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We hypothesized that adolescent exposure to THC affects ovarian function in adulthood. Peripubertal female C57BL\/6N mice were given THC (5\u2009mg\/kg) or its vehicle, once daily by intraperitoneal injection. Some mice received THC from postnatal day (PND) 30\u201333 and their ovaries were harvested PND34; other mice received THC from PND30\u201343, and their ovaries were harvested PND70. Adolescent treatment with THC depleted ovarian primordial follicle numbers by 50% at PND70, 4\u2009weeks after the last dose. The treatment produced primordial follicle activation, which persisted until PND70. THC administration also caused DNA damage in primary follicles and increased PUMA protein expression in oocytes of primordial and primary follicles. Both CB1R and CB2R were expressed in oocytes and theca cells of ovarian follicles. Enzymes involved in the formation (N-acylphosphatidylethanolamine phospholipase D) or deactivation (fatty acid amide hydrolase) of the endocannabinoid anandamide were expressed in granulosa cells of ovarian follicles and interstitial cells. Levels of mRNA for CBR1 were significantly increased in ovaries after adolescent THC exposure, and upregulation persisted for at least 4\u2009weeks. Our results support that adolescent exposure to THC may cause aberrant activation of the ovarian endocannabinoid system in female mice, resulting in substantial loss of ovarian reserve in adulthood. Relevance of these findings to women who frequently used cannabis during adolescence warrants investigation.<\/jats:p>","DOI":"10.1093\/toxsci\/kfad027","type":"journal-article","created":{"date-parts":[[2023,3,13]],"date-time":"2023-03-13T16:29:22Z","timestamp":1678724962000},"page":"31-47","source":"Crossref","is-referenced-by-count":6,"title":["Adolescent exposure to low-dose \u03949-tetrahydrocannabinol depletes the ovarian reserve in female mice"],"prefix":"10.1093","volume":"193","author":[{"given":"Jinhwan","family":"Lim","sequence":"first","affiliation":[{"name":"Department of Environmental and Occupational Health, University of California Irvine , Irvine, California 92697, USA"},{"name":"Dept. of Medicine, University of California Irvine , Irvine, California 92697, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hye-Lim","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Neurobiology, University of California Irvine , 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