{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T02:59:41Z","timestamp":1740106781259,"version":"3.37.3"},"reference-count":74,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2021,1,23]],"date-time":"2021-01-23T00:00:00Z","timestamp":1611360000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurologic Disorders and Stroke","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"name":"UC Davis CounterACT Center of Excellence","award":["U54 NS079202"],"award-info":[{"award-number":["U54 NS079202"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,4,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Tetramethylenedisulfotetramine (tetramine or TETS), a potent convulsant, triggers abnormal electrical spike activity (ESA) and synchronous Ca2+ oscillation (SCO) patterns in cultured neuronal networks by blocking gamma-aminobutyric acid (GABAA) receptors. Murine hippocampal neuronal\/glial cocultures develop extensive dendritic connectivity between glutamatergic and GABAergic inputs and display two distinct SCO patterns when imaged with the Ca2+ indicator Fluo-4: Low amplitude SCO events (LASE) and High amplitude SCO events (HASE) that are dependent on TTX-sensitive network electrical spike activity (ESA). Acute TETS (3.0\u2009\u00b5M) increased overall network SCO amplitude and decreased SCO frequency by stabilizing HASE and suppressing LASE while increasing ESA. In multielectrode arrays, TETS also increased burst frequency and synchronicity. In the presence of TETS (3.0\u2009\u00b5M), the clinically used anticonvulsive perampanel (0.1\u20133.0\u2009\u00b5M), a noncompetitive AMPAR antagonist, suppressed all SCO activity, whereas the GABAA receptor potentiator midazolam (1.0-30\u2009\u00b5M), the current standard of care, reciprocally suppressed HASE and stabilized LASE. The neuroactive steroid (NAS) allopregnanolone (0.1\u20133.0\u2009\u00b5M) normalized TETS-triggered patterns by selectively suppressing HASE and increasing LASE, a pharmacological pattern distinct from its epimeric form eltanolone, ganaxolone, alphaxolone, and XJ-42, which significantly potentiated TETS-triggered HASE in a biphasic manner. Cortisol failed to mitigate TETS-triggered patterns and at &amp;gt;1\u2009\u00b5M augmented them. Combinations of allopregnanolone and midazolam were significantly more effective at normalizing TETS-triggered SCO patterns, ESA patterns, and more potently enhanced GABA-activated Cl\u2212 current, than either drug alone.<\/jats:p>","DOI":"10.1093\/toxsci\/kfab007","type":"journal-article","created":{"date-parts":[[2021,1,13]],"date-time":"2021-01-13T17:28:24Z","timestamp":1610558904000},"page":"325-341","source":"Crossref","is-referenced-by-count":6,"title":["Structure-Activity Relationship of Neuroactive Steroids, Midazolam, and Perampanel Toward Mitigating Tetramine-Triggered Activity in Murine Hippocampal Neuronal Networks"],"prefix":"10.1093","volume":"180","author":[{"given":"Shane","family":"Antrobus","sequence":"first","affiliation":[{"name":"Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, Davis, California 95616, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brandon","family":"Pressly","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Medicine, University of California, Davis, Davis, California 95616, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atefeh Mousavi","family":"Nik","sequence":"additional","affiliation":[{"name":"Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, Davis, California 95616, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heike","family":"Wulff","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Medicine, University of California, Davis, Davis, California 95616, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8149-588X","authenticated-orcid":false,"given":"Isaac N","family":"Pessah","sequence":"additional","affiliation":[{"name":"Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, Davis, California 95616, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,1,23]]},"reference":[{"key":"2021111805381582800_kfab007-B1","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1046\/j.1460-9568.1999.00440.x","article-title":"Synaptic and intrinsic mechanisms shape synchronous oscillations in hippocampal neurons in culture","volume":"11","author":"Bacci","year":"1999","journal-title":"Eur. J. Neurosci."},{"key":"2021111805381582800_kfab007-B3","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.neuro.2019.12.001","article-title":"Susceptibility of larval zebrafish to the seizurogenic activity of GABA type A receptor antagonists","volume":"76","author":"Bandara","year":"2020","journal-title":"Neurotoxicology"},{"key":"2021111805381582800_kfab007-B4","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1081\/CLT-120026523","article-title":"Status epilepticus from an illegally imported Chinese rodenticide: \u201ctetramine","volume":"41","author":"Barrueto","year":"2003","journal-title":"J. Toxicol. Clin. Toxicol"},{"key":"2021111805381582800_kfab007-B5","first-page":"199","article-title":"Poisoning by an illegally imported Chinese rodenticide containing tetramethylenedisulfotetramine-New York City, 2002","volume":"52","author":"Barrueto","year":"2003","journal-title":"MMWR Morb. Mortal Wkly. Rep."},{"key":"2021111805381582800_kfab007-B6","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1113\/jphysiol.1989.sp017762","article-title":"Giant synaptic potentials in immature rat CA3 hippocampal neurones","volume":"416","author":"Ben-Ari","year":"1989","journal-title":"J. Physiol"},{"key":"2021111805381582800_kfab007-B7","doi-asserted-by":"crossref","first-page":"e83899","DOI":"10.1371\/journal.pone.0083899","article-title":"The influence of neuronal density and maturation on network activity of hippocampal cell cultures: A methodological study","volume":"8","author":"Biffi","year":"2013","journal-title":"PLoS One"},{"key":"2021111805381582800_kfab007-B8","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1007\/s11064-010-0236-x","article-title":"Primary cultures from cerebral cortex and hippocampus enriched in glutamatergic and GABAergic neurons","volume":"35","author":"Bj\u00f6rklund","year":"2010","journal-title":"Neurochem. Res"},{"key":"2021111805381582800_kfab007-B9","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1093\/toxsci\/kfy029","article-title":"In vitro screening for seizure liability using microelectrode array technology","volume":"163","author":"Bradley","year":"2018","journal-title":"Toxicol. Sci"},{"key":"2021111805381582800_kfab007-B10","doi-asserted-by":"crossref","first-page":"e67","DOI":"10.1002\/cptx.67","article-title":"Screening for neurotoxicity with microelectrode array","volume":"79","author":"Bradley","year":"2019","journal-title":"Curr. Protoc. Toxicol."},{"key":"2021111805381582800_kfab007-B11","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.neuropharm.2015.03.035","article-title":"Combined treatment with diazepam and ALLOP regnanolone reverses tetramethylenedisulfotetramine (TETS)-induced calcium dysregulation in cultured neurons and protects TETS-intoxicated mice against lethal seizures","volume":"95","author":"Bruun","year":"2015","journal-title":"Neuropharmacology"},{"key":"2021111805381582800_kfab007-B12","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1093\/toxsci\/kfs244","article-title":"Tetramethylenedisulfotetramine alters Ca2+ dynamics in cultured hippocampal neurons: Mitigation by NMDA receptor blockade and GABAA receptor-positive modulation","volume":"130","author":"Cao","year":"2012","journal-title":"Toxicol. Sci."},{"key":"2021111805381582800_kfab007-B13","doi-asserted-by":"crossref","first-page":"2923","DOI":"10.1093\/hmg\/dds118","article-title":"Clustered burst firing in FMR1 premutation hippocampal neurons: Amelioration with ALLOP regnanolone","volume":"21","author":"Cao","year":"2012","journal-title":"Hum. Mol. Genet"},{"key":"2021111805381582800_kfab007-B14","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1124\/mol.114.096701","article-title":"Rapid throughput analysis demonstrates that chemicals with distinct seizurogenic mechanisms differentially alter Ca2+ dynamics in networks formed by hippocampal neurons in culture","volume":"87","author":"Cao","year":"2015","journal-title":"Mol. Pharmacol."},{"key":"2021111805381582800_kfab007-B15","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.neuro.2016.10.015","article-title":"Influence of tetramethylenedisulfotetramine on synchronous calcium oscillations at distinct developmental stages of hippocampal neuronal cultures","volume":"58","author":"Cao","year":"2017","journal-title":"Neurotoxicology"},{"key":"2021111805381582800_kfab007-B16","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s00213-013-3276-5","article-title":"Neurosteroid interactions with synaptic and extrasynaptic GABAA receptors: Regulation of subunit plasticity, phasic and tonic inhibition, and neuronal network excitability","volume":"230","author":"Carver","year":"2013","journal-title":"Psychopharmacology"},{"key":"2021111805381582800_kfab007-B17","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1124\/jpet.119.261735","article-title":"Isobolographic analysis of antiseizure activity of the GABA type A receptor-modulating synthetic neurosteroids brexanolone and ganaxolone with tiagabine and midazolam","volume":"372","author":"Chuang","year":"2020","journal-title":"J. Pharmacol. Exp. Ther"},{"key":"2021111805381582800_kfab007-B18","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3389\/fneng.2013.00010","article-title":"Effects of antiepileptic drugs on hippocampal neurons coupled to micro-electrode arrays","volume":"6","author":"Colombi","year":"2013","journal-title":"Front. Neuroeng."},{"key":"2021111805381582800_kfab007-B19","doi-asserted-by":"crossref","first-page":"154","DOI":"10.3389\/fnmol.2019.00154","article-title":"Molecular specialization of GABAergic synapses on the soma and axon in cortical and hippocampal circuit function and dysfunction","volume":"12","author":"Contreras","year":"2019","journal-title":"Front. Mol. Neurosci."},{"year":"2014","author":"Covey","key":"2021111805381582800_kfab007-B20"},{"key":"2021111805381582800_kfab007-B21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00204-003-0509-0","article-title":"Rat poison and food security in the People\u2019s Republic of China: Focus on tetramethylene disulfotetramine (tetramine)","volume":"78","author":"Croddy","year":"2004","journal-title":"Arch. Toxicol."},{"key":"2021111805381582800_kfab007-B22","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1523\/JNEUROSCI.16-01-00130.1996","article-title":"Rise in intracellular calcium via a nongenomic effect of allopregnanolone in fetal rat hypothalamic neurons","volume":"16","author":"Dayanithi","year":"1996","journal-title":"J. Neurosci."},{"key":"2021111805381582800_kfab007-B23","doi-asserted-by":"crossref","first-page":"569361","DOI":"10.3389\/fnins.2020.569361","article-title":"Cell calcium imaging as a reliable method to study neuron-glial circuits","volume":"14","author":"de Melo Reis","year":"2020","journal-title":"Front. Neurosci"},{"key":"2021111805381582800_kfab007-B24","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/bcpt.12778","article-title":"Development of a robust mammalian cell-based assay for studying recombinant \u03b14 \u03b21\/3 \u03b4 GABAA receptor subtypes","volume":"121","author":"Falk-Petersen","year":"2017","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"2021111805381582800_kfab007-B25","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1093\/toxsci\/kfx169","article-title":"Developmental neurotoxicants disrupt activity in cortical networks on microelectrode arrays: Results of screening 86 compounds during neural network formation","volume":"160","author":"Frank","year":"2017","journal-title":"Toxicol. Sci."},{"key":"2021111805381582800_kfab007-B26","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/0014-2999(91)90303-8","article-title":"Neurosteroids block Ca2+ channel current in freshly isolated hippocampal CA1 neurons","volume":"202","author":"French-Mullen","year":"1991","journal-title":"Eur. J. Pharmacol."},{"key":"2021111805381582800_kfab007-B27","doi-asserted-by":"crossref","first-page":"255","DOI":"10.3389\/fncel.2017.00255","article-title":"Early correlated network activity in the hippocampus: Its putative role in shaping neuronal circuits","volume":"11","author":"Griguoli","year":"2017","journal-title":"Front. Cell Neurosci"},{"key":"2021111805381582800_kfab007-B28","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/0922-4106(94)90082-5","article-title":"The neuroactive steroid 3 alpha-hydroxy-5 beta-pregnan-20-one is a two-component modulator of ligand binding to the GABAA receptor","volume":"269","author":"Hawkinson","year":"1994","journal-title":"Eur. J. Pharmacol."},{"key":"2021111805381582800_kfab007-B30","doi-asserted-by":"crossref","first-page":"11495","DOI":"10.1074\/jbc.RA120.013452","article-title":"Photoaffinity labeling identifies an intersubunit steroid-binding site in heteromeric GABA type A (GABAA) receptors","volume":"295","author":"Jayakar","year":"2020","journal-title":"J. Biol. Chem."},{"key":"2021111805381582800_kfab007-B32","first-page":"30751","article-title":"Translational research on chemical nerve agents","author":"Jett","year":"2018","journal-title":"Neurobiol. Dis"},{"key":"2021111805381582800_kfab007-B3070941","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/epi.14482","article-title":"Mechanisms of status epilepticus: \u03b1-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor hypothesis","volume":"59","author":"Joshi","year":"2018","journal-title":"Epilepsia"},{"key":"2021111805381582800_kfab007-B33","doi-asserted-by":"crossref","first-page":"8957","DOI":"10.1523\/JNEUROSCI.2276-07.2007","article-title":"Regulation of neurite growth by spontaneous Ca2+ oscillations in astrocytes","volume":"27","author":"Kanemaru","year":"2007","journal-title":"J. Neurosci."},{"key":"2021111805381582800_kfab007-B34","doi-asserted-by":"crossref","first-page":"2252","DOI":"10.1002\/jnr.22382","article-title":"Regulation of spontaneous Ca2+ spikes by metabotropic glutamate receptors in primary cultures of rat cortical neurons","volume":"88","author":"Koga","year":"2010","journal-title":"J. Neurosci. Res."},{"key":"2021111805381582800_kfab007-B37","doi-asserted-by":"crossref","first-page":"104491","DOI":"10.1016\/j.nbd.2019.104491","article-title":"Tetramethylene-disulfotetramine neurotoxicity: What have we learned in the past 70 years?","volume":"133","author":"Laukov\u00e1","year":"2020","journal-title":"Neurobiol. Dis"},{"key":"2021111805381582800_kfab007-B38","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.toxlet.2019.03.014","article-title":"Mouse model of human poisonings with tetramethylenedisulfotetramine: Characterization of the effect of exposure route on syndrome outcomes","volume":"308","author":"Laukov\u00e1","year":"2019","journal-title":"Toxicol. Lett."},{"key":"2021111805381582800_kfab007-B39","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3389\/fncir.2014.00003","article-title":"The impact of tonic GABAA receptor-mediated inhibition on neuronal excitability varies across brain region and cell type","volume":"8","author":"Lee","year":"2014","journal-title":"Front. Neural Circuits"},{"key":"2021111805381582800_kfab007-B40","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0896-6273(00)80265-2","article-title":"Ca2+ oscillations mediated by the synergistic excitatory actions of GABA(A) and NMDA receptors in the neonatal hippocampus","volume":"18","author":"Leinekugel","year":"1997","journal-title":"Neuron"},{"key":"2021111805381582800_kfab007-B41","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1186\/1471-2458-14-842","article-title":"Tetramine poisoning in China: Changes over a decade viewed through the media\u2019s eye","volume":"14","author":"Li","year":"2014","journal-title":"BMC Public Health"},{"key":"2021111805381582800_kfab007-B42","doi-asserted-by":"crossref","first-page":"8410","DOI":"10.3390\/ijms21218410","article-title":"Ketamine and calcium signaling-A crosstalk for neuronal physiology and pathology","volume":"21","author":"Lisek","year":"2020","journal-title":"Int. J. Mol. Sci"},{"key":"2021111805381582800_kfab007-B43","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.yebeh.2015.02.027","article-title":"Single versus combinatorial therapies in status epilepticus: Novel data from preclinical models","volume":"49","author":"L\u00f6scher","year":"2015","journal-title":"Epilepsy Behav."},{"key":"2021111805381582800_kfab007-B44","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1002\/epi4.12344","article-title":"Neurosteroid and benzodiazepine combination therapy reduces status epilepticus and long-term effects of whole-body sarin exposure in rats","volume":"4","author":"Lumley","year":"2019","journal-title":"Epilepsia Open"},{"key":"2021111805381582800_kfab007-B45","doi-asserted-by":"crossref","first-page":"186","DOI":"10.3389\/fncir.2013.00186","article-title":"Distinct roles of synaptic and extrasynaptic GABAAreceptors in striatal inhibition dynamics","volume":"7","author":"Luo","year":"2013","journal-title":"Front. Neural Circuits"},{"key":"2021111805381582800_kfab007-B46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2015\/196195","article-title":"In vitro studies of neuronal networks and synaptic plasticity in invertebrates and in mammals using multielectrode arrays","volume":"2015","author":"Massobrio","year":"2015","journal-title":"Neural Plast."},{"key":"2021111805381582800_kfab007-B47","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1016\/j.neuro.2012.05.001","article-title":"Evaluation of multi-well microelectrode arrays for neurotoxicity screening using a chemical training set","volume":"33","author":"McConnell","year":"2012","journal-title":"Neurotoxicology"},{"key":"2021111805381582800_kfab007-B48","doi-asserted-by":"crossref","first-page":"100795","DOI":"10.1016\/j.yfrne.2019.100795","article-title":"Neurosteroids and neuropathic pain management: Basic evidence and therapeutic perspectives","volume":"55","author":"Meyer","year":"2019","journal-title":"Front. Neuroendocrinol"},{"issue":"Pt 6","key":"2021111805381582800_kfab007-B49","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1042\/BST0371317","article-title":"Neuronal glutamate and GABAA receptor function in health and disease","volume":"37","author":"Moult","year":"2009","journal-title":"Biochem. Soc. Trans."},{"key":"2021111805381582800_kfab007-B50","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1124\/mol.117.108563","article-title":"Rapid throughput analysis of GABAA receptor subtype modulators and blockers using DiSBAC1(3) membrane potential red dye","volume":"92","author":"Nik","year":"2017","journal-title":"Mol. Pharmacol."},{"key":"2021111805381582800_kfab007-B51","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1002\/glia.23747","article-title":"Role of astrocyte purinergic signaling in epilepsy","volume":"68","author":"Nikolic","year":"2020","journal-title":"Glia"},{"key":"2021111805381582800_kfab007-B52","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1111\/nyas.13147","article-title":"Benzodiazepine-refractory status epilepticus: Pathophysiology and principles of treatment","volume":"1378","author":"Niquet","year":"2016","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"2021111805381582800_kfab007-B53","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1093\/acprof:oso\/9780198745273.003.0007","volume-title":"Dendrites","author":"Nusser","year":"2016","edition":"3rd ed"},{"key":"2021111805381582800_kfab007-B55","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.neuropharm.2018.01.036","article-title":"GABAA receptor: Positive and negative allosteric modulators","volume":"136","author":"Olsen","year":"2018","journal-title":"Neuropharmacology"},{"key":"2021111805381582800_kfab007-B56","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.cbpa.2020.07.006","article-title":"Imaging voltage and brain chemistry with genetically encoded sensors and modulators","volume":"57","author":"Pal","year":"2020","journal-title":"Curr. Opin. Chem. Biol"},{"key":"2021111805381582800_kfab007-B2574190","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.pain.2005.01.009","article-title":"New evidence that both T-type calcium channels and GABAA channels are responsible for the potent peripheral analgesic effects of 5alpha-reduced neuroactive steroids","volume":"114","author":"Pathirathna","year":"2005","journal-title":"Pain"},{"key":"2021111805381582800_kfab007-B57","doi-asserted-by":"crossref","first-page":"51","DOI":"10.3390\/toxics6030051","article-title":"Tetramethylenedisulfotetramine: A health risk compound and a potential chemical warfare agent","volume":"6","author":"Patocka","year":"2018","journal-title":"Toxics"},{"key":"2021111805381582800_kfab007-B58","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1111\/nyas.13137","article-title":"Models to identify treatments for the acute and persistent effects of seizure-inducing chemical threat agents","volume":"1378","author":"Pessah","year":"2016","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"2021111805381582800_kfab007-B59","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1039\/c5ib00285k","article-title":"Studying complex system: Calcium oscillations as attractor of cell differentiation","volume":"8","author":"Pinto","year":"2016","journal-title":"Integr. Biol. (Camb.)"},{"key":"2021111805381582800_kfab007-B60","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1007\/s00204-020-02728-z","article-title":"Comparison of the toxicokinetics of the convulsants picrotoxinin and tetramethylenedisulfo-tetramine (TETS) in mice","volume":"94","author":"Pressly","year":"2020","journal-title":"Arch. Toxicol"},{"key":"2021111805381582800_kfab007-B61","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1007\/s00204-017-2089-4","article-title":"GABAA receptor subtype selectivity of the proconvulsant rodenticide TETS","volume":"92","author":"Pressly","year":"2018","journal-title":"Arch. Toxicol."},{"key":"2021111805381582800_kfab007-B62","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.tips.2016.04.003","article-title":"Clinical potential of neurosteroids for CNS disorders","volume":"37","author":"Reddy","year":"2016","journal-title":"Trends Pharmacol. Sci"},{"key":"2021111805381582800_kfab007-B1498399","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/nrd3502","article-title":"Beyond classical benzodiazepines: novel therapeutic potential of GABAA receptor subtypes","volume":"10","author":"Rudolph","year":"2011","journal-title":"Nat. Rev. Drug Discov."},{"key":"2021111805381582800_kfab007-B64","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/s41583-020-0361-8","article-title":"Making sense of astrocytic calcium signals - From acquisition to interpretation","volume":"21","author":"Semyanov","year":"2020","journal-title":"Nat. Rev. Neurosci"},{"key":"2021111805381582800_kfab007-B65","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.neuro.2015.03.007","article-title":"Combined diazepam and MK-801 therapy provides synergistic protection from tetramethylenedisulfotetramine-induced tonic-clonic seizures and lethality in mice","volume":"48","author":"Shakarjian","year":"2015","journal-title":"Neurotoxicology"},{"key":"2021111805381582800_kfab007-B66","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.ceca.2018.09.002","article-title":"Calmodulin-binding proteins: A journey of 40 years","volume":"75","author":"Sharma","year":"2018","journal-title":"Cell Calcium"},{"key":"2021111805381582800_kfab007-B67","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1016\/j.bbagen.2013.11.015","article-title":"Frequency decoding of calcium oscillations","volume":"1840","author":"Smedler","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"2021111805381582800_kfab007-B68","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.ceb.2020.01.010","article-title":"Endoplasmic reticulum-plasma membrane contacts: Principals of phosphoinositide and calcium signaling","volume":"63","author":"Stefan","year":"2020","journal-title":"Curr. Opin. Cell Biol"},{"key":"2021111805381582800_kfab007-B69","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1523\/JNEUROSCI.23-03-00927.2003","article-title":"Spontaneous calcium transients in developing cortical neurons regulate axon outgrowth","volume":"23","author":"Tang","year":"2003","journal-title":"J. Neurosci."},{"key":"2021111805381582800_kfab007-B70","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.neuro.2018.06.007","article-title":"Human iPSC-derived neuronal models for in vitro neurotoxicity assessment","volume":"67","author":"Tukker","year":"2018","journal-title":"Neurotoxicology"},{"key":"2021111805381582800_kfab007-B71","first-page":"17","article-title":"Temporal coding at the immature depolarizing GABAergic synapse","volume":"4","author":"Valeeva","year":"2010","journal-title":"Front. Cell Neurosci"},{"key":"2021111805381582800_kfab007-B73","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.1186\/1471-2202-9-S2-S11","article-title":"Allopregnanolone-induced rise in intracellular calcium in embryonic hippocampal neurons parallels their proliferative potential","volume":"9","author":"Wang","year":"2008","journal-title":"BMC Neurosci"},{"key":"2021111805381582800_kfab007-B74","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.annemergmed.2004.09.009","article-title":"Tetramethylenedisulfotetramine: old agent and new terror","volume":"45","author":"Whitlow","year":"2005","journal-title":"Ann. Emerg. Med."},{"key":"2021111805381582800_kfab007-B76","doi-asserted-by":"crossref","first-page":"e24","DOI":"10.1016\/j.forsciint.2010.06.025","article-title":"Tetramine poisoning: A case report and review of the literature","volume":"204","author":"Zhang","year":"2011","journal-title":"Forensic Sci. Int."},{"key":"2021111805381582800_kfab007-B77","doi-asserted-by":"crossref","first-page":"8607","DOI":"10.1073\/pnas.1407379111","article-title":"GABAA receptor target of tetramethylenedisulfotetramine","volume":"111","author":"Zhao","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2021111805381582800_kfab007-B78","first-page":"37","article-title":"The study of status and advances on tetramine poisoning","volume":"20","author":"Zhu","year":"2004","journal-title":"Fa Yi Xue Za Zhi"},{"key":"2021111805381582800_kfab007-B79","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1124\/jpet.111.190579","article-title":"Characterization of seizures induced by acute and repeated exposure to tetramethylenedisulfotetramine","volume":"341","author":"Zolkowska","year":"2012","journal-title":"J. Pharmacol. Exp. Ther"},{"key":"2021111805381582800_kfab007-B80","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1111\/epi.13999","article-title":"Intramuscular allopregnanolone and ganaxolone in a mouse model of treatment-resistant status epilepticus","volume":"59","author":"Zolkowska","year":"2018","journal-title":"Epilepsia"}],"container-title":["Toxicological Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/toxsci\/advance-article-pdf\/doi\/10.1093\/toxsci\/kfab007\/36253300\/kfab007.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/toxsci\/article-pdf\/180\/2\/325\/41163221\/kfab007.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/toxsci\/article-pdf\/180\/2\/325\/41163221\/kfab007.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T08:45:51Z","timestamp":1637225151000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/toxsci\/article\/180\/2\/325\/6112026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,23]]},"references-count":74,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2021,1,23]]},"published-print":{"date-parts":[[2021,4,12]]}},"URL":"https:\/\/doi.org\/10.1093\/toxsci\/kfab007","relation":{},"ISSN":["1096-6080","1096-0929"],"issn-type":[{"type":"print","value":"1096-6080"},{"type":"electronic","value":"1096-0929"}],"subject":[],"published-other":{"date-parts":[[2021,4,1]]},"published":{"date-parts":[[2021,1,23]]}}}