{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T02:49:37Z","timestamp":1789181377413,"version":"build-2803163510"},"reference-count":68,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2023,3,6]],"date-time":"2023-03-06T00:00:00Z","timestamp":1678060800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"UC Davis and Iowa State University for Wilson Rumbeiha"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,4,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Acute exposure to high concentrations of hydrogen sulfide (H2S) leads to sudden death and, if survived, lingering neurological disorders. Clinical signs include seizures, loss of consciousness, and dyspnea. The proximate mechanisms underlying H2S-induced acute toxicity and death have not been clearly elucidated. We investigated electrocerebral, cardiac, and respiratory activity during H2S exposure using electroencephalogram (EEG), electrocardiogram, and plethysmography. H2S suppressed electrocerebral activity and disrupted breathing. Cardiac activity was comparatively less affected. To test whether Ca2+ dysregulation contributes to H2S-induced EEG suppression, we developed an in vitro real-time rapid throughput assay measuring patterns of spontaneous synchronized Ca2+ oscillations in cultured primary cortical neuronal networks loaded with the indicator Fluo-4 using the fluorescent imaging plate reader (FLIPR-Tetra\u00ae). Sulfide &amp;gt;5\u2009ppm dysregulated synchronous calcium oscillation (SCO) patterns in a dose-dependent manner. Inhibitors of NMDA and AMPA receptors magnified H2S-induced SCO suppression. Inhibitors of L-type voltage-gated Ca2+ channels and transient receptor potential (TRP) channels prevented H2S-induced SCO suppression. Inhibitors of T-type voltage-gated Ca2+ channels, ryanodine receptors, and sodium channels had no measurable influence on H2S-induced SCO suppression. Exposures to &amp;gt;5\u2009ppm sulfide also suppressed neuronal electrical activity in primary cortical neurons measured by multielectrode array (MEA), an effect alleviated by pretreatment with the nonselective TRP channel inhibitor, 2-aminoethoxydiphenylborate (2-APB). 2-APB also reduced primary cortical neuronal cell death from sulfide exposure. These results improve our understanding of the role of different Ca2+ channels in acute H2S-induced neurotoxicity and identify TRP channel modulators as novel structures with potential therapeutic benefits.<\/jats:p>","DOI":"10.1093\/toxsci\/kfad022","type":"journal-article","created":{"date-parts":[[2023,3,4]],"date-time":"2023-03-04T01:24:38Z","timestamp":1677893078000},"page":"247-264","source":"Crossref","is-referenced-by-count":16,"title":["Investigations into hydrogen sulfide-induced suppression of neuronal activity\n                    <i>in vivo<\/i>\n                    and calcium dysregulation\n                    <i>in vitro<\/i>"],"prefix":"10.1093","volume":"192","author":[{"given":"Dong-Suk","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis , Davis, California 95616, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8149-588X","authenticated-orcid":false,"given":"Isaac N","family":"Pessah","sequence":"additional","affiliation":[{"name":"Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis , Davis, California 95616, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina M","family":"Santana","sequence":"additional","affiliation":[{"name":"VDPAM, College of Veterinary Medicine, Iowa State University , Ames, Iowa 50011, USA"},{"name":"MRIGlobal , Kansas City, Missouri 64110, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8750-6810","authenticated-orcid":false,"given":"Benton S","family":"Purnell","sequence":"additional","affiliation":[{"name":"Department of Neurology, Iowa Neuroscience Institute, Carver College of Medicine, University of Iowa , Iowa City, Iowa 52246, USA"},{"name":"Department of Nerosurgery, Robert Wood Johnson Medical School, Rutgers University , Piscataway, New Jersey 08854, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology, Iowa Neuroscience Institute, Carver College of Medicine, University of Iowa , Iowa City, Iowa 52246, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon F","family":"Buchanan","sequence":"additional","affiliation":[{"name":"Department of Neurology, Iowa Neuroscience Institute, Carver College of Medicine, University of Iowa , Iowa City, Iowa 52246, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilson K","family":"Rumbeiha","sequence":"additional","affiliation":[{"name":"Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis , Davis, California 95616, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,3,6]]},"reference":[{"key":"2023041718434892700_","doi-asserted-by":"crossref","first-page":"290","DOI":"10.3389\/fncel.2014.00290","article-title":"A synaptic mechanism for network synchrony","volume":"8","author":"Alford","year":"2014","journal-title":"Front. 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Lett"},{"key":"2023041718434892700_","doi-asserted-by":"crossref","first-page":"83","DOI":"10.2486\/indhealth.42.83","article-title":"Neurologic sequela of hydrogen sulfide poisoning","volume":"42","author":"Nam","year":"2004","journal-title":"Ind. Health"},{"key":"2023041718434892700_","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/s13181-019-00710-5","article-title":"Hydrogen sulfide toxicity: Mechanism of action, clinical presentation, and countermeasure development","volume":"15","author":"Ng","year":"2019","journal-title":"J. Med. Toxicol"},{"key":"2023041718434892700_","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1111\/j.1460-9568.1996.tb01180.x","article-title":"Mechanisms for synchronous calcium oscillations in cultured rat cerebellar neurons","volume":"8","author":"Nunez","year":"1996","journal-title":"Eur. J. Neurosci"},{"key":"2023041718434892700_","first-page":"217","article-title":"Hydrogen sulphide poisoning in swine","volume":"25","author":"O'Donoghue","year":"1961","journal-title":"Can. J. Compar. Med. Vet. Sci"},{"key":"2023041718434892700_","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1161\/CIRCRESAHA.114.300505","article-title":"Emergence of hydrogen sulfide as an endogenous gaseous signaling molecule in cardiovascular disease","volume":"114","author":"Polhemus","year":"2014","journal-title":"Circ. Res"},{"key":"2023041718434892700_","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1111\/bph.14514","article-title":"Effects of sulfide and polysulfides transmitted by direct or signal transduction-mediated activation of trpa1 channels","volume":"176","author":"Pozsgai","year":"2019","journal-title":"Br. J. Pharmacol"},{"key":"2023041718434892700_","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1152\/japplphysiol.00211.2020","article-title":"Free-running circadian breathing rhythms are eliminated by suprachiasmatic nucleus lesion","volume":"129","author":"Purnell","year":"2020","journal-title":"J. Appl. Physiol"},{"key":"2023041718434892700_","doi-asserted-by":"crossref","first-page":"2592","DOI":"10.1152\/jn.00039.2017","article-title":"Time-of-day influences on respiratory sequelae following maximal electroshock-induced seizures in mice","volume":"118","author":"Purnell","year":"2017","journal-title":"J. Neurophysiol"},{"key":"2023041718434892700_","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12868-018-0483-3","article-title":"Possible involvement of peripheral trp channels in the hydrogen sulfide-induced hyperalgesia in diabetic rats","volume":"20","author":"Roa-Coria","year":"2019","journal-title":"BMC Neurosci"},{"key":"2023041718434892700_","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1152\/jn.1993.70.4.1606","article-title":"Periodic synchronized bursting and intracellular calcium transients elicited by low magnesium in cultured cortical neurons","volume":"70","author":"Robinson","year":"1993","journal-title":"J. Neurophysiol"},{"key":"2023041718434892700_","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/nyas.13148","article-title":"Acute hydrogen sulfide-induced neuropathology and neurological sequelae: Challenges for translational neuroprotective research","volume":"1378","author":"Rumbeiha","year":"2016","journal-title":"Ann. N. Y. Acad. Sci"},{"key":"2023041718434892700_","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/978-981-10-7757-9_6","article-title":"Transient receptor potential (TRP) channels","volume":"87","author":"Samanta","year":"2018","journal-title":"Subcell Biochem"},{"key":"2023041718434892700_","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1080\/15376516.2022.2121192","article-title":"A comprehensive review of treatments for hydrogen sulfide poisoning: Past, present, and future","volume":"33","author":"Santana Maldonado","year":"2022","journal-title":"Toxicol. Mech. Methods"},{"key":"2023041718434892700_","doi-asserted-by":"crossref","first-page":"4708","DOI":"10.1523\/JNEUROSCI.4917-08.2009","article-title":"Expression of human amyloid precursor protein in rat cortical neurons inhibits calcium oscillations","volume":"29","author":"Santos","year":"2009","journal-title":"J. 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Med"},{"key":"2023041718434892700_","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1152\/jn.1995.73.4.1706","article-title":"Recurrent spontaneous seizure activity in hippocampal neuronal networks in culture","volume":"73","author":"Sombati","year":"1995","journal-title":"J. Neurophysiol"},{"key":"2023041718434892700_","doi-asserted-by":"crossref","first-page":"525","DOI":"10.3109\/15563650.2015.1043440","article-title":"H2s induced coma and cardiogenic shock in the rat: Effects of phenothiazinium chromophores","volume":"53","author":"Sonobe","year":"2015","journal-title":"Clin. Toxicol"},{"key":"2023041718434892700_","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1038\/sj.bjp.0707335","article-title":"IP(3) receptor antagonist, 2-APB, attenuates cisplatin induced Ca2+-influx in HeLa-S3 cells and prevents activation of calpain and induction of apoptosis","volume":"151","author":"Splettstoesser","year":"2007","journal-title":"Br. J. 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