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Of the currently known epitranscriptomic modifications, N6-methyladenosine (m6A) methylation is the most abundant. The m6A modification is predominantly regulated by 3 tiers of protein modulators classified as writers, erasers, and readers. Depending upon cellular needs, these proteins function to deposit, remove, or read the methyl modifications on cognate mRNAs. Many environmental chemicals including heavy metals, pesticides, and other toxic pollutants, are all known to perturb transcription and translation machinery to exert their toxic responses. As such, we herein review how the m6A modification may be affected under different toxicological paradigms. Furthermore, we discuss how toxicants can affect the 3 tiers of regulation directly, and how these effects influence the m6A-modified mRNAs. Lastly, we highlight the disparities between published findings and theories, especially those concerning the m6A reader tier of regulation. In the far-reaching field of toxicology, m6A epitranscriptomics provides another enticing avenue to explore new mechanisms and therapies for a diverse range of environmentally linked disorders and diseases.<\/jats:p>","DOI":"10.1093\/toxsci\/kfab021","type":"journal-article","created":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T13:48:47Z","timestamp":1613656127000},"page":"13-22","source":"Crossref","is-referenced-by-count":35,"title":["Emerging Roles of N6-Methyladenosine (m6A) Epitranscriptomics in Toxicology"],"prefix":"10.1093","volume":"181","author":[{"given":"Emir","family":"Malovic","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, Parkinson\u2019s Disorder Research Program, Iowa State University, Ames, Iowa 50011"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyssa","family":"Ealy","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Parkinson\u2019s Disorder Research Program, Iowa State University, Ames, Iowa 50011"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthi","family":"Kanthasamy","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Parkinson\u2019s Disorder Research Program, Iowa State University, Ames, Iowa 50011"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anumantha G","family":"Kanthasamy","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Parkinson\u2019s Disorder Research Program, Iowa State University, Ames, Iowa 50011"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,2,22]]},"reference":[{"key":"2022051715443149200_kfab021-B1","doi-asserted-by":"crossref","first-page":"4741","DOI":"10.1093\/nar\/gku085","article-title":"Structure of human RNA N(6)-methyladenine demethylase ALKBH5 provides insights into its mechanisms of nucleic acid recognition and demethylation","volume":"42","author":"Aik","year":"2014","journal-title":"Nucleic Acids Res"},{"key":"2022051715443149200_kfab021-B2","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1007\/s00109-016-1439-7","article-title":"Differential transcriptional regulation of hypoxia-inducible factor-1alpha by arsenite under normoxia and hypoxia: Involvement of Nrf2","volume":"94","author":"Al Taleb","year":"2016","journal-title":"J. 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