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The cardiometabolic effects of BPF in either humans or model organisms are not clear, and no studies to date have investigated the role of genetic background on susceptibility to BPF-induced cardiometabolic traits. The primary goal of this project was to determine if BPF exposure influences growth and adiposity in male N:NIH heterogeneous stock (HS) rats, a genetically heterogeneous population. Littermate pairs of male HS rats were randomly exposed to either vehicle (0.1% ethanol) or 1.125\u2009\u00b5g\/ml BPF in 0.1% ethanol for 5 weeks in drinking water starting at 3 weeks-of-age. Water consumption and body weight was measured weekly, body composition was determined using nuclear magnetic resonance, urine and feces were collected in metabolic cages, and blood and tissues were collected at the end of the study. BPF-exposed rats showed significantly increased body growth and abdominal adiposity, risk factors for cardiometabolic disease. Urine output was increased in BPF-exposed rats, driving a trend in increased creatinine clearance. We also report the first relationship between a bisphenol metabolizing enzyme and a bisphenol-induced phenotype. Preliminary heritability estimates of significant phenotypes suggest that BPF exposure may alter trait variation. These findings support BPF exposure as a cardiometabolic disease risk factor and indicate that the HS rat will be a useful model for dissecting gene by BPF interactions on metabolic health.<\/jats:p>","DOI":"10.1093\/toxsci\/kfab035","type":"journal-article","created":{"date-parts":[[2021,3,22]],"date-time":"2021-03-22T20:13:51Z","timestamp":1616444031000},"page":"246-261","source":"Crossref","is-referenced-by-count":12,"title":["Bisphenol F Exposure in Adolescent Heterogeneous Stock Rats Affects Growth and Adiposity"],"prefix":"10.1093","volume":"181","author":[{"given":"Valerie A","family":"Wagner","sequence":"first","affiliation":[{"name":"Department of Pharmacology, University of Iowa, Iowa City, Iowa 52242, USA"},{"name":"Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen C","family":"Clark","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, University of Iowa, Iowa City, Iowa 52242, USA"},{"name":"Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leslie","family":"Carrillo-S\u00e1enz","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Metabolism and Department of Physiology and Biophysics, University of Illinois at Chicago College of Medicine, Chicago, Illinois 60612, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katie A","family":"Holl","sequence":"additional","affiliation":[{"name":"Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miriam","family":"Velez-Bermudez","sequence":"additional","affiliation":[{"name":"Department of Psychological & Brain Sciences, University of Iowa, Iowa City, Iowa 52242, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Derek","family":"Simonsen","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health, University of Iowa, Iowa City, Iowa 52242, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin L","family":"Grobe","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, University of Iowa, Iowa City, Iowa 52242, USA"},{"name":"Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA"},{"name":"Department of Biomedical Engineering, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA"},{"name":"Comprehensive Rodent Metabolic Phenotyping Core, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, University of Iowa, Iowa City, Iowa 52242, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Thurman","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Iowa, Iowa City, Iowa 52242, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leah C","family":"Solberg Woods","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina 27101, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9163-927X","authenticated-orcid":false,"given":"Hans-Joachim","family":"Lehmler","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health, University of Iowa, Iowa City, Iowa 52242, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1024-4116","authenticated-orcid":false,"given":"Anne E","family":"Kwitek","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, University of Iowa, Iowa City, Iowa 52242, USA"},{"name":"Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA"},{"name":"Rat Genome Database, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,3,23]]},"reference":[{"key":"2021070800212145900_kfab035-B1","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/j.1600-0722.2004.00136.x","article-title":"Leached components from dental composites and their effects on fertility of female mice","volume":"112","author":"Al-Hiyasat","year":"2004","journal-title":"Eur. 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