{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T02:03:58Z","timestamp":1792461838309,"version":"4.5.0"},"reference-count":92,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5K01TW010828-04"],"award-info":[{"award-number":["5K01TW010828-04"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Duke University Provost\u2019s Collaboratories Fund"},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32ES021432"],"award-info":[{"award-number":["T32ES021432"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Duke University Program in Environmental Health"},{"name":"Duke Department of Obstetrics and Gynecology"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,2,17]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Perfluorobutanesulfonic acid (PFBS) is a replacement for perfluorooctanesulfonic acid (PFOS) that is increasingly detected in drinking water and human serum. Higher PFBS exposure is associated with risk for preeclampsia, the leading cause of maternal and infant morbidity and mortality in the United States. This study investigated relevant maternal and fetal health outcomes after gestational exposure to PFBS in a New Zealand White rabbit model. Nulliparous female rabbits were supplied drinking water containing 0\u2009mg\/l (control), 10\u2009mg\/l (low), or 100\u2009mg\/l (high) PFBS. Maternal blood pressure, body weights, liver and kidney weights histopathology, clinical chemistry panels, and thyroid hormone levels were evaluated. Fetal endpoints evaluated at necropsy included viability, body weights, crown-rump length, and liver and kidney histopathology, whereas placenta endpoints included weight, morphology, histopathology, and full transcriptome RNA sequencing. PFBS-high dose dams exhibited significant changes in blood pressure markers, seen through increased pulse pressure and renal resistive index measures, as well as kidney histopathological changes. Fetuses from these dams showed decreased crown-rump length. Statistical analysis of placental weight via a mixed model statistical approach identified a significant interaction term between PFBS high dose and fetal sex, suggesting a sex-specific effect on placental weight. RNA sequencing identified the dysregulation of angiotensin (AGT) in PFBS high-dose placentas. These results suggest that PFBS exposure during gestation leads to adverse maternal outcomes, such as renal injury and hypertension, and fetal outcomes, including decreased growth parameters and adverse placenta function. These outcomes raise concerns about pregnant women\u2019s exposure to PFBS and pregnancy outcomes.<\/jats:p>","DOI":"10.1093\/toxsci\/kfac126","type":"journal-article","created":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T17:50:33Z","timestamp":1669917033000},"page":"239-252","source":"Crossref","is-referenced-by-count":32,"title":["Maternal exposure to perfluorobutane sulfonate (PFBS) during pregnancy: evidence of adverse maternal and fetoplacental effects in New Zealand White (NZW) rabbits"],"prefix":"10.1093","volume":"191","author":[{"given":"Christine E","family":"Crute","sequence":"first","affiliation":[{"name":"Integrated Toxicology and Environmental Health Program, Nicholas School of the Environment, Duke University , Durham, North Carolina 27710, USA"},{"name":"Nicholas School of the Environment, Duke University , Durham, North Carolina 27710, USA"},{"name":"Department of Obstetrics and Gynecology, Duke University School of Medicine , Durham, North Carolina 27710, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chelsea D","family":"Landon","sequence":"additional","affiliation":[{"name":"Division of Laboratory Animal Resources, Duke University Medical Center , Durham, North Carolina 27710, USA"},{"name":"Department of Pathology, Duke University School of Medicine, Duke University , Durham, North Carolina 27710, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Garner","sequence":"additional","affiliation":[{"name":"Department of Pathology, Duke University School of Medicine, Duke University , Durham, North Carolina 27710, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1608-9508","authenticated-orcid":false,"given":"Samantha M","family":"Hall","sequence":"additional","affiliation":[{"name":"Integrated Toxicology and Environmental Health Program, Nicholas School of the Environment, Duke University , Durham, North Carolina 27710, USA"},{"name":"Nicholas School of the Environment, Duke University , Durham, North Carolina 27710, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0273-6284","authenticated-orcid":false,"given":"Jeffery I","family":"Everitt","sequence":"additional","affiliation":[{"name":"Department of Pathology, Duke University School of Medicine, Duke University , Durham, North Carolina 27710, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon","family":"Zhang","sequence":"additional","affiliation":[{"name":"Nicholas School of the Environment, Duke University , Durham, North Carolina 27710, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bevin","family":"Blake","sequence":"additional","affiliation":[{"name":"Curriculum in Toxicology and Environmental Medicine, University of North Carolina at Chapel Hill , Chapel Hill, North Carolina 27599, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didrik","family":"Olofsson","sequence":"additional","affiliation":[{"name":"Omiqa Bioinformatics GmbH , Berlin 14195, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Duke University School of Medicine , Durham, North Carolina 27710, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather M","family":"Stapleton","sequence":"additional","affiliation":[{"name":"Integrated Toxicology and Environmental Health Program, Nicholas School of the Environment, Duke University , Durham, North Carolina 27710, USA"},{"name":"Nicholas School of the Environment, Duke University , Durham, North Carolina 27710, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8298-7272","authenticated-orcid":false,"given":"Susan K","family":"Murphy","sequence":"additional","affiliation":[{"name":"Integrated Toxicology and Environmental Health Program, Nicholas School of the Environment, Duke University , Durham, North Carolina 27710, USA"},{"name":"Department of Obstetrics and Gynecology, Duke University School of Medicine , Durham, North Carolina 27710, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Feng","sequence":"additional","affiliation":[{"name":"Integrated Toxicology and Environmental Health Program, Nicholas School of the Environment, Duke University , Durham, North Carolina 27710, USA"},{"name":"Department of Obstetrics and Gynecology, Duke University School of Medicine , Durham, North Carolina 27710, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,12,1]]},"reference":[{"key":"2023021707593599300_","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1038\/s41371-019-0264-1","article-title":"Ratio of diastolic to systolic blood pressure represents renal resistive index","volume":"34","author":"Akaishi","year":"2020","journal-title":"J. Hum. Hypertens"},{"key":"2023021707593599300_","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1111\/jch.13410","article-title":"Renal resistive index in hypertensive patients","volume":"20","author":"Andrikou","year":"2018","journal-title":"J. Clin. Hypertens. (Greenwich)"},{"key":"2023021707593599300_","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.metabol.2017.11.011","article-title":"Hypertensive complications of pregnancy: A clinical overview","volume":"86","author":"Antza","year":"2018","journal-title":"Metabolism"},{"key":"2023021707593599300_","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1016\/j.biocel.2011.05.016","article-title":"Type 2 deiodinase at the crossroads of thyroid hormone action","volume":"43","author":"Arrojo","year":"2011","journal-title":"Int. J. Biochem. Cell Biol"},{"key":"2023021707593599300_","doi-asserted-by":"crossref","first-page":"3956","DOI":"10.1016\/j.bbagen.2012.08.019","article-title":"Role of the type 2 iodothyronine deiodinase (D2) in the control of thyroid hormone signaling","volume":"1830","author":"Arrojo","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"2023021707593599300_","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0895-7061(00)01232-2","article-title":"Pulse pressure and aortic pulse wave are markers of cardiovascular risk in hypertensive populations","volume":"14","author":"Asmar","year":"2001","journal-title":"Am. J. Hypertens"},{"key":"2023021707593599300_","author":"ATSDR","year":"2019"},{"key":"2023021707593599300_","author":"ATSDR","year":"2021"},{"key":"2023021707593599300_","doi-asserted-by":"crossref","first-page":"53","DOI":"10.3109\/10408444.2014.952400","article-title":"Perfluoroalkyl and polyfluoroalkyl substances and human fetal growth: A systematic review","volume":"45","author":"Bach","year":"2015","journal-title":"Crit. Rev. Toxicol"},{"key":"2023021707593599300_","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/sj.jhh.1000933","article-title":"Relationships between cardiovascular remodelling and the pulse pressure in never treated hypertension","volume":"14","author":"Baguet","year":"2000","journal-title":"J. Hum. Hypertens"},{"key":"2023021707593599300_","doi-asserted-by":"crossref","first-page":"7650","DOI":"10.1007\/s11356-014-2594-4","article-title":"Perfluoroalkyl acids in blood serum samples from children in Taiwan","volume":"21","author":"Bao","year":"2014","journal-title":"Environ. Sci. Pollut. Res. Int"},{"key":"2023021707593599300_","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1210\/er.2018-00275","article-title":"Paradigms of dynamic control of thyroid hormone signaling","volume":"40","author":"Bianco","year":"2019","journal-title":"Endocr. Rev"},{"key":"2023021707593599300_","doi-asserted-by":"crossref","first-page":"152565","DOI":"10.1016\/j.tox.2020.152565","article-title":"Early life exposure to per- and polyfluoroalkyl substances (PFAS) and latent health outcomes: A review including the placenta as a target tissue and possible driver of peri- and postnatal effects","volume":"443","author":"Blake","year":"2020","journal-title":"Toxicology"},{"key":"2023021707593599300_","doi-asserted-by":"crossref","first-page":"27006","DOI":"10.1289\/EHP6233","article-title":"Evaluation of maternal, embryo, and placental effects in CD-1 mice following gestational exposure to perfluorooctanoic acid (PFOA) or hexafluoropropylene oxide dimer acid (HFPO-DA or GenX)","volume":"128","author":"Blake","year":"2020","journal-title":"Environ. Health Perspect"},{"key":"2023021707593599300_","doi-asserted-by":"crossref","first-page":"107004","DOI":"10.1289\/EHP9091","article-title":"Maternal levels of perfluoroalkyl substances (PFAS) during early pregnancy in relation to preeclampsia subtypes and biomarkers of preeclampsia risk","volume":"129","author":"Bommarito","year":"2021","journal-title":"Environ. Health Perspect"},{"key":"2023021707593599300_","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.ajog.2010.08.009","article-title":"The \u201cGreat Obstetrical Syndromes\u201d are associated with disorders of deep placentation","volume":"204","author":"Brosens","year":"2011","journal-title":"Am. J. Obstet. Gynecol"},{"key":"2023021707593599300_","doi-asserted-by":"crossref","first-page":"140017","DOI":"10.1016\/j.scitotenv.2020.140017","article-title":"PFAS concentrations in soils: Background levels versus contaminated sites","volume":"740","author":"Brusseau","year":"2020","journal-title":"Sci. Total Environ"},{"key":"2023021707593599300_","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1677\/joe.1.06582","article-title":"Monocarboxylate transporter 8 expression in the human placenta: The effects of severe intrauterine growth restriction","volume":"189","author":"Chan","year":"2006","journal-title":"J. Endocrinol"},{"key":"2023021707593599300_","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/ncpendmet1026","article-title":"The role of the placenta in thyroid hormone delivery to the fetus","volume":"5","author":"Chan","year":"2009","journal-title":"Nat. Clin. Pract. Endocrinol. Metab"},{"key":"2023021707593599300_","doi-asserted-by":"crossref","first-page":"i884","DOI":"10.1093\/bioinformatics\/bty560","article-title":"fastp: An ultra-fast all-in-one FASTQ preprocessor","volume":"34","author":"Chen","year":"2018","journal-title":"Bioinformatics"},{"key":"2023021707593599300_","doi-asserted-by":"crossref","first-page":"156499","DOI":"10.1016\/j.scitotenv.2022.156499","article-title":"Evaluating maternal exposure to an environmental per and polyfluoroalkyl substances (PFAS) mixture during pregnancy: Adverse maternal and fetoplacental effects in a New Zealand White (NZW) rabbit model","volume":"838","author":"Crute","year":"2022","journal-title":"Sci. Total Environ"},{"key":"2023021707593599300_","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1161\/01.HYP.0000158268.95012.08","article-title":"Is high pulse pressure a marker of preclinical cardiovascular disease?","volume":"45","author":"de Simone","year":"2005","journal-title":"Hypertension"},{"key":"2023021707593599300_","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1530\/REP-18-0633","article-title":"Dysregulation of the placental renin-angiotensin system in human fetal growth restriction","volume":"158","author":"Delforce","year":"2019","journal-title":"Reproduction"},{"key":"2023021707593599300_","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: Ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"2023021707593599300_","doi-asserted-by":"crossref","first-page":"108648","DOI":"10.1016\/j.envres.2019.108648","article-title":"Human exposure to per- and polyfluoroalkyl substances (PFAS) through drinking water: A review of the recent scientific literature","volume":"177","author":"Domingo","year":"2019","journal-title":"Environ. Res"},{"key":"2023021707593599300_","doi-asserted-by":"crossref","first-page":"3857","DOI":"10.1080\/14767058.2019.1586875","article-title":"The placenta in fetal thyroid hormone delivery: From normal physiology to adaptive mechanisms in complicated pregnancies","volume":"33","author":"Eerdekens","year":"2020","journal-title":"J. Matern. Fetal Neonatal Med"},{"key":"2023021707593599300_","author":"EPA","year":"2022"},{"key":"2023021707593599300_","author":"(EWG)","year":"2021"},{"key":"2023021707593599300_","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1093\/toxsci\/kfw219","article-title":"Exposure of pregnant mice to perfluorobutanesulfonate causes hypothyroxinemia and developmental abnormalities in female offspring","volume":"155","author":"Feng","year":"2017","journal-title":"Toxicol. Sci"},{"key":"2023021707593599300_","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/S0890-6238(00)00101-5","article-title":"The rabbit as a model for reproductive and developmental toxicity studies","volume":"14","author":"Foote","year":"2000","journal-title":"Reprod. Toxicol"},{"key":"2023021707593599300_","doi-asserted-by":"crossref","first-page":"11447","DOI":"10.1021\/acs.est.9b01746","article-title":"Perfluoroalkyl acids (PFAAs) in children's serum and contribution from PFAA-contaminated drinking water","volume":"53","author":"Gyllenhammar","year":"2019","journal-title":"Environ. Sci. Technol"},{"key":"2023021707593599300_","doi-asserted-by":"crossref","first-page":"14558","DOI":"10.1021\/acs.est.0c04869","article-title":"Per- and polyfluoroalkyl substances in dust collected from residential homes and fire stations in North America","volume":"54","author":"Hall","year":"2020","journal-title":"Environ. Sci. Technol"},{"key":"2023021707593599300_","doi-asserted-by":"crossref","first-page":"28","DOI":"10.3389\/fphys.2016.00028","article-title":"Placental adaptation: What can we learn from birthweight: Placental weight ratio?","volume":"7","author":"Hayward","year":"2016","journal-title":"Front. Physiol"},{"key":"2023021707593599300_","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1093\/ije\/dyl080","article-title":"The association between intrauterine growth restriction in the full-term infant and high blood pressure at age 7 years: Results from the Collaborative Perinatal Project","volume":"35","author":"Hemachandra","year":"2006","journal-title":"Int. J. Epidemiol"},{"key":"2023021707593599300_","volume-title":"Reproductive and Developmental Toxicology","author":"Hoberman","year":"2017","edition":"2nd"},{"key":"2023021707593599300_","doi-asserted-by":"crossref","first-page":"110156","DOI":"10.1016\/j.envres.2020.110156","article-title":"Association between prenatal exposure to perfluoroalkyl substances and respiratory tract infections in preschool children","volume":"191","author":"Huang","year":"2020","journal-title":"Environ. Res"},{"key":"2023021707593599300_","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.toxrep.2019.06.016","article-title":"Toxicokinetics of perfluorobutane sulfonate (PFBS), perfluorohexane-1-sulphonic acid (PFHxS), and perfluorooctane sulfonic acid (PFOS) in male and female Hsd: Sprague Dawley SD rats after intravenous and gavage administration","volume":"6","author":"Huang","year":"2019","journal-title":"Toxicol. Rep."},{"key":"2023021707593599300_","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s12940-018-0445-3","article-title":"Prenatal exposure to perfluoroalkyl and polyfluoroalkyl substances and the risk of hypertensive disorders of pregnancy","volume":"18","author":"Huang","year":"2019","journal-title":"Environ. Health"},{"key":"2023021707593599300_","doi-asserted-by":"crossref","first-page":"105656","DOI":"10.1016\/j.envint.2020.105656","article-title":"Perfluoroalkyl substances in early pregnancy and risk of hypertensive disorders of pregnancy: A prospective cohort study","volume":"138","author":"Huo","year":"2020","journal-title":"Environ. Int"},{"key":"2023021707593599300_","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1097\/AOG.0b013e318253d3df","article-title":"Placental weight for gestational age and adverse perinatal outcomes","volume":"119","author":"Hutcheon","year":"2012","journal-title":"Obstet. Gynecol"},{"key":"2023021707593599300_","author":"ITRC","year":"2020"},{"key":"2023021707593599300_","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v082.i13","article-title":"lmerTest package: Tests in linear mixed effects models","volume":"82","author":"Kuznetsova","year":"2017","journal-title":"J. Stat. Soft"},{"key":"2023021707593599300_","doi-asserted-by":"crossref","first-page":"7317639","DOI":"10.1155\/2019\/7317639","article-title":"Scavenger receptor class B member 1 independent uptake of transthyretin by cultured hepatocytes is regulated by high density lipoprotein","volume":"2019","author":"Landers","year":"2019","journal-title":"J. Lipids"},{"key":"2023021707593599300_","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.mce.2018.02.014","article-title":"Transthyretin uptake in placental cells is regulated by the high-density lipoprotein receptor, scavenger receptor class B member 1","volume":"474","author":"Landers","year":"2018","journal-title":"Mol. Cell. Endocrinol"},{"key":"2023021707593599300_","doi-asserted-by":"publisher","DOI":"10.3791\/62317","article-title":"Intranasal immunization and milk collection in studies of maternal immunization in New Zealand White Rabbits (Oryctolagus cuniculus)","author":"Landon","year":"2021","journal-title":"J. Vis. Exp"},{"key":"2023021707593599300_","doi-asserted-by":"crossref","first-page":"150393","DOI":"10.1016\/j.scitotenv.2021.150393","article-title":"Assessment of per- and polyfluoroalkyl substances in Biscayne Bay surface waters and tap waters from South Florida","volume":"806","author":"Li","year":"2021","journal-title":"Sci. Total Environ"},{"key":"2023021707593599300_","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.placenta.2016.01.010","article-title":"In utero perfluorooctane sulfonate exposure causes low body weights of fetal rats: A mechanism study","volume":"39","author":"Li","year":"2016","journal-title":"Placenta"},{"key":"2023021707593599300_","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.envint.2018.11.036","article-title":"Perfluoroalkyl acids in drinking water of China in 2017: Distribution characteristics, influencing factors and potential risks","volume":"123","author":"Li","year":"2019","journal-title":"Environ. Int"},{"key":"2023021707593599300_","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.tox.2008.10.002","article-title":"Toxicological evaluation of potassium perfluorobutanesulfonate in a 90-day oral gavage study with Sprague-Dawley rats","volume":"255","author":"Lieder","year":"2009","journal-title":"Toxicology"},{"key":"2023021707593599300_","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.tox.2009.01.027","article-title":"A two-generation oral gavage reproduction study with potassium perfluorobutanesulfonate (K+PFBS) in Sprague Dawley rats","volume":"259","author":"Lieder","year":"2009","journal-title":"Toxicology"},{"key":"2023021707593599300_","doi-asserted-by":"crossref","first-page":"4260","DOI":"10.1021\/acs.analchem.5b00039","article-title":"Discovery of C5-C17 poly- and perfluoroalkyl substances in water by in-line SPE-HPLC-Orbitrap with in-source fragmentation flagging","volume":"87","author":"Liu","year":"2015","journal-title":"Anal. Chem."},{"key":"2023021707593599300_","doi-asserted-by":"crossref","first-page":"132468","DOI":"10.1016\/j.chemosphere.2021.132468","article-title":"Exposure to perfluoroalkyl substances in early pregnancy and the risk of hypertensive disorders of pregnancy: A nested case-control study in Guangxi, China","volume":"288","author":"Liu","year":"2022","journal-title":"Chemosphere"},{"key":"2023021707593599300_","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1080\/14767058.2019.1636371","article-title":"Placental weight and size in relation to fetal growth restriction: A case-control study","volume":"34","author":"Liu","year":"2021","journal-title":"J. Matern. Fetal Neonatal Med"},{"key":"2023021707593599300_","doi-asserted-by":"crossref","first-page":"105636","DOI":"10.1016\/j.envint.2020.105636","article-title":"Associations of per-\/polyfluoroalkyl substances with glucocorticoids and progestogens in newborns","volume":"140","author":"Liu","year":"2020","journal-title":"Environ. Int"},{"key":"2023021707593599300_","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"2023021707593599300_","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol"},{"key":"2023021707593599300_","first-page":"2599","article-title":"Differential roles of Scavenger receptor class B type I: A protective molecule and a facilitator of atherosclerosis (Review)","volume":"22","author":"Ma","year":"2020","journal-title":"Mol. Med. Rep"},{"key":"2023021707593599300_","doi-asserted-by":"crossref","first-page":"14182","DOI":"10.1096\/fj.202000716RR","article-title":"Perfluorobutane sulfonate exposure disrupted human placental cytotrophoblast cell proliferation and invasion involving in dysregulating preeclampsia related genes","volume":"34","author":"Marinello","year":"2020","journal-title":"FASEB J"},{"key":"2023021707593599300_","doi-asserted-by":"crossref","first-page":"e012611","DOI":"10.1161\/JAHA.119.012611","article-title":"Evidence of augmented intrarenal angiotensinogen associated with glomerular swelling in gestational hypertension and preeclampsia: Clinical implications","volume":"8","author":"Mistry","year":"2019","journal-title":"J. Am. Heart Assoc"},{"key":"2023021707593599300_","author":"(NTP)","year":"2018"},{"key":"2023021707593599300_","author":"NTP","year":"2019"},{"key":"2023021707593599300_","author":"NTP","year":"2019"},{"key":"2023021707593599300_","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1289\/ehp.10009","article-title":"Half-life of serum elimination of perfluorooctanesulfonate, perfluorohexanesulfonate, and perfluorooctanoate in retired fluorochemical production workers","volume":"115","author":"Olsen","year":"2007","journal-title":"Environ. Health Perspect"},{"key":"2023021707593599300_","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.tox.2008.11.008","article-title":"A comparison of the pharmacokinetics of perfluorobutanesulfonate (PFBS) in rats, monkeys, and humans","volume":"256","author":"Olsen","year":"2009","journal-title":"Toxicology"},{"key":"2023021707593599300_","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.chemosphere.2006.12.031","article-title":"Preliminary evidence of a decline in perfluorooctanesulfonate (PFOS) and perfluorooctanoate (PFOA) concentrations in American Red Cross blood donors","volume":"68","author":"Olsen","year":"2007","journal-title":"Chemosphere"},{"key":"2023021707593599300_","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.reprotox.2020.10.013","article-title":"Exposure to perfluorobutane sulfonate and perfluorooctanesulfonic acid disrupts the production of angiogenesis factors and stress responses in human placental syncytiotrophoblast","volume":"98","author":"Pham","year":"2020","journal-title":"Reprod. Toxicol"},{"key":"2023021707593599300_","doi-asserted-by":"crossref","first-page":"126361","DOI":"10.1016\/j.jhazmat.2021.126361","article-title":"Per and poly-fluoroalkyl substances (PFAS) as a contaminant of emerging concern in surface water: A transboundary review of their occurrences and toxicity effects","volume":"419","author":"Podder","year":"2021","journal-title":"J. Hazard. Mater"},{"key":"2023021707593599300_","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/j.placenta.2011.09.020","article-title":"The expression and localization of the human placental prorenin\/renin-angiotensin system throughout pregnancy: Roles in trophoblast invasion and angiogenesis?","volume":"32","author":"Pringle","year":"2011","journal-title":"Placenta"},{"key":"2023021707593599300_","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1161\/hy0202.103782","article-title":"Renal resistance index and progression of renal disease","volume":"39","author":"Radermacher","year":"2002","journal-title":"Hypertension"},{"key":"2023021707593599300_","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1093\/aje\/kwp182","article-title":"Placental weight relative to birth weight and long-term cardiovascular mortality: Findings from a cohort of 31,307 men and women","volume":"170","author":"Risnes","year":"2009","journal-title":"Am. J. Epidemiol"},{"key":"2023021707593599300_","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.preghy.2012.01.001","article-title":"The placenta in preeclampsia","volume":"2","author":"Roberts","year":"2012","journal-title":"Pregnancy Hypertens."},{"key":"2023021707593599300_","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1002\/bdra.20345","article-title":"Placental growth patterns affect birth weight for given placental weight","volume":"79","author":"Salafia","year":"2007","journal-title":"Birth Defects Res. A Clin. Mol. Teratol"},{"key":"2023021707593599300_","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1093\/aje\/kwp212","article-title":"Serum levels of perfluorooctanoic acid and perfluorooctane sulfonate and pregnancy outcome","volume":"170","author":"Stein","year":"2009","journal-title":"Am. J. Epidemiol"},{"key":"2023021707593599300_","first-page":"275","article-title":"False discovery rates: A new deal","volume":"18","author":"Stephens","year":"2017","journal-title":"Biostatistics"},{"key":"2023021707593599300_","doi-asserted-by":"crossref","first-page":"127659","DOI":"10.1016\/j.chemosphere.2020.127659","article-title":"Disposal of products and materials containing per- and polyfluoroalkyl substances (PFAS): A cyclical problem","volume":"260","author":"Stoiber","year":"2020","journal-title":"Chemosphere"},{"key":"2023021707593599300_","author":"Sutherland-Ashley","year":"2021"},{"key":"2023021707593599300_","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1007\/s40572-020-00279-0","article-title":"Perfluoroalkyl substances (PFAS) and their effects on the placenta, pregnancy, and child development: A potential mechanistic role for placental peroxisome proliferator-activated receptors (PPARs)","volume":"7","author":"Szilagyi","year":"2020","journal-title":"Curr. Environ. Health Rep"},{"issue":"Suppl","key":"2023021707593599300_","doi-asserted-by":"crossref","first-page":"S54","DOI":"10.1016\/j.placenta.2010.01.002","article-title":"Review: The placenta is a programming agent for cardiovascular disease","volume":"31","author":"Thornburg","year":"2010","journal-title":"Placenta"},{"key":"2023021707593599300_","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1046\/j.1523-1755.2002.00173.x","article-title":"Pulse pressure and risk of total mortality and cardiovascular events in patients on chronic hemodialysis","volume":"61","author":"Tozawa","year":"2002","journal-title":"Kidney Int"},{"key":"2023021707593599300_","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1016\/j.chemosphere.2019.06.228","article-title":"Assessment of perfluoroalkyl substances levels in tap and bottled water samples from Turkey","volume":"235","author":"\u00dcnl\u00fc Endirlik","year":"2019","journal-title":"Chemosphere"},{"key":"2023021707593599300_","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/1471-2350-11-90","article-title":"Maternal angiotensinogen (AGT) haplotypes, fetal renin (REN) haplotypes and risk of preeclampsia; estimation of gene-gene interaction from family-triad data","volume":"11","author":"Vefring","year":"2010","journal-title":"BMC Med. Genet."},{"key":"2023021707593599300_","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.mce.2011.02.003","article-title":"The thyroid hormone transporters MCT8 and MCT10 transport the affinity-label N-bromoacetyl-[(125)I]T3 but are not modified by it","volume":"337","author":"Visser","year":"2011","journal-title":"Mol. Cell. Endocrinol"},{"key":"2023021707593599300_","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.envint.2017.03.003","article-title":"Perfluoroalkyl substances and endometriosis-related infertility in Chinese women","volume":"102","author":"Wang","year":"2017","journal-title":"Environ. Int"},{"key":"2023021707593599300_","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1007\/s00216-010-3705-9","article-title":"Analysis of thyroid hormones in serum by liquid chromatography-tandem mass spectrometry","volume":"397","author":"Wang","year":"2010","journal-title":"Anal. Bioanal. Chem"},{"key":"2023021707593599300_","doi-asserted-by":"crossref","first-page":"9179","DOI":"10.1038\/s41598-019-45483-7","article-title":"Early pregnancy serum levels of perfluoroalkyl substances and risk of preeclampsia in Swedish women","volume":"9","author":"Wikstrom","year":"2019","journal-title":"Sci. Rep."},{"key":"2023021707593599300_","doi-asserted-by":"crossref","first-page":"77004","DOI":"10.1289\/EHP6785","article-title":"Serum half-lives for short- and long-chain perfluoroalkyl acids after ceasing exposure from drinking water contaminated by firefighting foam","volume":"128","author":"Xu","year":"2020","journal-title":"Environ. Health Perspect"},{"key":"2023021707593599300_","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.envint.2019.03.047","article-title":"Cord blood per- and polyfluoroalkyl substances, placental steroidogenic enzyme, and cord blood reproductive hormone","volume":"129","author":"Yao","year":"2019","journal-title":"Environ. Int"},{"key":"2023021707593599300_","author":"York","year":"2002"},{"key":"2023021707593599300_","author":"York","year":"2003"},{"key":"2023021707593599300_","doi-asserted-by":"crossref","first-page":"111695","DOI":"10.1016\/j.fct.2020.111695","article-title":"Perfluorooctanesulfonic acid (PFOS) and perfluorobutanesulfonic acid (PFBS) impaired reproduction and altered offspring physiological functions in Caenorhabditis elegans","volume":"145","author":"Yue","year":"2020","journal-title":"Food Chem. Toxicol"},{"key":"2023021707593599300_","first-page":"2048","article-title":"Determination of perfluoroalkylated substances (PFASs) in drinking water from the Netherlands and Greece","volume":"32","author":"Zafeiraki","year":"2015","journal-title":"Food Addit. Contam. Part A Chem. Anal. Control. Expo. Risk Assess"},{"key":"2023021707593599300_","doi-asserted-by":"crossref","first-page":"152446","DOI":"10.1016\/j.scitotenv.2021.152446","article-title":"Prenatal and postnatal exposure to emerging and legacy per-\/polyfluoroalkyl substances: Levels and transfer in maternal serum, cord serum, and breast milk","volume":"812","author":"Zheng","year":"2022","journal-title":"Sci. Total Environ"}],"container-title":["Toxicological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/toxsci\/advance-article-pdf\/doi\/10.1093\/toxsci\/kfac126\/47804889\/kfac126.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/toxsci\/article-pdf\/191\/2\/239\/49199033\/kfac126.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/toxsci\/article-pdf\/191\/2\/239\/49199033\/kfac126.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,15]],"date-time":"2023-03-15T00:01:37Z","timestamp":1678838497000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/toxsci\/article\/191\/2\/239\/6858513"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,1]]},"references-count":92,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022,12,1]]},"published-print":{"date-parts":[[2023,2,17]]}},"URL":"https:\/\/doi.org\/10.1093\/toxsci\/kfac126","relation":{},"ISSN":["1096-6080","1096-0929"],"issn-type":[{"value":"1096-6080","type":"print"},{"value":"1096-0929","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,2,1]]},"published":{"date-parts":[[2022,12,1]]}}}