{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:35:54Z","timestamp":1790642154550,"version":"4.1.0"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2021,6,4]],"date-time":"2021-06-04T00:00:00Z","timestamp":1622764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"The Danish Council for Independent Research","award":["DFF-6110-00103"],"award-info":[{"award-number":["DFF-6110-00103"]}]},{"name":"FFIKA"},{"name":"Danish Government"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,8,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Carbon nanotubes (CNTs) are speculated to cause mesothelioma by persistent inflammation, oxidative stress, tissue injury, and genotoxicity. To investigate the pleural response to CNTs, we exposed C57BL\/6 mice by intrapleural injection of 0.2 or 5\u2009\u00b5g multiwalled CNTs (MWCNT-7, NM-401, and NM-403) or single-walled CNTs (NM-411). Inflammatory response, cellular reactive oxygen species (ROS) production of pleural lavage cells, and genotoxicity in cells from the mesothelial surface were assessed at days 1 and 90 after the exposure. Long and rigid types of MWCNTs (MWCNT-7 and NM-401) caused acute inflammation, characterized by influx of macrophages, neutrophils, and eosinophils into the pleural cavity. The inflammation was still evident at 90\u2009days after the exposure, although it had reduced dramatically. The cellular ROS production was increased at day 90 after the exposure to MWCNT-7 and NM-401. The short and tangled type of MWCNT (ie NM-403) did not cause pleural inflammation or ROS production in pleural fluid cells. The exposure to NM-411 did not cause consistent inflammation responses or cellular ROS production. Levels of DNA strand breaks and DNA oxidation damage were unaltered, except for NM-411-exposed mice that had increased levels of DNA strand breaks at 90\u2009days after the exposure. In conclusion, the long and rigid CNTs caused prolonged inflammatory response and increased ROS production in pleural lavage cells, yet it was not reflected in higher levels of DNA damage in pleural tissue.<\/jats:p>","DOI":"10.1093\/toxsci\/kfab070","type":"journal-article","created":{"date-parts":[[2021,6,3]],"date-time":"2021-06-03T08:36:03Z","timestamp":1622709363000},"page":"184-194","source":"Crossref","is-referenced-by-count":20,"title":["Inflammatory Response, Reactive Oxygen Species Production and DNA Damage in Mice After Intrapleural Exposure to Carbon Nanotubes"],"prefix":"10.1093","volume":"183","author":[{"given":"Regitze S\u00f8lling","family":"Wils","sequence":"first","affiliation":[{"name":"Department of Public Health, Section of Environmental Health, University of Copenhagen, DK-1014 Copenhagen K, Denmark"},{"name":"The National Research Centre for the Working Environment, DK-2100 Copenhagen \u00d8, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2504-2229","authenticated-orcid":false,"given":"Nicklas Raun","family":"Jacobsen","sequence":"additional","affiliation":[{"name":"The National Research Centre for the Working Environment, DK-2100 Copenhagen \u00d8, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6807-1524","authenticated-orcid":false,"given":"Ulla","family":"Vogel","sequence":"additional","affiliation":[{"name":"The National Research Centre for the Working Environment, DK-2100 Copenhagen \u00d8, Denmark"},{"name":"Department of Health Tech, Technical University of Denmark, DK-2800, Lyngby, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7206-0032","authenticated-orcid":false,"given":"Martin","family":"Roursgaard","sequence":"additional","affiliation":[{"name":"Department of Public Health, Section of Environmental Health, University of Copenhagen, DK-1014 Copenhagen K, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2021-1249","authenticated-orcid":false,"given":"Peter","family":"M\u00f8ller","sequence":"additional","affiliation":[{"name":"Department of Public Health, Section of Environmental Health, University of Copenhagen, DK-1014 Copenhagen K, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,6,4]]},"reference":[{"key":"2021083017310663800_kfab070-B2","doi-asserted-by":"crossref","first-page":"2721","DOI":"10.1002\/smll.201202508","article-title":"Biodegradation of single-walled carbon nanotubes by eosinophil peroxidase","volume":"9","author":"And\u00f3n","year":"2013","journal-title":"Small"},{"key":"2021083017310663800_kfab070-B4","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1080\/17435390.2018.1465139","article-title":"Inflammation in the pleural cavity following injection of multi-walled carbon nanotubes is dependent on their characteristics and the presence of IL-1 genes","volume":"12","author":"Arnoldussen","year":"2018","journal-title":"Nanotoxicology"},{"key":"2021083017310663800_kfab070-B5","doi-asserted-by":"crossref","first-page":"3302","DOI":"10.1016\/j.cub.2017.09.007","article-title":"Long-fiber carbon nanotubes replicate asbestos-induced mesothelioma with disruption of the tumor suppressor gene Cdkn2a (Ink4a\/Arf)","volume":"27","author":"Chernova","year":"2017","journal-title":"Curr. 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