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Great efforts have been made to develop physiologically based pharmacokinetic (PBPK) models for estimating withdrawal intervals (WDIs) for extralabel prescribed drugs in food animals. Existing models are insufficient to address the food safety concern as these models are either limited to 1 specific drug or difficult to be used by non-modelers. This study aimed to develop a user-friendly generic PBPK platform that can predict tissue residues and estimate WDIs for multiple drugs including flunixin, florfenicol, and penicillin G in cattle and swine. Mechanism-based in silico methods were used to predict tissue\/plasma partition coefficients and the models were calibrated and evaluated with pharmacokinetic data from Food Animal Residue Avoidance Databank (FARAD). Results showed that model predictions were, in general, within a 2-fold factor of experimental data for all 3 drugs in both species. Following extralabel administration and respective U.S. FDA-approved tolerances, predicted WDIs for both cattle and swine were close to or slightly longer than FDA-approved label withdrawal times (eg, predicted 8, 28, and 7\u2009days vs labeled 4, 28, and 4\u2009days for flunixin, florfenicol, and penicillin G in cattle, respectively). The final model was converted to a web-based interactive generic PBPK platform. This PBPK platform serves as a user-friendly quantitative tool for real-time predictions of WDIs for flunixin, florfenicol, and penicillin G following FDA-approved label or extralabel use in both cattle and swine, and provides a basis for extrapolating to other drugs and species.<\/jats:p>","DOI":"10.1093\/toxsci\/kfac056","type":"journal-article","created":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T12:24:32Z","timestamp":1654086272000},"page":"180-197","source":"Crossref","is-referenced-by-count":24,"title":["An Interactive Generic Physiologically Based Pharmacokinetic (igPBPK) Modeling Platform to Predict Drug Withdrawal Intervals in Cattle and Swine: A Case Study on Flunixin, Florfenicol, and Penicillin G"],"prefix":"10.1093","volume":"188","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3355-6921","authenticated-orcid":false,"given":"Wei-Chun","family":"Chou","sequence":"first","affiliation":[{"name":"Department of Environmental and Global Health, College of Public Health and Health Professions, University of Florida , Gainesville, Florida 32610, USA"},{"name":"Center for Environmental and Human Toxicology, University of Florida , Florida 32608, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa A","family":"Tell","sequence":"additional","affiliation":[{"name":"Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California-Davis , Davis, California 95616, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald E","family":"Baynes","sequence":"additional","affiliation":[{"name":"Center for Chemical Toxicology Research and Pharmacokinetics, Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University , Raleigh, North Carolina 27606, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7930-4589","authenticated-orcid":false,"given":"Jennifer L","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine , Blacksburg, Virginia 24060, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fiona P","family":"Maunsell","sequence":"additional","affiliation":[{"name":"Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida , Gainesville, Florida 32608, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jim E","family":"Riviere","sequence":"additional","affiliation":[{"name":"Center for Chemical Toxicology Research and Pharmacokinetics, Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University , Raleigh, North Carolina 27606, USA"},{"name":"1Data Consortium, Kansas State University , Olathe, Kansas 66061, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8731-8366","authenticated-orcid":false,"given":"Zhoumeng","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Environmental and Global Health, College of Public Health and Health Professions, University of Florida , Gainesville, Florida 32610, USA"},{"name":"Center for Environmental and Human Toxicology, University of Florida , Florida 32608, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,6,1]]},"reference":[{"key":"2022072818185334400_kfac056-B1","first-page":"1725","article-title":"Tissue concentrations and pharmacokinetics of florfenicol in male veal calves given repeated doses","volume":"48","author":"Adams","year":"1987","journal-title":"Am. 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