems Toxicology and Health Risk Assessment Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Lucknow 226001, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay","family":"Yadav","sequence":"additional","affiliation":[{"name":"Systems Toxicology and Health Risk Assessment Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Lucknow 226001, Uttar Pradesh, India"},{"name":"Academy of Scientific and Innovative Research (AcSIR), CSIR-IITR Campus, New Delhi, India"},{"name":"Department of Biochemistry, All India Institute of Medical Sciences, Raebareli-229405, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,5,11]]},"reference":[{"key":"2020081005563375600_kfaa066-B1","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1111\/jnc.13087","article-title":"Neuroprotective effects of vildagliptin in rat rotenone Parkinson\u2019s disease model: Role of RAGE-NF \u03baB and Nrf2-antioxidant signaling pathways","volume":"133","author":"Abdelsalam","year":"2015","journal-title":"J. Neurochem"},{"key":"2020081005563375600_kfaa066-B2","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.3233\/JAD-2010-091363","article-title":"An in vitro model for neuroscience: Differentiation of SH-SY5Y cells into cells with morphological and biochemical characteristics of mature neurons","volume":"20","author":"Agholme","year":"2010","journal-title":"J. Alzheimers Dis"},{"key":"2020081005563375600_kfaa066-B3","first-page":"25","article-title":"Apoptosis and autophagy in nigral neurons of patients with Parkinson\u2019s disease","volume":"12","author":"Anglade","year":"1997","journal-title":"Histol. Histopathol"},{"key":"2020081005563375600_kfaa066-B4","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1111\/j.1460-9568.2010.07122.x","article-title":"Expression pattern of miR-146a, an inflammation-associated microRNA, in experimental and human temporal lobe epilepsy","volume":"31","author":"Aronica","year":"2010","journal-title":"Eur. J. Neurosci"},{"key":"2020081005563375600_kfaa066-B5","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/cdd.2012.81","article-title":"The pathways of mitophagy for quality control and clearance of mitochondria","volume":"20","author":"Ashrafi","year":"2013","journal-title":"Cell Death Differ"},{"key":"2020081005563375600_kfaa066-B6","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1056\/NEJM199704103361506","article-title":"Nuclear factor-\u03baB\u2014A pivotal transcription factor in chronic inflammatory diseases","volume":"336","author":"Barnes","year":"1997","journal-title":"N. Engl. J. Med"},{"key":"2020081005563375600_kfaa066-B7","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1038\/81834","article-title":"Chronic systemic pesticide exposure reproduces features of Parkinson\u2019s disease","volume":"3","author":"Betarbet","year":"2000","journal-title":"Nat. Neurosci"},{"key":"2020081005563375600_kfaa066-B8","doi-asserted-by":"crossref","first-page":"402","DOI":"10.18632\/aging.100042","article-title":"MicroRNAs miR-146a\/b negatively modulate the senescence-associated inflammatory mediators IL-6 and IL-8","volume":"1","author":"Bhaumik","year":"2009","journal-title":"Aging"},{"key":"2020081005563375600_kfaa066-B9","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/j.ceb.2003.10.015","article-title":"Mitochondrial fission in apoptosis, neurodegeneration and aging","volume":"15","author":"Bossy-Wetzel","year":"2003","journal-title":"Curr. Opin. Cell Biol"},{"key":"2020081005563375600_kfaa066-B10","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.neurobiolaging.2003.04.001","article-title":"Poor and protracted myelination as a contributory factor to neurodegenerative disorders","volume":"25","author":"Braak","year":"2004","journal-title":"Neurobiol. Aging"},{"key":"2020081005563375600_kfaa066-B11","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.nbd.2009.01.016","article-title":"A highly reproducible rotenone model of Parkinson\u2019s disease","volume":"34","author":"Cannon","year":"2009","journal-title":"Neurobiol. Dis"},{"key":"2020081005563375600_kfaa066-B12","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.3390\/ijms19061689","article-title":"Microbiome-gut-brain axis and toll-like receptors in Parkinson\u2019s disease","volume":"19","author":"Caputi","year":"2018","journal-title":"Int. J. Mol. Sci"},{"key":"2020081005563375600_kfaa066-B13","doi-asserted-by":"crossref","first-page":"e22453","DOI":"10.1371\/journal.pone.0022453","article-title":"Low-level laser therapy activates NF-kB via generation of reactive oxygen species in mouse embryonic fibroblasts","volume":"6","author":"Chen","year":"2011","journal-title":"PLoS One"},{"key":"2020081005563375600_kfaa066-B14","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1126\/science.1231031","article-title":"PINK1-phosphorylated mitofusin 2 is a Parkin receptor for culling damaged mitochondria","volume":"340","author":"Chen","year":"2013","journal-title":"Science"},{"key":"2020081005563375600_kfaa066-B15","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1096\/fasebj.9.10.7542214","article-title":"Transcriptional regulation of endothelial cell adhesion molecules: NF-kappa B and cytokine-inducible enhancers","volume":"9","author":"Collins","year":"1995","journal-title":"FASEB J"},{"key":"2020081005563375600_kfaa066-B16","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.neuron.2010.04.034","article-title":"Genetic animal models of Parkinson\u2019s disease","volume":"66","author":"Dawson","year":"2010","journal-title":"Neuron"},{"key":"2020081005563375600_kfaa066-B17","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.bbamcr.2010.08.007","article-title":"Mitophagy and Parkinson\u2019s disease: The PINK1\u2013Parkin link","volume":"1813","author":"Deas","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"2020081005563375600_kfaa066-B18","doi-asserted-by":"crossref","first-page":"14503","DOI":"10.1073\/pnas.0803998105","article-title":"The Parkinson\u2019s disease genes PINK1 and Parkin promote mitochondrial fission and\/or inhibit fusion in drosophila","volume":"105","author":"Deng","year":"2008","journal-title":"Proc. Natl. Acad. Sci"},{"key":"2020081005563375600_kfaa066-B19","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1101\/gad.262758.115","article-title":"The three \u2018P\u2019s of mitophagy: Parkin, PINK1, and post-translational modifications","volume":"29","author":"Durcan","year":"2015","journal-title":"Genes Dev"},{"key":"2020081005563375600_kfaa066-B20","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1089\/dna.2015.2953","article-title":"Pycnogenol protects against rotenone-induced neurotoxicity in PC12 cells through regulating NF-\u03baB-iNOS signaling pathway","volume":"34","author":"Gao","year":"2015","journal-title":"DNA Cell Biol"},{"key":"2020081005563375600_kfaa066-B21","doi-asserted-by":"crossref","first-page":"527","DOI":"10.3389\/fneur.2017.00527","article-title":"Mitophagy in Parkinson\u2019s disease: Pathogenic and therapeutic implications","volume":"8","author":"Gao","year":"2017","journal-title":"Front. Neurol"},{"key":"2020081005563375600_kfaa066-B22","doi-asserted-by":"crossref","first-page":"e23837","DOI":"10.1371\/journal.pone.0023837","article-title":"Regulation of miR-146a by ReLA\/NFkB and P53 in STHdhQ111\/HdhQ111 cells, a cell model of Huntington\u2019s disease","volume":"6","author":"Ghose","year":"2011","journal-title":"PLoS One"},{"key":"2020081005563375600_kfaa066-B23","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1126\/science.1109020","article-title":"MicroRNAs regulate brain morphogenesis in zebrafish","volume":"308","author":"Giraldez","year":"2005","journal-title":"Science"},{"key":"2020081005563375600_kfaa066-B24","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S1353-8020(03)00023-3","article-title":"The rotenone model of Parkinson\u2019s disease: Genes, environment and mitochondria","volume":"9","author":"Greenamyre","year":"2003","journal-title":"Parkinsonism Relat. Disord"},{"key":"2020081005563375600_kfaa066-B25","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.gene.2014.10.024","article-title":"MicroRNA-146a reduces IL-1 dependent inflammatory responses in the intervertebral disc","volume":"555","author":"Gu","year":"2015","journal-title":"Gene"},{"key":"2020081005563375600_kfaa066-B26","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.expneurol.2005.01.013","article-title":"Oxidative stress and inflammation in Parkinson\u2019s disease: Is there a causal link?","volume":"193","author":"Hald","year":"2005","journal-title":"Exp. Neurol"},{"key":"2020081005563375600_kfaa066-B27","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1111\/jnc.13412","article-title":"Mitochondrial and lysosomal biogenesis are activated following PINK1\/Parkin-mediated mitophagy","volume":"136","author":"Ivankovic","year":"2016","journal-title":"J. Neurochem"},{"key":"2020081005563375600_kfaa066-B28","doi-asserted-by":"crossref","first-page":"4986","DOI":"10.1007\/s12035-016-0042-9","article-title":"Differentiation induces dramatic changes in miRNA profile, where loss of Dicer diverts differentiating SH-SY5Y cells toward senescence","volume":"54","author":"Jauhari","year":"2017","journal-title":"Mol. Neurobiol"},{"key":"2020081005563375600_kfaa066-B29","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1007\/s12035-016-0359-4","article-title":"Regulation of miR-34 family in neuronal development","volume":"55","author":"Jauhari","year":"2018","journal-title":"Mol. Neurobiol"},{"key":"2020081005563375600_kfaa066-B30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12035-018-1009-9","article-title":"Expression of miR-145 and its target proteins are regulated by miR-29b in differentiated neurons","volume":"55","author":"Jauhari","year":"2018","journal-title":"Mol. Neurobiol"},{"key":"2020081005563375600_kfaa066-B31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12017-019-08535-9","article-title":"miR-34 and miR-200: Regulator of cell fate plasticity and neural development","volume":"21","author":"Jauhari","year":"2019","journal-title":"Neuromol. Med"},{"key":"2020081005563375600_kfaa066-B32","doi-asserted-by":"crossref","first-page":"2800","DOI":"10.1002\/dvdy.22109","article-title":"Different timings of Dicer deletion affect neurogenesis and gliogenesis in the developing mouse central nervous system","volume":"238","author":"Kawase-Koga","year":"2009","journal-title":"Dev. Dyn"},{"key":"2020081005563375600_kfaa066-B33","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.abb.2007.03.034","article-title":"Selective degradation of mitochondria by mitophagy","volume":"462","author":"Kim","year":"2007","journal-title":"Arch. Biochem. Biophys"},{"key":"2020081005563375600_kfaa066-B34","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/ncpneuro0126","article-title":"The genetics of Parkinson disease: Implications for neurological care","volume":"2","author":"Klein","year":"2006","journal-title":"Nat. Rev. Neurol"},{"key":"2020081005563375600_kfaa066-B35","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/nrn2417","article-title":"Mitochondrial fragmentation in neurodegeneration","volume":"9","author":"Knott","year":"2008","journal-title":"Nat. Rev. Neurosci"},{"key":"2020081005563375600_kfaa066-B36","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s10059-012-0100-8","article-title":"PINK1 as a molecular checkpoint in the maintenance of mitochondrial function and integrity","volume":"34","author":"Koh","year":"2012","journal-title":"Mol. Cells"},{"key":"2020081005563375600_kfaa066-B37","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1515\/BC.1999.106","article-title":"Role of mitochondria in Parkinson disease","volume":"380","author":"K\u00f6sel","year":"1999","journal-title":"Biol. Chem"},{"key":"2020081005563375600_kfaa066-B38","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.brainres.2010.04.002","article-title":"MicroRNAs in neural cell differentiation","volume":"1338","author":"Lau","year":"2010","journal-title":"Brain Res"},{"key":"2020081005563375600_kfaa066-B39","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1186\/s12974-018-1278-2","article-title":"Inhibition of NF-\u03baB in astrocytes is sufficient to delay neurodegeneration induced by proteotoxicity in neurons","volume":"15","author":"Li","year":"2018","journal-title":"J. Neuroinflamm"},{"key":"2020081005563375600_kfaa066-B40","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1056\/NEJM200005253422103","article-title":"Association between early-onset Parkinson\u2019s disease and mutations in the Parkin gene","volume":"342","author":"L\u00fccking","year":"2000","journal-title":"N. Engl. J. Med"},{"key":"2020081005563375600_kfaa066-B41","doi-asserted-by":"crossref","first-page":"31315","DOI":"10.1074\/jbc.M805371200","article-title":"An NF-\u03baB-sensitive micro RNA-146a-mediated inflammatory circuit in Alzheimer disease and in stressed human brain cells","volume":"283","author":"Lukiw","year":"2008","journal-title":"J. Biol. Chem"},{"key":"2020081005563375600_kfaa066-B42","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1172\/JCI11916","article-title":"NF-\u03baB in neuronal plasticity and neurodegenerative disorders","volume":"107","author":"Mattson","year":"2001","journal-title":"J. Clin. Invest"},{"key":"2020081005563375600_kfaa066-B43","doi-asserted-by":"crossref","first-page":"a009282","DOI":"10.1101\/cshperspect.a009282","article-title":"Motor control abnormalities in Parkinson\u2019s disease","volume":"2","author":"Mazzoni","year":"2012","journal-title":"Cold Spring Harb. Perspect. Med"},{"key":"2020081005563375600_kfaa066-B44","doi-asserted-by":"crossref","first-page":"706","DOI":"10.4161\/auto.5.5.8505","article-title":"Parkin-induced mitophagy in the pathogenesis of Parkinson disease","volume":"5","author":"Narendra","year":"2009","journal-title":"Autophagy"},{"key":"2020081005563375600_kfaa066-B45","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/S0166-2236(96)01035-1","article-title":"NF-kB: A crucial transcription factor for glial and neuronal cell function","volume":"20","author":"O'Neill","year":"1997","journal-title":"Trends Neurosci"},{"key":"2020081005563375600_kfaa066-B46","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1093\/brain\/awm318","article-title":"The role of autophagy-lysosome pathway in neurodegeneration associated with Parkinson\u2019s disease","volume":"131","author":"Pan","year":"2008","journal-title":"Brain"},{"key":"2020081005563375600_kfaa066-B47","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1039\/C5TX00200A","article-title":"Transactivation of P53 by cypermethrin induced miR-200 and apoptosis in neuronal cells","volume":"4","author":"Pandey","year":"2015","journal-title":"Toxicol. Res"},{"key":"2020081005563375600_kfaa066-B48","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1111\/jnc.13089","article-title":"Critical role of the miR-200 family in regulating differentiation and proliferation of neurons","volume":"133","author":"Pandey","year":"2015","journal-title":"J. Neurochem"},{"key":"2020081005563375600_kfaa066-B49","doi-asserted-by":"crossref","first-page":"42026","DOI":"10.1074\/jbc.M508628200","article-title":"Rotenone model of Parkinson disease multiple brain mitochondria dysfunctions after short term systemic rotenone intoxication","volume":"280","author":"Panov","year":"2005","journal-title":"J. Biol. Chem"},{"key":"2020081005563375600_kfaa066-B50","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.neuron.2014.12.007","article-title":"The roles of PINK1, Parkin, and mitochondrial fidelity in Parkinson\u2019s disease","volume":"85","author":"Pickrell","year":"2015","journal-title":"Neuron"},{"key":"2020081005563375600_kfaa066-B51","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1126\/science.276.5321.2045","article-title":"Mutation in the \u03b1-synuclein gene identified in families with Parkinson\u2019s disease","volume":"276","author":"Polymeropoulos","year":"1997","journal-title":"Science"},{"key":"2020081005563375600_kfaa066-B52","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.neuint.2006.02.003","article-title":"Rotenone induces cell death in primary dopaminergic culture by increasing ROS production and inhibiting mitochondrial respiration","volume":"49","author":"Radad","year":"2006","journal-title":"Neurochem. Int"},{"key":"2020081005563375600_kfaa066-B53","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.tibs.2015.02.003","article-title":"Mitochondrial dysfunction and mitophagy in Parkinson\u2019s: From familial to sporadic disease","volume":"40","author":"Ryan","year":"2015","journal-title":"Trends Biochem. Sci"},{"key":"2020081005563375600_kfaa066-B54","doi-asserted-by":"crossref","first-page":"e30832","DOI":"10.1371\/journal.pone.0030832","article-title":"MicroRNA 146a (miR-146a) is over-expressed during prion disease and modulates the innate immune response and the microglial activation state","volume":"7","author":"Saba","year":"2012","journal-title":"PLoS One"},{"key":"2020081005563375600_kfaa066-B55","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1172\/JCI29178","article-title":"Diagnosis and treatment of Parkinson disease: Molecules to medicine","volume":"116","author":"Savitt","year":"2006","journal-title":"J. Clin. Invest"},{"key":"2020081005563375600_kfaa066-B56","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1111\/j.1471-4159.1990.tb02325.x","article-title":"Mitochondrial complex I deficiency in Parkinson\u2019s disease","volume":"54","author":"Schapira","year":"1990","journal-title":"J. Neurochem"},{"key":"2020081005563375600_kfaa066-B57","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1002\/mds.23732","article-title":"Etiology and pathogenesis of Parkinson\u2019s disease","volume":"26","author":"Schapira","year":"2011","journal-title":"Mov. Disord"},{"key":"2020081005563375600_kfaa066-B58","first-page":"192","article-title":"Environment, mitochondria, and Parkinson\u2019s disease","volume":"8","author":"Sherer","year":"2002","journal-title":"Neuroscientist"},{"key":"2020081005563375600_kfaa066-B59","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0304-3940(03)00172-1","article-title":"Selective microglial activation in the rat rotenone model of Parkinson\u2019s disease","volume":"341","author":"Sherer","year":"2003","journal-title":"Neurosci. Lett"},{"key":"2020081005563375600_kfaa066-B60","doi-asserted-by":"crossref","first-page":"7006","DOI":"10.1523\/JNEUROSCI.22-16-07006.2002","article-title":"An in vitro model of Parkinson\u2019s disease: Linking mitochondrial impairment to altered \u03b1-synuclein metabolism and oxidative damage","volume":"22","author":"Sherer","year":"2002","journal-title":"J. Neurosci"},{"key":"2020081005563375600_kfaa066-B61","doi-asserted-by":"crossref","first-page":"10756","DOI":"10.1523\/JNEUROSCI.23-34-10756.2003","article-title":"Mechanism of toxicity in rotenone models of Parkinson\u2019s disease","volume":"23","author":"Sherer","year":"2003","journal-title":"J. Neurosci"},{"key":"2020081005563375600_kfaa066-B62","doi-asserted-by":"crossref","first-page":"77","DOI":"10.3389\/fnmol.2015.00077","article-title":"NF-kappaB signaling pathways in neurological inflammation: A mini review","volume":"8","author":"Shih","year":"2015","journal-title":"Front. Mol. Neurosci"},{"key":"2020081005563375600_kfaa066-B63","doi-asserted-by":"crossref","first-page":"96","DOI":"10.2174\/18715273113126660190","article-title":"Regulatory triangle of neurodegeneration, adult neurogenesis and microRNAs","volume":"13","author":"Singh","year":"2014","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"2020081005563375600_kfaa066-B64","doi-asserted-by":"crossref","first-page":"101068","DOI":"10.1016\/j.arr.2020.101068","article-title":"Role of microRNAs in neurodegeneration induced by environmental neurotoxicants and aging","volume":"60","author":"Singh","year":"2020","journal-title":"Ageing Res. Rev"},{"key":"2020081005563375600_kfaa066-B65","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.expneurol.2018.01.015","article-title":"Guanabenz promotes neuronal survival via enhancement of ATF4 and Parkin expression in models of Parkinson disease","volume":"303","author":"Sun","year":"2018","journal-title":"Exp. Neurol"},{"key":"2020081005563375600_kfaa066-B66","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.molbrainres.2004.11.007","article-title":"Rotenone induces oxidative stress and dopaminergic neuron damage in organotypic substantia nigra cultures","volume":"134","author":"Testa","year":"2005","journal-title":"Mol. Brain Res"},{"key":"2020081005563375600_kfaa066-B67","doi-asserted-by":"crossref","first-page":"S155","DOI":"10.1002\/mds.22781","article-title":"Mitochondrial therapies for Parkinson\u2019s disease","volume":"25","author":"Thomas","year":"2010","journal-title":"Mov. Disord"},{"key":"2020081005563375600_kfaa066-B68","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.2174\/1871527313666140806144831","article-title":"Receptor for ages (RAGE) as mediator of NF-kB pathway activation in neuroinflammation and oxidative stress","volume":"13","author":"Tobon-Velasco","year":"2014","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"2020081005563375600_kfaa066-B69","doi-asserted-by":"crossref","first-page":"4390","DOI":"10.1093\/hmg\/ddp394","article-title":"Leucine-rich repeat kinase 2 interacts with Parkin, DJ-1 and PINK-1 in a drosophila melanogaster model of Parkinson\u2019s disease","volume":"18","author":"Venderova","year":"2009","journal-title":"Hum. Mol. Genet"},{"key":"2020081005563375600_kfaa066-B70","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.molmed.2010.11.002","article-title":"Mitophagy: The latest problem for Parkinson\u2019s disease","volume":"17","author":"Vives-Bauza","year":"2011","journal-title":"Trends Mol. Med"},{"key":"2020081005563375600_kfaa066-B71","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1038\/sj.bjp.0707167","article-title":"Inflammation as a causative factor in the aetiology of Parkinson\u2019s disease","volume":"150","author":"Whitton","year":"2007","journal-title":"Br. J. Pharmacol"},{"key":"2020081005563375600_kfaa066-B72","first-page":"1086","article-title":"SH-SY5Y human neuroblastoma cell line: In vitro cell model of dopaminergic neurons in Parkinson\u2019s disease","volume":"123","author":"Xie","year":"2010","journal-title":"Chin. Med. J"},{"key":"2020081005563375600_kfaa066-B73","doi-asserted-by":"crossref","first-page":"37347","DOI":"10.1074\/jbc.M111.235531","article-title":"miR-497 and miR-302b regulate ethanol induced neuronal cell death through BCL2 and cyclin D2","volume":"286","author":"Yadav","year":"2011","journal-title":"J. Biol. Chem"},{"key":"2020081005563375600_kfaa066-B74","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.neo.2017.02.001","article-title":"MIR155 regulation of ubiquilin1 and ubiquilin2: Implications in cellular protection and tumorigenesis","volume":"19","author":"Yadav","year":"2017","journal-title":"Neoplasia"}],"container-title":["Toxicological Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/toxsci\/advance-article-pdf\/doi\/10.1093\/toxsci\/kfaa066\/33400479\/kfaa066.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/toxsci\/article-pdf\/176\/2\/433\/33629813\/kfaa066.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/toxsci\/article-pdf\/176\/2\/433\/33629813\/kfaa066.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,10]],"date-time":"2020-08-10T09:57:20Z","timestamp":1597053440000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/toxsci\/article\/176\/2\/433\/5835884"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,11]]},"references-count":74,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2020,5,11]]},"published-print":{"date-parts":[[2020,8,1]]}},"URL":"https:\/\/doi.org\/10.1093\/toxsci\/kfaa066","relation":{},"ISSN":["1096-6080","1096-0929"],"issn-type":[{"value":"1096-6080","type":"print"},{"value":"1096-0929","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,8]]},"published":{"date-parts":[[2020,5,11]]}}}