{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T23:20:02Z","timestamp":1784676002731,"version":"3.55.0"},"reference-count":69,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,6,16]],"date-time":"2023-06-16T00:00:00Z","timestamp":1686873600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81773385"],"award-info":[{"award-number":["81773385"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2019A1515011298"],"award-info":[{"award-number":["2019A1515011298"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2022A1515010727"],"award-info":[{"award-number":["2022A1515010727"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010226","name":"Guangdong Provincial Department of Education","doi-asserted-by":"crossref","award":["2022ZDZX2047"],"award-info":[{"award-number":["2022ZDZX2047"]}],"id":[{"id":"10.13039\/501100010226","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,8,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Increasing evidence shows that circular RNA (circRNA) plays an important role in the progression of lung cancer. In this study, we found that has_circ_0000043 was highly expressed in 16HBE-T human bronchial epithelial cells that were malignantly transformed by benzo[a]pyrene-trans-7,8-diol-9,10-epoxide via circRNA microarray. We verified that hsa_circ_0000043 was also significantly overexpressed in lung cancer cell lines and tissues. Moreover, hsa_circ_0000043 overexpression was positively correlated with poor clinicopathological parameters, such as tumor-node metastasis stage, distant metastasis, lymph-node metastasis, and overall survival. In vitro assays revealed that hsa_circ_0000043 inhibition suppressed 16HBE-T cell proliferation, migration, and invasion. Furthermore, hsa_circ_0000043 inhibition suppressed tumor growth in a mouse xenograft model. We discovered that hsa_circ_0000043 binds with miR-4492, acting as a miR-4492 sponge. Decreased miR-4492 expression was also associated with poor clinicopathological parameters. Thus, hsa_circ_0000043 was shown to contribute to the proliferation, malignant transformation ability, migration, and invasion of 16HBE-T cells via miR-4492 sponging and BDNF and STAT3 involvement.<\/jats:p>","DOI":"10.1093\/toxsci\/kfad060","type":"journal-article","created":{"date-parts":[[2023,6,16]],"date-time":"2023-06-16T15:24:02Z","timestamp":1686929042000},"page":"87-102","source":"Crossref","is-referenced-by-count":6,"title":["CircRNA <i>hsa_circ_0000043<\/i> acts as a <i>miR-4492<\/i> sponge to promote lung cancer progression via <i>BDNF<\/i> and <i>STAT3<\/i> expression regulation in anti-benzo[a]pyrene-trans-7,8-dihydrodiol-9,10-epoxide-transformed 16HBE cells"],"prefix":"10.1093","volume":"195","author":[{"given":"Jiayu","family":"Liu","sequence":"first","affiliation":[{"name":"The Institute for Chemical Carcinogenesis, School of Public Health, Guangzhou Medical University , Xinzao, Guangzhou 511436, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaying","family":"Xie","sequence":"additional","affiliation":[{"name":"The Institute for Chemical Carcinogenesis, School of Public Health, Guangzhou Medical University , Xinzao, Guangzhou 511436, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enwu","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, General Hospital of Southern Theater Command, PLA , Guangzhou 510010, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binhe","family":"Xu","sequence":"additional","affiliation":[{"name":"Basic Medicine College, Zunyi Medical University , Zunyi 563000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxin","family":"Zhou","sequence":"additional","affiliation":[{"name":"The Institute for Chemical Carcinogenesis, School of Public Health, Guangzhou Medical University , Xinzao, Guangzhou 511436, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiazhen","family":"Zhou","sequence":"additional","affiliation":[{"name":"The Institute for Chemical Carcinogenesis, School of Public Health, Guangzhou Medical University , Xinzao, Guangzhou 511436, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaoyuan","family":"Yang","sequence":"additional","affiliation":[{"name":"The Institute for Chemical Carcinogenesis, School of Public Health, Guangzhou Medical University , Xinzao, Guangzhou 511436, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,6,16]]},"reference":[{"key":"2023082912302472500_kfad060-B1","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1186\/s12913-017-2374-1","article-title":"Cost-effectiveness of lung cancer screening and treatment methods: a systematic review of systematic reviews","volume":"17","author":"Azar","year":"2017","journal-title":"BMC Health Serv. Res"},{"key":"2023082912302472500_kfad060-B2","doi-asserted-by":"crossref","first-page":"427","DOI":"10.7150\/ijbs.12777","article-title":"MiRNA transcriptome profiling of spheroid-enriched cells with cancer stem cell properties in human breast MCF-7 cell line","volume":"12","author":"Boo","year":"2016","journal-title":"Int. J. Biol. Sci"},{"key":"2023082912302472500_kfad060-B3","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.1093\/nar\/gkv115","article-title":"High-throughput data integration of RNA-miRNA-circRNA reveals novel insights into mechanisms of benzo[a]pyrene-induced carcinogenicity","volume":"43","author":"Caiment","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"2023082912302472500_kfad060-B4","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.cell.2014.03.008","article-title":"The noncoding RNA revolution-trashing old rules to forge new ones","volume":"157","author":"Cech","year":"2014","journal-title":"Cell"},{"key":"2023082912302472500_kfad060-B5","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1080\/15384101.2018.1515553","article-title":"Circrna hsa_circ_100395 regulates mir-1228\/tcf21 pathway to inhibit lung cancer progression","volume":"17","author":"Chen","year":"2018","journal-title":"Cell Cycle"},{"key":"2023082912302472500_kfad060-B6","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.bbrc.2018.11.176","article-title":"CircPUM1 promotes the malignant behavior of lung adenocarcinoma by regulating miR-326","volume":"508","author":"Chen","year":"2019","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"2023082912302472500_kfad060-B7","doi-asserted-by":"crossref","DOI":"10.1186\/s12943-019-0943-0","article-title":"Circular RNA 100146 functions as an oncogene through direct binding to miR-361-3p and miR-615-5p in non-small cell lung cancer","volume":"18","author":"Chen","year":"2019","journal-title":"Mol. Cancer"},{"key":"2023082912302472500_kfad060-B8","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.canlet.2019.10.017","article-title":"CircRNA cRAPGEF5 inhibits the growth and metastasis of renal cell carcinoma via the miR-27a-3p\/TXNIP pathway","volume":"469","author":"Chen","year":"2020","journal-title":"Cancer Lett"},{"key":"2023082912302472500_kfad060-B9","doi-asserted-by":"crossref","first-page":"5510869","DOI":"10.1155\/2021\/5510869","article-title":"Circ_0044516 regulates miR-136\/MAT2A pathway to facilitate lung cancer development","volume":"2021","author":"Chen","year":"2021","journal-title":"J. Immunol. Res"},{"key":"2023082912302472500_kfad060-B10","doi-asserted-by":"crossref","first-page":"163","DOI":"10.3892\/or.2022.8378","article-title":"Overexpressed lncRNA FTX promotes the cell viability, proliferation, migration and invasion of renal cell carcinoma via FTX\/miR-4429\/UBE2C axis","volume":"48","author":"Chen","year":"2022","journal-title":"Oncol. Rep"},{"key":"2023082912302472500_kfad060-B11","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1016\/j.cell.2015.02.014","article-title":"The RNA binding protein quaking regulates formation of circRNAs","volume":"160","author":"Conn","year":"2015","journal-title":"Cell"},{"key":"2023082912302472500_kfad060-B12","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.envint.2018.11.056","article-title":"Co-exposure to metals and polycyclic aromatic hydrocarbons, microRNA expression, and early health damage in coke oven workers","volume":"122","author":"Deng","year":"2019","journal-title":"Environ. Int"},{"key":"2023082912302472500_kfad060-B13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.canlet.2020.03.002","article-title":"Exosome-mediated transfer of circRNA CircNFIX enhances temozolomide resistance in glioma","volume":"479","author":"Ding","year":"2020","journal-title":"Cancer Lett"},{"key":"2023082912302472500_kfad060-B14","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.semcancer.2017.09.005","article-title":"Lung cancer epigenetics: from knowledge to applications","volume":"51","author":"Duruisseaux","year":"2018","journal-title":"Semin. Cancer Biol"},{"key":"2023082912302472500_kfad060-B15","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1158\/1055-9965.EPI-07-2518","article-title":"DNA methylation in tumor and matched normal tissues from non-small cell lung cancer patients","volume":"17","author":"Feng","year":"2008","journal-title":"Cancer Epidemiol. Biomarkers Prev"},{"key":"2023082912302472500_kfad060-B16","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/j.omtn.2019.09.032","article-title":"CircPUM1 promotes tumorigenesis and progression of ovarian cancer by sponging miR-615-5p and miR-6753-5p","volume":"18","author":"Guan","year":"2019","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"2023082912302472500_kfad060-B17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/jbt.22757","article-title":"Upregulated lnc-HZ02 and miR-HZ02 inhibited migration and invasion by downregulating the FAK\/SRC\/PI3K\/AKT pathway in BPDE-treated trophoblast cells","volume":"35","author":"Guo","year":"2021","journal-title":"J. Biochem. Mol. Toxicol"},{"key":"2023082912302472500_kfad060-B18","doi-asserted-by":"crossref","first-page":"e21789","DOI":"10.1096\/fj.202100376RR","article-title":"Novel lncRNA-HZ04 promotes BPDE-induced human trophoblast cell apoptosis and miscarriage by upregulating IP3 R1\/CaMKII\/SGCB pathway by competitively binding with miR-HZ04","volume":"35","author":"Huang","year":"2021","journal-title":"FASEB J"},{"key":"2023082912302472500_kfad060-B19","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1093\/toxsci\/kfr184","article-title":"Arsenic exposure and toxicology: a historical perspective","volume":"123","author":"Hughes","year":"2011","journal-title":"Toxicol. Sci"},{"key":"2023082912302472500_kfad060-B20","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/nature06885","article-title":"A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25","volume":"452","author":"Hung","year":"2008","journal-title":"Nature"},{"key":"2023082912302472500_kfad060-B21","first-page":"1","article-title":"Tobacco smoke and involuntary smoking","volume":"83","author":"IARC Working Group on the Evaluation of Carcinogenic Risks to Humans","year":"2004","journal-title":"IARC Monogr. Eval. Carcinog. Risks Hum"},{"key":"2023082912302472500_kfad060-B22","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.celrep.2014.12.019","article-title":"Analysis of intron sequences reveals hallmarks of circular RNA biogenesis in animals","volume":"10","author":"Ivanov","year":"2015","journal-title":"Cell Rep"},{"key":"2023082912302472500_kfad060-B23","first-page":"129","article-title":"Malignant transformation of human bronchial epithelial cells induced by benzo(a)pyrene metabolite dihydroxyepoxy benzo pyrene","volume":"30","author":"Jiang","year":"2001","journal-title":"Wei Sheng Yan Jiu"},{"key":"2023082912302472500_kfad060-B24","doi-asserted-by":"crossref","first-page":"699004","DOI":"10.3389\/fonc.2021.699004","article-title":"miR-377-3p-mediated EGR1 downregulation promotes b[a]p-induced lung tumorigenesis by Wnt\/beta-catenin transduction","volume":"11","author":"Ke","year":"2021","journal-title":"Front. Oncol"},{"key":"2023082912302472500_kfad060-B25","first-page":"3419","article-title":"p16(INK4a) and histology-specific methylation of CpG islands by exposure to tobacco smoke in non-small cell lung cancer","volume":"61","author":"Kim","year":"2001","journal-title":"Cancer Res"},{"key":"2023082912302472500_kfad060-B26","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1038\/s41571-021-00585-y","article-title":"The emerging roles of circRNAs in cancer and oncology","volume":"19","author":"Kristensen","year":"2022","journal-title":"Nat. Rev. Clin. Oncol"},{"key":"2023082912302472500_kfad060-B27","doi-asserted-by":"crossref","first-page":"W451","DOI":"10.1093\/nar\/gkl243","article-title":"RNAhybrid: microRNA target prediction easy, fast and flexible","volume":"34","author":"Kruger","year":"2006","journal-title":"Nucleic Acids Res"},{"key":"2023082912302472500_kfad060-B1598949","first-page":"277","article-title":"Circ_0000043 promotes the proliferation, migration, invasiveness, and epithelial-mesenchymal transition in breast cancer cells via the miR-136-Smad3 axis","volume":"99","author":"Leng","year":"2021","journal-title":"."},{"key":"2023082912302472500_kfad060-B28","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/s41467-020-20527-z","article-title":"circNDUFB2 inhibits non-small cell lung cancer progression via destabilizing IGF2BPs and activating anti-tumor immunity","volume":"12","author":"Li","year":"2021","journal-title":"Nat. Commun"},{"key":"2023082912302472500_kfad060-B29","doi-asserted-by":"crossref","first-page":"108825","DOI":"10.1016\/j.envres.2019.108825","article-title":"Circular RNAs as biomarkers and therapeutic targets in environmental chemical exposure-related diseases","volume":"180","author":"Li","year":"2020","journal-title":"Environ. Res"},{"key":"2023082912302472500_kfad060-B30","doi-asserted-by":"crossref","first-page":"2685","DOI":"10.1007\/s43032-022-00939-6","article-title":"Human trophoblast cell-derived extracellular vesicles facilitate preeclampsia by transmitting miR-1273d, miR-4492, and miR-4417 to target HLA-G","volume":"29","author":"Li","year":"2022","journal-title":"Reprod. Sci"},{"key":"2023082912302472500_kfad060-B31","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1080\/15384101.2021.1934625","article-title":"CircPUM1 promotes cell growth and glycolysis in NSCLC via up-regulating METTL3 expression through miR-590-5p","volume":"20","author":"Li","year":"2021","journal-title":"Cell Cycle"},{"key":"2023082912302472500_kfad060-B32","doi-asserted-by":"crossref","first-page":"9087","DOI":"10.1096\/fj.201802159RRR","article-title":"Activation of BDNF\/TrkB pathway promotes prostate cancer progression via induction of epithelial-mesenchymal transition and anoikis resistance","volume":"34","author":"Li","year":"2020","journal-title":"FASEB J"},{"key":"2023082912302472500_kfad060-B38719464","first-page":"141","article-title":"Knockdown of circPUM1 impedes cell growth, metastasis and glycolysis of papillary thyroid cancer via enhancing MAPK1 expression by serving as the sponge of miR-21-5p","volume":"43","author":"Li","year":"2021","journal-title":"."},{"key":"2023082912302472500_kfad060-B33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11882-020-00976-8","article-title":"The role of epigenetics in the chronic sinusitis with nasal polyp","volume":"21","author":"Liu","year":"2020","journal-title":"Curr. Allergy Asthma Rep"},{"key":"2023082912302472500_kfad060-B34","doi-asserted-by":"crossref","first-page":"876071","DOI":"10.3389\/fcell.2022.876071","article-title":"Multivariate logistic regression analysis of the correlation between five biomarkers and ovarian cancer in patients with intermediate-risk: a prospective cross-sectional study","volume":"10","author":"Liu","year":"2022","journal-title":"Front. Cell Dev. Biol"},{"key":"2023082912302472500_kfad060-B35","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/s12943-020-01203-8","article-title":"Circular RNA circCCDC9 acts as a miR-6792-3p sponge to suppress the progression of gastric cancer through regulating CAV1 expression","volume":"19","author":"Luo","year":"2020","journal-title":"Mol. Cancer"},{"key":"2023082912302472500_kfad060-B36","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/s12943-017-0663-2","article-title":"CircRNA: functions and properties of a novel potential biomarker for cancer","volume":"16","author":"Meng","year":"2017","journal-title":"Mol. Cancer"},{"key":"2023082912302472500_kfad060-B37","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/s41418-022-00948-7","article-title":"Specific expression and functions of circular RNAs","volume":"29","author":"Misir","year":"2022","journal-title":"Cell Death Differ"},{"key":"2023082912302472500_kfad060-B38","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1038\/s41592-022-01487-2","article-title":"Best practice standards for circular RNA research","volume":"19","author":"Nielsen","year":"2022","journal-title":"Nat. Methods"},{"key":"2023082912302472500_kfad060-B39","doi-asserted-by":"crossref","first-page":"1234850","DOI":"10.1126\/science.1234850","article-title":"Epithelial plasticity: a common theme in embryonic and cancer cells","volume":"342","author":"Nieto","year":"2013","journal-title":"Science"},{"key":"2023082912302472500_kfad060-B40","doi-asserted-by":"crossref","first-page":"102317","DOI":"10.1016\/j.redox.2022.102317","article-title":"Inhibition of STAT3-ferroptosis negative regulatory axis suppresses tumor growth and alleviates chemoresistance in gastric cancer","volume":"52","author":"Ouyang","year":"2022","journal-title":"Redox Biol"},{"key":"2023082912302472500_kfad060-B032863","first-page":"5281846","article-title":"Identification of novel circRNA-based ceRNA network involved in the pathogenesis of gastric cancer","volume":"2022","author":"Peng","year":"2022","journal-title":"."},{"key":"2023082912302472500_kfad060-B41","doi-asserted-by":"crossref","first-page":"106311","DOI":"10.1016\/j.phrs.2022.106311","article-title":"STAT3-EMT axis in tumors: modulation of cancer metastasis, stemness and therapy response","volume":"182","author":"Sadrkhanloo","year":"2022","journal-title":"Pharmacol. Res"},{"key":"2023082912302472500_kfad060-B42","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.chemosphere.2018.02.140","article-title":"Identification of circular RNAs and their alterations involved in developing male Xenopus laevis chronically exposed to atrazine","volume":"200","author":"Sai","year":"2018","journal-title":"Chemosphere"},{"key":"2023082912302472500_kfad060-B43","doi-asserted-by":"crossref","first-page":"e1003777","DOI":"10.1371\/journal.pgen.1003777","article-title":"Cell-type specific features of circular RNA expression","volume":"9","author":"Salzman","year":"2013","journal-title":"PLoS Genet"},{"key":"2023082912302472500_kfad060-B44","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.canlet.2018.03.049","article-title":"Circular RNA ciRS-7 accelerates ESCC progression through acting as a miR-876-5p sponge to enhance MAGE-A family expression","volume":"426","author":"Sang","year":"2018","journal-title":"Cancer Lett"},{"key":"2023082912302472500_kfad060-B45","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1093\/carcin\/bgl253","article-title":"The molecular epidemiology of lung cancer","volume":"28","author":"Schwartz","year":"2007","journal-title":"Carcinogenesis"},{"key":"2023082912302472500_kfad060-B46","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin"},{"key":"2023082912302472500_kfad060-B47","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.tiv.2017.10.003","article-title":"Manganese exposure: linking down-regulation of miRNA-7 and miRNA-433 with alpha-synuclein overexpression and risk of idiopathic Parkinson\u2019s disease","volume":"46","author":"Tarale","year":"2018","journal-title":"Toxicol. In Vitro"},{"key":"2023082912302472500_kfad060-B48","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1038\/nature06846","article-title":"A variant associated with nicotine dependence, lung cancer and peripheral arterial disease","volume":"452","author":"Thorgeirsson","year":"2008","journal-title":"Nature"},{"key":"2023082912302472500_kfad060-B49","first-page":"1068","article-title":"Environmental lead exposure: a public health problem of global dimensions","volume":"78","author":"Tong","year":"2000","journal-title":"Bull. World Health Organ"},{"key":"2023082912302472500_kfad060-B7938916","first-page":"243","article-title":"Quantitative analysis of DNA methylation profiles in lung cancer identifies aberrant DNA methylation of specific genes and its association with gender and cancer risk factors","volume":"69","author":"Vaissi\u00e8re","year":"2009","journal-title":"."},{"key":"2023082912302472500_kfad060-B50","doi-asserted-by":"crossref","first-page":"e90859","DOI":"10.1371\/journal.pone.0090859","article-title":"Circular RNA is expressed across the eukaryotic tree of life","volume":"9","author":"Wang","year":"2014","journal-title":"PLoS ONE"},{"key":"2023082912302472500_kfad060-B51","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s12943-021-01484-7","article-title":"Expanding uncapped translation and emerging function of circular RNA in carcinomas and noncarcinomas","volume":"21","author":"Wang","year":"2022","journal-title":"Mol. Cancer"},{"key":"2023082912302472500_kfad060-B52","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.canlet.2019.06.007","article-title":"hsa_circ_0091570 acts as a ceRNA to suppress hepatocellular cancer progression by sponging hsa-miR-1307","volume":"460","author":"Wang","year":"2019","journal-title":"Cancer Lett"},{"key":"2023082912302472500_kfad060-B172501142","first-page":"1075","article-title":"Circular RNA circ_0000043 promotes endometrial carcinoma progression by regulating miR-1271-5p\/CTNND1 axis","volume":"303","author":"Wei","year":"2021","journal-title":"."},{"key":"2023082912302472500_kfad060-B53","doi-asserted-by":"crossref","first-page":"115810","DOI":"10.1016\/j.envpol.2020.115810","article-title":"LncRNA H19-mediated M2 polarization of macrophages promotes myofibroblast differentiation in pulmonary fibrosis induced by arsenic exposure","volume":"268","author":"Xiao","year":"2021","journal-title":"Environ. Pollut"},{"key":"2023082912302472500_kfad060-B54","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s10565-021-09606-z","article-title":"Lnc-HZ08 regulates BPDE-induced trophoblast cell dysfunctions by promoting PI3K ubiquitin degradation and is associated with miscarriage","volume":"38","author":"Xie","year":"2022","journal-title":"Cell Biol. Toxicol"},{"key":"2023082912302472500_kfad060-B55","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1186\/s12943-022-01582-0","article-title":"The functional roles of the circRNA\/Wnt axis in cancer","volume":"21","author":"Xue","year":"2022","journal-title":"Mol. Cancer"},{"key":"2023082912302472500_kfad060-B56","doi-asserted-by":"crossref","first-page":"17462","DOI":"10.18632\/aging.203235","article-title":"miR-30a-5p suppresses lung squamous cell carcinoma via ATG5-mediated autophagy","volume":"13","author":"Yang","year":"2021","journal-title":"Aging"},{"key":"2023082912302472500_kfad060-B57","doi-asserted-by":"crossref","first-page":"3264","DOI":"10.1096\/fj.201701118R","article-title":"Silica-induced initiation of circular ZC3H4 RNA\/ZC3H4 pathway promotes the pulmonary macrophage activation","volume":"32","author":"Yang","year":"2018","journal-title":"FASEB J"},{"key":"2023082912302472500_kfad060-B58","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1038\/nrc3818","article-title":"Revisiting STAT3 signalling in cancer: new and unexpected biological functions","volume":"14","author":"Yu","year":"2014","journal-title":"Nat. Rev. Cancer"},{"key":"2023082912302472500_kfad060-B59","first-page":"1102","article-title":"Expression and regulatory role of ultraconserved long non-coding RNA uc.77 in lung cancer","volume":"44","author":"Yu","year":"2022","journal-title":"Zhonghua Zhong Liu Za Zhi"},{"key":"2023082912302472500_kfad060-B60","first-page":"1","article-title":"Silencing of circular RNA PUM1 inhibits clear cell renal cell carcinoma progression through the miR-340-5p\/FABP7 axis","volume":"42","author":"Zeng","year":"2021","journal-title":"J. Recept. Signal Transduct. Res"},{"key":"2023082912302472500_kfad060-B61","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/s12943-020-01221-6","article-title":"Circular RNA circSATB2 promotes progression of non-small cell lung cancer cells","volume":"19","author":"Zhang","year":"2020","journal-title":"Mol. Cancer"},{"key":"2023082912302472500_kfad060-B62","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1016\/j.ymthe.2017.06.009","article-title":"Characterization of circRNA-associated-ceRNA networks in a senescence-accelerated mouse prone 8 brain","volume":"25","author":"Zhang","year":"2017","journal-title":"Mol. Ther"},{"key":"2023082912302472500_kfad060-B63","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/j.molcel.2013.08.017","article-title":"Circular intronic long noncoding RNAs","volume":"51","author":"Zhang","year":"2013","journal-title":"Mol. Cell"},{"key":"2023082912302472500_kfad060-B5354988","first-page":"4127","article-title":"Circ_PUM1 promotes the development of endometrial cancer by targeting the miR-136\/NOTCH3 pathway","volume":"24","author":"Zong","year":"2020","journal-title":"."}],"container-title":["Toxicological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/toxsci\/advance-article-pdf\/doi\/10.1093\/toxsci\/kfad060\/50729661\/kfad060.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/toxsci\/article-pdf\/195\/1\/87\/51276756\/kfad060.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/toxsci\/article-pdf\/195\/1\/87\/51276756\/kfad060.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T12:42:45Z","timestamp":1693312965000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/toxsci\/article\/195\/1\/87\/7199618"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,16]]},"references-count":69,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,6,16]]},"published-print":{"date-parts":[[2023,8,29]]}},"URL":"https:\/\/doi.org\/10.1093\/toxsci\/kfad060","relation":{},"ISSN":["1096-6080","1096-0929"],"issn-type":[{"value":"1096-6080","type":"print"},{"value":"1096-0929","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,9,1]]},"published":{"date-parts":[[2023,6,16]]}}}