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The future prevalence of DILI can be minimized by developing a greater understanding of the biological mechanisms behind DILI. Both qualitative and quantitative analytical techniques are vital to characterizing and investigating DILI. In vitro assays are capable of characterizing specific aspects of a drug\u2019s hepatotoxic nature and multiplexed assays are capable of characterizing and scoring a drug\u2019s association with DILI. However, an even deeper insight into the perturbations to biological pathways involved in the mechanisms of DILI can be gained through the use of omics-based analytical techniques: genomics, transcriptomics, proteomics, and metabolomics. These omics analytical techniques can offer qualitative and quantitative insight into genetic susceptibilities to DILI, the impact of drug treatment on gene expression, and the effect on protein and metabolite abundance. This review will discuss the analytical techniques that can be applied to characterize and investigate the biological mechanisms of DILI and potential predictive biomarkers.<\/jats:p>","DOI":"10.1093\/toxsci\/kfab069","type":"journal-article","created":{"date-parts":[[2021,6,3]],"date-time":"2021-06-03T16:17:31Z","timestamp":1622737051000},"page":"1-13","source":"Crossref","is-referenced-by-count":36,"title":["Analytical and Omics-Based Advances in the Study of Drug-Induced Liver Injury"],"prefix":"10.1093","volume":"183","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6534-4638","authenticated-orcid":false,"given":"Thomas","family":"Kralj","sequence":"first","affiliation":[{"name":"Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1945-4929","authenticated-orcid":false,"given":"Kim L R","family":"Brouwer","sequence":"additional","affiliation":[{"name":"Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7569, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7497-7082","authenticated-orcid":false,"given":"Darren J","family":"Creek","sequence":"additional","affiliation":[{"name":"Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,6,4]]},"reference":[{"key":"2021101015225708900_kfab069-B1","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1097\/00008571-199610000-00006","article-title":"Identification and prevalence study of 17 allelic variants of the human NAT2 gene in a white population","volume":"6","author":"Ag\u00fandez","year":"1996","journal-title":"Pharmacogenetics (Lond.)"},{"key":"2021101015225708900_kfab069-B2","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1002\/hep.20205","article-title":"Hepatic adducts, circulating antibodies, and cytokine polymorphisms in patients with diclofenac hepatotoxicity","volume":"39","author":"Aithal","year":"2004","journal-title":"Hepatology"},{"key":"2021101015225708900_kfab069-B3","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1002\/hep.20215","article-title":"HLA class II genotype influences the type of liver injury in drug-induced idiosyncratic liver disease","volume":"39","author":"Andrade","year":"2004","journal-title":"Hepatology"},{"key":"2021101015225708900_kfab069-B4","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.2217\/pgs.09.111","article-title":"Drug-induced liver injury: Insights from genetic studies","volume":"10","author":"Andrade","year":"2009","journal-title":"Pharmacogenomics"},{"key":"2021101015225708900_kfab069-B5","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1002\/hep.24290","article-title":"Induction of vesicular steatosis by amiodarone and tetracycline is associated with up-regulation of lipogenic genes in HepaRG cells","volume":"53","author":"Antherieu","year":"2011","journal-title":"Hepatology"},{"key":"2021101015225708900_kfab069-B6","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/nature15816","article-title":"Building the foundation for genomics in precision medicine","volume":"526","author":"Aronson","year":"2015","journal-title":"Nature"},{"key":"2021101015225708900_kfab069-B7","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1053\/j.gastro.2013.02.006","article-title":"Incidence, presentation, and outcomes in patients with drug-induced liver injury in the general population of Iceland","volume":"144","author":"Bjornsson","year":"2013","journal-title":"Gastroenterology"},{"key":"2021101015225708900_kfab069-B8","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1002\/hep.23647","article-title":"Inhibition of mitochondrial function by efavirenz increases lipid content in hepatic cells","volume":"52","author":"Blas-Garc\u00eda","year":"2010","journal-title":"Hepatology"},{"key":"2021101015225708900_kfab069-B9","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1053\/j.gastro.2008.09.011","article-title":"Causes, clinical features, and outcomes from a prospective study of drug-induced liver injury in the United States","volume":"135","author":"Chalasani","year":"2008","journal-title":"Gastroenterology"},{"key":"2021101015225708900_kfab069-B11","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1093\/toxsci\/kfx284","article-title":"Measures of BSEP inhibition in vitro are not useful predictors of DILI","volume":"162","author":"Chan","year":"2018","journal-title":"Toxicol. 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