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Therefore, this study aimed to investigate the impact that stress, associated or not with sertraline, causes on the reproductive development of male rats. Pregnant Wistar rats were divided into 4 groups (n\u2009=\u200916\/group): CO\u2014received filtered water; SE\u2014received 20\u2009mg\/kg sertraline; ST\u2014submitted to restraint stress and received filtered water; SS\u2014submitted to restraint stress and received sertraline. The treatment was carried out from gestational days (GDs) 13\u201320. The animals were euthanized on GD 20 (n\u2009=\u20098\/group), postnatal day (PND) 45 (n\u2009=\u20098\/group), and PND 110 (n\u2009=\u20098\/group). The testes and epididymis were analyzed histologically, and immunohistochemistry was performed on the testes by proliferating cell nuclear antigen (PCNA) and the Wilms tumor protein (Wt1). Sperm quality was also analyzed on PND 110. The evolution of body weight, anogenital distance (AGD), and puberty installation day were also verified. Statistical analysis: 2-way ANOVA or Kruskal-Wallis test (p\u2009\u2264\u2009.05). Fetal testes presented a large number of acidophilic cells in the sertraline-exposed groups. The SS group also showed a decrease in the nuclear volume of Leydig cells. This same group showed low expression of PCNA and Wt1, decreased weight of the testes and epididymis, lower AGD, and delayed puberty installation. The adulthood groups exposed to sertraline presented alterations in sperm morphology and motility. The results demonstrated that prenatal exposure to sertraline compromises the development of the rat reproductive system.<\/jats:p>","DOI":"10.1093\/toxsci\/kfac100","type":"journal-article","created":{"date-parts":[[2022,9,26]],"date-time":"2022-09-26T13:31:00Z","timestamp":1664199060000},"page":"189-203","source":"Crossref","is-referenced-by-count":7,"title":["Reproductive Development of Male Rats Exposed <i>In Utero<\/i> to Stress and\/or Sertraline"],"prefix":"10.1093","volume":"190","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2828-7544","authenticated-orcid":false,"given":"Ana Fl\u00e1via","family":"Quiarato Lozano","sequence":"first","affiliation":[{"name":"Laboratory of Reproductive and Developmental Biology and Toxicology, Department of Structural and Functional Biology, Institute of Biosciences, S\u00e3o Paulo State University (UNESP) , Botucatu, SP 18618-689, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruna","family":"Marques Tavares","sequence":"additional","affiliation":[{"name":"Laboratory of Reproductive and Developmental Biology and Toxicology, Department of Structural and Functional Biology, Institute of Biosciences, S\u00e3o Paulo State University (UNESP) , Botucatu, SP 18618-689, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patr\u00edcia","family":"Villela e Silva","sequence":"additional","affiliation":[{"name":"Laboratory of Reproductive and Developmental Biology and Toxicology, Department of Structural and Functional Biology, Institute of Biosciences, S\u00e3o Paulo State University (UNESP) , Botucatu, SP 18618-689, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge Willian","family":"Franco de Barros","sequence":"additional","affiliation":[{"name":"Laboratory of Reproductive and Developmental Biology and Toxicology, Department of Structural and Functional Biology, Institute of Biosciences, S\u00e3o Paulo State University (UNESP) , Botucatu, SP 18618-689, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2112-5123","authenticated-orcid":false,"given":"Wilma","family":"De Grava Kempinas","sequence":"additional","affiliation":[{"name":"Laboratory of Reproductive and Developmental Biology and Toxicology, Department of Structural and Functional Biology, Institute of Biosciences, S\u00e3o Paulo State University (UNESP) , Botucatu, SP 18618-689, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,9,26]]},"reference":[{"key":"2022112808000239200_kfac100-B1","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1016\/j.urology.2013.12.004","article-title":"Comparison of the effect of sertraline with behavioral therapy on semen parameters in men with primary premature ejaculation","volume":"83","author":"Akasheh","year":"2014","journal-title":"Urology"},{"key":"2022112808000239200_kfac100-B2","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.euroneuro.2009.06.003","article-title":"Proapoptotic and chemosensitizing effects of selective serotonin reuptake inhibitors on T cell lymphoma\/leukemia (Jurkat) in vitro","volume":"19","author":"Amit","year":"2009","journal-title":"Eur. 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